Learning and comparing functional connectomes across subjects

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven experiments they represent integration mechanisms between specialized brain areas. Analyzing their variability across subjects and conditions can reveal markers of brain pathologies and mechanisms underlying cognition. Methods of estimating functional connectomes from the imaging signal have undergone rapid developments and the literature is full of diverse strategies for comparing them. This review aims to clarify links across functional-connectivity methods as well as to expose different steps to perform a group study of functional connectomes

Modeling Covariate Effects in Group Independent Component Analysis with Applications to Functional Magnetic Resonance Imaging

Independent component analysis (ICA) is a powerful computational tool for separating independent source signals from their linear mixtures. ICA has been widely applied in neuroimaging studies to identify and characterize underlying brain functional networks. An important goal in such studies is to assess the effects of subjects' clinical and demographic covariates on the spatial distributions of the functional networks. Currently, covariate effects are not incorporated in existing group ICA decomposition methods. Hence, they can only be evaluated through ad-hoc approaches which may not be accurate in many cases. In this paper, we propose a hierarchical covariate ICA model that provides a formal statistical framework for estimating and testing covariate effects in ICA decomposition. A maximum likelihood method is proposed for estimating the covariate ICA model. We develop two expectation-maximization (EM) algorithms to obtain maximum likelihood estimates. The first is an exact EM algorithm, which has analytically tractable E-step and M-step. Additionally, we propose a subspace-based approximate EM, which can significantly reduce computational time while still retain high model-fitting accuracy. Furthermore, to test covariate effects on the functional networks, we develop a voxel-wise approximate inference procedure which eliminates the needs of computationally expensive covariance estimation. The performance of the proposed methods is evaluated via simulation studies. The application is illustrated through an fMRI study of Zen meditation.Comment: 36 pages, 5 figure

Neural Connectivity with Hidden Gaussian Graphical State-Model

The noninvasive procedures for neural connectivity are under questioning. Theoretical models sustain that the electromagnetic field registered at external sensors is elicited by currents at neural space. Nevertheless, what we observe at the sensor space is a superposition of projected fields, from the whole gray-matter. This is the reason for a major pitfall of noninvasive Electrophysiology methods: distorted reconstruction of neural activity and its connectivity or leakage. It has been proven that current methods produce incorrect connectomes. Somewhat related to the incorrect connectivity modelling, they disregard either Systems Theory and Bayesian Information Theory. We introduce a new formalism that attains for it, Hidden Gaussian Graphical State-Model (HIGGS). A neural Gaussian Graphical Model (GGM) hidden by the observation equation of Magneto-encephalographic (MEEG) signals. HIGGS is equivalent to a frequency domain Linear State Space Model (LSSM) but with sparse connectivity prior. The mathematical contribution here is the theory for high-dimensional and frequency-domain HIGGS solvers. We demonstrate that HIGGS can attenuate the leakage effect in the most critical case: the distortion EEG signal due to head volume conduction heterogeneities. Its application in EEG is illustrated with retrieved connectivity patterns from human Steady State Visual Evoked Potentials (SSVEP). We provide for the first time confirmatory evidence for noninvasive procedures of neural connectivity: concurrent EEG and Electrocorticography (ECoG) recordings on monkey. Open source packages are freely available online, to reproduce the results presented in this paper and to analyze external MEEG databases