Smart portable pen for continuous monitoring of anaesthetics in human serum with machine learning

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesiologist and patient with continuous drug monitoring. Direct detection of drugs is achieved with electrochemical techniques, and several options are present in literature to measure propofol (widely used anaesthetics). Still, the sensors proposed do not enable in-situ detection, they do not provide this information continuously, and they are based on bulky and costly lab equipment. In this paper, we present a novel smart pen-shaped electronic system for continuous monitoring of propofol in human serum. The system consists of a needle-shaped sensor, a quasi digital front-end, a smart machine learning data processing, in a single wireless battery-operated embedded device featuring Bluetooth Low Energy (BLE) communication. The system has been tested and characterized in real, undiluted human serum, at 37°C. The device features a limit of detection of 3.8µM, meeting the requirement of the target application, with an electronics system 59% smaller and 81% less power consuming w.r.t. the state-of-the-art, using a smart machine learning classification for data processing, which guarantees up to twenty continuous measure

Active C4 electrodes for local field potential recording applications

Extracellular neural recording, with multi-electrode arrays (MEAs), is a powerful method used to study neural function at the network level. However, in a high density array, it can be costly and time consuming to integrate the active circuit with the expensive electrodes. In this paper, we present a 4 mm × 4 mm neural recording integrated circuit (IC) chip, utilizing IBM C4 bumps as recording electrodes, which enable a seamless active chip and electrode integration. The IC chip was designed and fabricated in a 0.13 μm BiCMOS process for both in vitro and in vivo applications. It has an input-referred noise of 4.6 μV rms for the bandwidth of 10 Hz to 10 kHz and a power dissipation of 11.25 mW at 2.5 V, or 43.9 μW per input channel. This prototype is scalable for implementing larger number and higher density electrode arrays. To validate the functionality of the chip, electrical testing results and acute in vivo recordings from a rat barrel cortex are presented.R01 NS072385 - NINDS NIH HHS; 1R01 NS072385 - NINDS NIH HH

An ultra-low-power area-efficient non-coherent binary phase-shift keying demodulator for implantable biomedical microsystems

A novel non-coherent, low-power, area-efficient binary phase-shift keying demodulator for wireless implantable biomedical microsystems is proposed. The received data and synchronized clock signal are detected using a delayed digitized format of the input signal. The proposed technique does not require any kind of oscillator circuit, and due to the synchronization of all circuit signals, the proposed demodulator can work in a wide range of biomedical data telemetry common frequencies in different process/temperature corners. The presented circuit has been designed and post-layout-simulated in a standard 0.18 µm CMOS technology and occupies 17 × 27 µm2 of active area. Post-layout simulation results indicate that with a 1.8 V power supply, power consumption of the designed circuit is 8.5 µW at a data rate of 20 Mbps. The presented demodulation scheme was also implemented on a proof-of-concept circuit board for verifying its functionality

Future of smart cardiovascular implants

Cardiovascular disease remains the leading cause of death in Western society. Recent technological advances have opened the opportunity of developing new and innovative smart stent devices that have advanced electrical properties that can improve diagnosis and even treatment of previously intractable conditions, such as central line access failure, atherosclerosis and reporting on vascular grafts for renal dialysis. Here we review the latest advances in the field of cardiovascular medical implants, providing a broad overview of the application of their use in the context of cardiovascular disease rather than an in-depth analysis of the current state of the art. We cover their powering, communication and the challenges faced in their fabrication. We focus specifically on those devices required to maintain vascular access such as ones used to treat arterial disease, a major source of heart attacks and strokes. We look forward to advances in these technologies in the future and their implementation to improve the human condition

Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review article, we report and discuss the three most relevant methodologies for extremely miniaturised implantable neurostimulator: ultrasound coupling, inductive coupling and capacitive coupling. For each powering method, the discussion starts describing the physical working principle. In particular, we focus on the challenges given by the miniaturisation of the implanted integrated circuits and the related ad-hoc solutions for wireless power transfer. Then, we present recent developments and progresses in wireless power transfer for biomedical applications. Last, we compare each technique based on key performance indicators to highlight the most relevant and innovative solutions suitable for neurostimulation, with the gaze turned towards miniaturisation

