A framework for epidemic spreading in multiplex networks of metapopulations

We propose a theoretical framework for the study of epidemics in structured metapopulations, with heterogeneous agents, subjected to recurrent mobility patterns. We propose to represent the heterogeneity in the composition of the metapopulations as layers in a multiplex network, where nodes would correspond to geographical areas and layers account for the mobility patterns of agents of the same class. We analyze both the classical Susceptible-Infected-Susceptible and the Susceptible-Infected-Removed epidemic models within this framework, and compare macroscopic and microscopic indicators of the spreading process with extensive Monte Carlo simulations. Our results are in excellent agreement with the simulations. We also derive an exact expression of the epidemic threshold on this general framework revealing a non-trivial dependence on the mobility parameter. Finally, we use this new formalism to address the spread of diseases in real cities, specifically in the city of Medellin, Colombia, whose population is divided into six socio-economic classes, each one identified with a layer in this multiplex formalism.Comment: 13 pages, 11 figure

Exploring the Impact of Socio-Technical Core-Periphery Structures in Open Source Software Development

In this paper we apply the social network concept of core-periphery structure to the sociotechnical structure of a software development team. We propose a socio-technical pattern that can be used to locate emerging coordination problems in Open Source projects. With the help of our tool and method called TESNA, we demonstrate a method to monitor the socio-technical core-periphery movement in Open Source projects. We then study the impact of different core-periphery movements on Open Source projects. We conclude that a steady core-periphery shift towards the core is beneficial to the project, whereas shifts away from the core are clearly not good. Furthermore, oscillatory shifts towards and away from the core can be considered as an indication of the instability of the project. Such an analysis can provide developers with a good insight into the health of an Open Source project. Researchers can gain from the pattern theory, and from the method we use to study the core-periphery movements

Computational purification of individual tumor gene expression profiles leads to significant improvements in prognostic prediction.

Tumor heterogeneity is a limiting factor in cancer treatment and in the discovery of biomarkers to personalize it. We describe a computational purification tool, ISOpure, to directly address the effects of variable normal tissue contamination in clinical tumor specimens. ISOpure uses a set of tumor expression profiles and a panel of healthy tissue expression profiles to generate a purified cancer profile for each tumor sample and an estimate of the proportion of RNA originating from cancerous cells. Applying ISOpure before identifying gene signatures leads to significant improvements in the prediction of prognosis and other clinical variables in lung and prostate cancer

Analysis of close encounters with Ganymede and Callisto using a genetic n-body algorithm

In this work we describe a genetic algorithm which is used in order to study orbits of minor bodies in the frames of close encounters. We find that the algorithm in combination with standard orbital numerical integrators can be used as a good proxy for finding typical orbits of minor bodies in close encounters with planets and even their moons, saving a lot of computational time compared to long-term orbital numerical integrations. Here, we study close encounters of Centaurs with Callisto and Ganymede in particular. We also perform n-body numerical simulations for comparison. We find typical impact velocities to be between $v_{rel}=20[v_{esc}]$ and $v_{rel}=30[v_{esc}]$ for Ganymede and between $v_{rel}=25[v_{esc}]$ and $v_{rel}=35[v_{esc}]$ for Callisto.Comment: 18 pages, 3 figure

Desktop security as a three-dimensional problem

In this paper we argue against viewing computer desktop security solely as a technical issue. Instead, we propose a perspective that combines three related dimensions: technical infrastructure, usability and user engagement. In this light, we suggest that a viable approach to desktop security should embrace these three key dimensions of the end-user context. An example desktop application is described that has been engineered to embody these dimensions in support of the desktop user