Identification of Topological Features in Renal Tumor Microenvironment Associated with Patient Survival

Motivation As a highly heterogeneous disease, the progression of tumor is not only achieved by unlimited growth of the tumor cells, but also supported, stimulated, and nurtured by the microenvironment around it. However, traditional qualitative and/or semi-quantitative parameters obtained by pathologist’s visual examination have very limited capability to capture this interaction between tumor and its microenvironment. With the advent of digital pathology, computerized image analysis may provide a better tumor characterization and give new insights into this problem. Results We propose a novel bioimage informatics pipeline for automatically characterizing the topological organization of different cell patterns in the tumor microenvironment. We apply this pipeline to the only publicly available large histopathology image dataset for a cohort of 190 patients with papillary renal cell carcinoma obtained from The Cancer Genome Atlas project. Experimental results show that the proposed topological features can successfully stratify early- and middle-stage patients with distinct survival, and show superior performance to traditional clinical features and cellular morphological and intensity features. The proposed features not only provide new insights into the topological organizations of cancers, but also can be integrated with genomic data in future studies to develop new integrative biomarkers

Integrative Analysis of Histopathological Images and Genomic Data Predicts Clear Cell Renal Cell Carcinoma Prognosis

In cancer, both histopathologic images and genomic signatures are used for diagnosis, prognosis, and subtyping. However, combining histopathologic images with genomic data for predicting prognosis, as well as the relationships between them, has rarely been explored. In this study, we present an integrative genomics framework for constructing a prognostic model for clear cell renal cell carcinoma. We used patient data from The Cancer Genome Atlas (n = 410), extracting hundreds of cellular morphologic features from digitized whole-slide images and eigengenes from functional genomics data to predict patient outcome. The risk index generated by our model correlated strongly with survival, outperforming predictions based on considering morphologic features or eigengenes separately. The predicted risk index also effectively stratified patients in early-stage (stage I and stage II) tumors, whereas no significant survival difference was observed using staging alone. The prognostic value of our model was independent of other known clinical and molecular prognostic factors for patients with clear cell renal cell carcinoma. Overall, this workflow and the shared software code provide building blocks for applying similar approaches in other cancers

Big data for treatment planning: pathways and possibilities for smart healthcare systems

Background: Treatment planning is one of the crucial stages of healthcare assessment and delivery. Moreover, it also has a significant impact on patient outcomes and system efficiency. With the evolution of transformative healthcare technologies, most areas of healthcare have started collecting data at different levels, as a result of which there is a splurge in the size and complexity of health data being generated every minute. Introduction: This paper explores the different characteristics of health data with respect to big data. Besides this, it also classifies research efforts in treatment planning on the basis of the informatics domain being used, which includes medical informatics, imaging informatics and translational bioinformatics. Methods: This is a survey paper that reviews existing literature on the use of big data technologies for treatment planning in the healthcare ecosystem. Therefore, a qualitative research methodology was adopted for this work. Results: Review of existing literature has been analyzed to identify potential gaps in research, identifying and providing insights into high prospect areas for potential future research. Conclusion: The use of big data for treatment planning is rapidly evolving, and findings of this research can head start and streamline specific research pathways in the field

Accurate and budget-efficient text, image, and video analysis systems powered by the crowd

Crowdsourcing systems empower individuals and companies to outsource labor-intensive tasks that cannot currently be solved by automated methods and are expensive to tackle by domain experts. Crowdsourcing platforms are traditionally used to provide training labels for supervised machine learning algorithms. Crowdsourced tasks are distributed among internet workers who typically have a range of skills and knowledge, differing previous exposure to the task at hand, and biases that may influence their work. This inhomogeneity of the workforce makes the design of accurate and efficient crowdsourcing systems challenging. This dissertation presents solutions to improve existing crowdsourcing systems in terms of accuracy and efficiency. It explores crowdsourcing tasks in two application areas, political discourse and annotation of biomedical and everyday images. The first part of the dissertation investigates how workers' behavioral factors and their unfamiliarity with data can be leveraged by crowdsourcing systems to control quality. Through studies that involve familiar and unfamiliar image content, the thesis demonstrates the benefit of explicitly accounting for a worker's familiarity with the data when designing annotation systems powered by the crowd. The thesis next presents Crowd-O-Meter, a system that automatically predicts the vulnerability of crowd workers to believe \enquote{fake news} in text and video. The second part of the dissertation explores the reversed relationship between machine learning and crowdsourcing by incorporating machine learning techniques for quality control of crowdsourced end products. In particular, it investigates if machine learning can be used to improve the quality of crowdsourced results and also consider budget constraints. The thesis proposes an image analysis system called ICORD that utilizes behavioral cues of the crowd worker, augmented by automated evaluation of image features, to infer the quality of a worker-drawn outline of a cell in a microscope image dynamically. ICORD determines the need to seek additional annotations from other workers in a budget-efficient manner. Next, the thesis proposes a budget-efficient machine learning system that uses fewer workers to analyze easy-to-label data and more workers for data that require extra scrutiny. The system learns a mapping from data features to number of allocated crowd workers for two case studies, sentiment analysis of twitter messages and segmentation of biomedical images. Finally, the thesis uncovers the potential for design of hybrid crowd-algorithm methods by describing an interactive system for cell tracking in time-lapse microscopy videos, based on a prediction model that determines when automated cell tracking algorithms fail and human interaction is needed to ensure accurate tracking