Recent Advances in Microwave Imaging for Breast Cancer Detection

Breast cancer is a disease that occurs most often in female cancer patients. Early detection can significantly reduce the mortality rate. Microwave breast imaging, which is noninvasive and harmless to human, offers a promising alternative method to mammography. This paper presents a review of recent advances in microwave imaging for breast cancer detection. We conclude by introducing new research on a microwave imaging system with time-domain measurement that achieves short measurement time and low system cost. In the time-domain measurement system, scan time would take less than 1 sec, and it does not require very expensive equipment such as VNA

Person identification using deep neural networks on physiological biomarkers during exercise

Much progress has been made in wearable sensors that provide real-time continuous physiological data from non- invasive measurements including heart rate and biofluids such as sweat. This information can potentially be used to identify the health condition of a person by applying machine learning algorithms on the physiological measurements. We present a person identification task that uses machine learning algorithms on a set of biomarkers collected from 30 subjects carrying out a cycling experiment. We compared an SVM and a gated recurrent neural network (RNN) for real-time accuracy using different window sizes of the measured data. Results show that using all biomarkers gave the best results from any of the models. With all biomarkers, the gated RNN model achieved ∼90% accuracy even in a 30 s time window; and ∼92.3% accuracy in a 150 s time window. Excluding any of the biomarkers leads to at least 7.4% absolute accuracy drop for the RNN model. The RNN implementation on the Jetson Nano incurs a low latency of ∼45 ms per inference

Electrochemical Instrumentation of an Embedded Potentiostat System (EPS) for a Programmable-System-On-a-Chip

Under the main features required on portable devices in electrochemical instrumentation is to have a small size, low power consumption, economically affordable and precision in the measurements. This paper describes the development of a programmable Embedded Potentiostat System (EPS) capable of performing electrochemical sensing over system-on-a-chip platforms. Furthermore, the study explains a circuit design and develops some validation of the entire system. The hardware validation is performed by electrochemical experiments such as Double Step Chronoamperometry (DSC), Linear Sweep Voltammetry (LSV) and Cyclic Voltammetry (CV); moreover, a comparison of the experimental signals between a commercial potentiostat and the EPS was done by analysis of errors on the response signal. Results illustrate that the EPS is capable of handling currents in the range of absolute values of 86.44 to 3000 nA and having control voltages in the range of ± 2 V. The device can support from 50 to 2000 samples per second. The EPS capabilities were compared with other compact potentiostats. The programmable EPS is an original approach which hugely reduces the hardware complexity and leads the way to create new applications for Point-of-Care or industrial developments with a reusable full electronics module

HEAL-WEAR: an Ultra-Low Power Heterogeneous System for Bio-Signal Analysis

Personalized healthcare devices enable low-cost, unobtrusive and long-term acquisition of clinically-relevant biosignals. These appliances, termed Wireless Body Sensor Nodes (WBSNs), are fostering a revolution in health monitoring for patients affected by chronic ailments. Nowadays, WBSNs often embed complex digital processing routines, which must be performed within an extremely tight energy budget. Addressing this challenge, in this paper we introduce a novel computing architecture devoted to the ultra-low power analysis of biosignals. Its heterogeneous structure comprises multiple processors interfaced with a shared acceleration resource, implemented as a Coarse Grained Reconfigurable Array (CGRA). The CGRA mesh effectively supports the execution of the intensive loops that characterize bio-signal analysis applications, while requiring a low reconfiguration overhead. Moreover, both the processors and the reconfigurable fabric feature Single-Instruction / Multiple- Data (SIMD) execution modes, which increase efficiency when multiple data streams are concurrently processed. The run-time behavior on the system is orchestrated by a light-weight hardware mechanism, which concurrently synchronizes processors for SIMD execution and regulates access to the reconfigurable accelerator. By jointly leveraging run-time reconfiguration and SIMD execution, the illustrated heterogeneous system achieves, when executing complex bio-signal analysis applications, speedups of up to 11.3x on the considered kernels and up to 37.2% overall energy savings, with respect to an ultra-low power multicore platform which does not feature CGRA acceleration