Color image quality measures and retrieval

The focus of this dissertation is mainly on color image, especially on the images with lossy compression. Issues related to color quantization, color correction, color image retrieval and color image quality evaluation are addressed. A no-reference color image quality index is proposed. A novel color correction method applied to low bit-rate JPEG image is developed. A novel method for content-based image retrieval based upon combined feature vectors of shape, texture, and color similarities has been suggested. In addition, an image specific color reduction method has been introduced, which allows a 24-bit JPEG image to be shown in the 8-bit color monitor with 256-color display. The reduction in download and decode time mainly comes from the smart encoder incorporating with the proposed color reduction method after color space conversion stage. To summarize, the methods that have been developed can be divided into two categories: one is visual representation, and the other is image quality measure. Three algorithms are designed for visual representation: (1) An image-based visual representation for color correction on low bit-rate JPEG images. Previous studies on color correction are mainly on color image calibration among devices. Little attention was paid to the compressed image whose color distortion is evident in low bit-rate JPEG images. In this dissertation, a lookup table algorithm is designed based on the loss of PSNR in different compression ratio. (2) A feature-based representation for content-based image retrieval. It is a concatenated vector of color, shape, and texture features from region of interest (ROI). (3) An image-specific 256 colors (8 bits) reproduction for color reduction from 16 millions colors (24 bits). By inserting the proposed color reduction method into a JPEG encoder, the image size could be further reduced and the transmission time is also reduced. This smart encoder enables its decoder using less time in decoding. Three algorithms are designed for image quality measure (IQM): (1) A referenced IQM based upon image representation in very low-dimension. Previous studies on IQMs are based on high-dimensional domain including spatial and frequency domains. In this dissertation, a low-dimensional domain IQM based on random projection is designed, with preservation of the IQM accuracy in high-dimensional domain. (2) A no-reference image blurring metric. Based on the edge gradient, the degree of image blur can be measured. (3) A no-reference color IQM based upon colorfulness, contrast and sharpness

Content Based Image Retrieval (CBIR) in Remote Clinical Diagnosis and Healthcare

Content-Based Image Retrieval (CBIR) locates, retrieves and displays images alike to one given as a query, using a set of features. It demands accessible data in medical archives and from medical equipment, to infer meaning after some processing. A problem similar in some sense to the target image can aid clinicians. CBIR complements text-based retrieval and improves evidence-based diagnosis, administration, teaching, and research in healthcare. It facilitates visual/automatic diagnosis and decision-making in real-time remote consultation/screening, store-and-forward tests, home care assistance and overall patient surveillance. Metrics help comparing visual data and improve diagnostic. Specially designed architectures can benefit from the application scenario. CBIR use calls for file storage standardization, querying procedures, efficient image transmission, realistic databases, global availability, access simplicity, and Internet-based structures. This chapter recommends important and complex aspects required to handle visual content in healthcare.Comment: 28 pages, 6 figures, Book Chapter from "Encyclopedia of E-Health and Telemedicine

Neural Network and Bioinformatic Methods for Predicting HIV-1 Protease Inhibitor Resistance

This article presents a new method for predicting viral resistance to seven protease inhibitors from the HIV-1 genotype, and for identifying the positions in the protease gene at which the specific nature of the mutation affects resistance. The neural network Analog ARTMAP predicts protease inhibitor resistance from viral genotypes. A feature selection method detects genetic positions that contribute to resistance both alone and through interactions with other positions. This method has identified positions 35, 37, 62, and 77, where traditional feature selection methods have not detected a contribution to resistance. At several positions in the protease gene, mutations confer differing degress of resistance, depending on the specific amino acid to which the sequence has mutated. To find these positions, an Amino Acid Space is introduced to represent genes in a vector space that captures the functional similarity between amino acid pairs. Feature selection identifies several new positions, including 36, 37, and 43, with amino acid-specific contributions to resistance. Analog ARTMAP networks applied to inputs that represent specific amino acids at these positions perform better than networks that use only mutation locations.Air Force Office of Scientific Research (F49620-01-1-0423); National Geospatial-Intelligence Agency (NMA 201-01-1-2016); National Science Foundation (SBE-0354378); Office of Naval Research (N00014-01-1-0624