31,009 research outputs found
Laser Based Mid-Infrared Spectroscopic Imaging – Exploring a Novel Method for Application in Cancer Diagnosis
A number of biomedical studies have shown that mid-infrared spectroscopic images can provide
both morphological and biochemical information that can be used for the diagnosis of cancer. Whilst
this technique has shown great potential it has yet to be employed by the medical profession. By
replacing the conventional broadband thermal source employed in modern FTIR spectrometers with
high-brightness, broadly tuneable laser based sources (QCLs and OPGs) we aim to solve one of the
main obstacles to the transfer of this technology to the medical arena; namely poor signal to noise
ratios at high spatial resolutions and short image acquisition times. In this thesis we take the first
steps towards developing the optimum experimental configuration, the data processing algorithms
and the spectroscopic image contrast and enhancement methods needed to utilise these high
intensity laser based sources. We show that a QCL system is better suited to providing numerical
absorbance values (biochemical information) than an OPG system primarily due to the QCL pulse
stability. We also discuss practical protocols for the application of spectroscopic imaging to cancer
diagnosis and present our spectroscopic imaging results from our laser based spectroscopic imaging
experiments of oesophageal cancer tissue
The Photodetector Array Camera and Spectrometer (PACS) on the Herschel Space Observatory
The Photodetector Array Camera and Spectrometer (PACS) is one of the three
science instruments on ESA's far infrared and submillimetre observatory. It
employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16x25
pixels, each, and two filled silicon bolometer arrays with 16x32 and 32x64
pixels, respectively, to perform integral-field spectroscopy and imaging
photometry in the 60-210\mu\ m wavelength regime. In photometry mode, it
simultaneously images two bands, 60-85\mu\ m or 85-125\mu\m and 125-210\mu\ m,
over a field of view of ~1.75'x3.5', with close to Nyquist beam sampling in
each band. In spectroscopy mode, it images a field of 47"x47", resolved into
5x5 pixels, with an instantaneous spectral coverage of ~1500km/s and a spectral
resolution of ~175km/s. We summarise the design of the instrument, describe
observing modes, calibration, and data analysis methods, and present our
current assessment of the in-orbit performance of the instrument based on the
Performance Verification tests. PACS is fully operational, and the achieved
performance is close to or better than the pre-launch predictions
Quantum-inspired computational imaging
Computational imaging combines measurement and computational methods with the aim of forming images even when the measurement conditions are weak, few in number, or highly indirect. The recent surge in quantum-inspired imaging sensors, together with a new wave of algorithms allowing on-chip, scalable and robust data processing, has induced an increase of activity with notable results in the domain of low-light flux imaging and sensing. We provide an overview of the major challenges encountered in low-illumination (e.g., ultrafast) imaging and how these problems have recently been addressed for imaging applications in extreme conditions. These methods provide examples of the future imaging solutions to be developed, for which the best results are expected to arise from an efficient codesign of the sensors and data analysis tools.Y.A. acknowledges support from the UK Royal Academy of Engineering under the Research Fellowship Scheme (RF201617/16/31). S.McL. acknowledges financial support from the UK Engineering and Physical Sciences Research Council (grant EP/J015180/1). V.G. acknowledges support from the U.S. Defense Advanced Research Projects Agency (DARPA) InPho program through U.S. Army Research Office award W911NF-10-1-0404, the U.S. DARPA REVEAL program through contract HR0011-16-C-0030, and U.S. National Science Foundation through grants 1161413 and 1422034. A.H. acknowledges support from U.S. Army Research Office award W911NF-15-1-0479, U.S. Department of the Air Force grant FA8650-15-D-1845, and U.S. Department of Energy National Nuclear Security Administration grant DE-NA0002534. D.F. acknowledges financial support from the UK Engineering and Physical Sciences Research Council (grants EP/M006514/1 and EP/M01326X/1). (RF201617/16/31 - UK Royal Academy of Engineering; EP/J015180/1 - UK Engineering and Physical Sciences Research Council; EP/M006514/1 - UK Engineering and Physical Sciences Research Council; EP/M01326X/1 - UK Engineering and Physical Sciences Research Council; W911NF-10-1-0404 - U.S. Defense Advanced Research Projects Agency (DARPA) InPho program through U.S. Army Research Office; HR0011-16-C-0030 - U.S. DARPA REVEAL program; 1161413 - U.S. National Science Foundation; 1422034 - U.S. National Science Foundation; W911NF-15-1-0479 - U.S. Army Research Office; FA8650-15-D-1845 - U.S. Department of the Air Force; DE-NA0002534 - U.S. Department of Energy National Nuclear Security Administration)Accepted manuscrip
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