9,846 research outputs found
Cross-interval histogram analysis of neuronal activity on multi-electrode arrays
Cross-neuron-interval histogram (CNIH) analysis has been performed in order to study correlated activity and connectivity between pairs of neurons in a spontaneously active developing cultured network of rat cortical cells. Thirty-eight histograms could be analyzed using two parameters, one for the shape and one for the average number per interval bin. The histogram shape varied gradually between flat and clearly peaked around zero interval, indicating no/abundant connectivity and direct connection pathways, respectively
Automatic Crack Detection in Built Infrastructure Using Unmanned Aerial Vehicles
This paper addresses the problem of crack detection which is essential for
health monitoring of built infrastructure. Our approach includes two stages,
data collection using unmanned aerial vehicles (UAVs) and crack detection using
histogram analysis. For the data collection, a 3D model of the structure is
first created by using laser scanners. Based on the model, geometric properties
are extracted to generate way points necessary for navigating the UAV to take
images of the structure. Then, our next step is to stick together those
obtained images from the overlapped field of view. The resulting image is then
clustered by histogram analysis and peak detection. Potential cracks are
finally identified by using locally adaptive thresholds. The whole process is
automatically carried out so that the inspection time is significantly improved
while safety hazards can be minimised. A prototypical system has been developed
for evaluation and experimental results are included.Comment: In proceeding of The 34th International Symposium on Automation and
Robotics in Construction (ISARC), pp. 823-829, Taipei, Taiwan, 201
Optic Disk Segmentation Using Histogram Analysis
In the field of disease diagnosis with ophthalmic aids, automatic segmentation of the retinal optic disc is required. The main challenge in OD segmentation is to determine the exact location of the OD and remove noise in the retinal image. This paper proposes a method for automatic optical disc segmentation on color retinal fundus images using histogram analysis. Based on the properties of the optical disk, where the optical disk tends to occupy a high intensity. This method has been applied to the Digital Retinal Database for Vessel Extraction (DRIVE)and MESSIDOR database. The experimental results show that the proposed automatic optical segmentation method has an accuracy of 55% for DRIVE dataset and 89% for MESSIDOR databas
Histogram analysis as a method for determining the line tension by Monte-Carlo simulations
A method is proposed for determining the line tension, which is the main
physical characteristic of a three-phase contact region, by Monte-Carlo (MC)
simulations. The key idea of the proposed method is that if a three-phase
equilibrium involves a three-phase contact region, the probability distribution
of states of a system as a function of two order parameters depends not only on
the surface tension, but also on the line tension. This probability
distribution can be obtained as a normalized histogram by appropriate MC
simulations, so one can use the combination of histogram analysis and
finite-size scaling to study the properties of a three phase contact region.
Every histogram and results extracted therefrom will depend on the size of the
simulated system. Carrying out MC simulations for a series of system sizes and
extrapolating the results, obtained from the corresponding series of
histograms, to infinite size, one can determine the line tension of the three
phase contact region and the interfacial tensions of all three interfaces (and
hence the contact angles) in an infinite system. To illustrate the proposed
method, it is applied to the three-dimensional ternary fluid mixture, in which
molecular pairs of like species do not interact whereas those of unlike species
interact as hard spheres. The simulated results are in agreement with
expectations
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Diffusion MR Characteristics Following Concurrent Radiochemotherapy Predicts Progression-Free and Overall Survival in Newly Diagnosed Glioblastoma.
The standard of care for newly diagnosed glioblastoma (GBM) is surgery, then radiotherapy (RT) with concurrent temozolomide (TMZ), followed by adjuvant TMZ. We hypothesized patients with low diffusivity measured using apparent diffusion coefficient (ADC) histogram analysis evaluated after RT+TMZ, prior to adjuvant TMZ, would have a significantly shorter progression-free (PFS) and overall survival (OS). To test this hypothesis we evaluated 120 patients with newly diagnosed GBM receiving RT+TMZ followed by adjuvant TMZ. MRI was performed after completion of RT+TMZ, prior to initiation of adjuvant TMZ. A double Gaussian mixed model was used to describe the ADC histograms within the enhancing tumor, where ADCL and ADCH were defined as the mean ADC value of the lower and higher Gaussian distribution, respectively. An ADCL value of 1.0 um2/ms and ADCH value of 1.6 um2/ms were used to stratify patients into high and low risk categories. Results suggest patients with low ADCL had significantly shorter PFS (Cox Hazard Ratio = 0.12, P = 0.0006). OS was significantly shorter with low ADCL tumors, showing a median OS of 407 vs. 644 days (Cox Hazard Ratio = 0.31, P = 0.047). ADCH was not predictive of PFS or OS when accounting for age and ADCL. In summary, newly diagnosed glioblastoma patients with low ADCL after completion of RT+TMZ are likely to progress and die earlier than patients with higher ADCL. Results suggest ADC histogram analysis may be useful for patient risk stratification following completion of RT+TMZ
Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury.
Mild traumatic brain injury (mTBI) has become an increasing public health concern as subsequent injuries can exacerbate existing neuropathology and result in neurological deficits. This study investigated the temporal development of cortical lesions using magnetic resonance imaging (MRI) to assess two mTBIs delivered to opposite cortical hemispheres. The controlled cortical impact model was used to produce an initial mTBI on the right cortex followed by a second injury induced on the left cortex at 3 (rmTBI 3d) or 7 (rmTBI 7d) days later. Histogram analysis was combined with a novel semi-automated computational approach to perform a voxel-wise examination of extravascular blood and edema volumes within the lesion. Examination of lesion volume 1d post last injury revealed increased tissue abnormalities within rmTBI 7d animals compared to other groups, particularly at the site of the second impact. Histogram analysis of lesion T2 values suggested increased edematous tissue within the rmTBI 3d group and elevated blood deposition in the rm TBI 7d animals. Further quantification of lesion composition for blood and edema containing voxels supported our histogram findings, with increased edema at the site of second impact in rmTBI 3d animals and elevated blood deposition in the rmTBI 7d group at the site of the first injury. Histological measurements revealed spatial overlap of regions containing blood deposition and microglial activation within the cortices of all animals. In conclusion, our findings suggest that there is a window of tissue vulnerability where a second distant mTBI, induced 7d after an initial injury, exacerbates tissue abnormalities consistent with hemorrhagic progression
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