Development of Dose Conversion Coefficients for Radionuclides Produced in Spallation Neutron Sources

A research consortium comprised of representatives from several universities and national laboratories will be established as part of this project to generate internal and external dose conversion coefficients for radionuclides produced in spallation neutron sources. Information obtained from this multi-year study will be used to support the siting and licensing of future accelerator-driven nuclear initiatives within the U.S. Department of Energy complex, including the Spallation Neutron Source (SNS) and Accelerator Production of Tritium (APT) projects. Determination of these coefficients will also fill data gaps for several hundred radionuclides that exist in Federal Guidance Report (FGR) No. 11 and in Publications 68 and 72 of the International Commission on Radiological Protection (ICRP). This proposal discusses the overall research collaboration in general and the University of Nevada, Las Vegas (UNLV) funded portion of the research to be implemented by Phillip Patton and Mark Rudin in particular

Measuring Airborne Alpha Radioactivity

This project develops alpha spectroscopy to measure the airborne concentrations of attached and unattached radon progeny. The system is designed and constructed to be used in homes, thus is portable, fast, and easy to use

Need for Cognition and Message Complexity in Motivating Fruit and Vegetable Intake Among Callers to the Cancer Information Service

This field experiment examined the impact of an individual\u27s need for cognition (NFC; the tendency to enjoy thinking deeply about issues), complex versus simple messages, and the interaction of NFC and message type on encouraging fruit and vegetable consumption. Callers to the Cancer Information Service of the National Cancer Institute (N = 517) were asked to participate in the experiment at the end of their call. Individual NFC was assessed, and participants were assigned randomly to receive a telephone message promoting fruit and vegetable consumption that was either complex and multifaceted or simple and straightforward. Similarly constructed brochures were mailed immediately following the call, and additional brochures were mailed 2 and 3 months later. Although NFC did not predict intake, complex messages were more effective than simple messages in motivating fruit and vegetable consumption 1 and 4 months later

Development of Dose Conversion Coefficients for Radionuclides Produced in Spallation Neutron Sources Quarterly Progress Report 4/01/05 – 6/30/05

The research consortium comprised of representatives from several universities and national laboratories has successfully generated internal and external dose conversion coefficients for twenty radionuclides produced in spallation neutron sources. These dose coefficients fill data gaps exist in Federal Guide Report No. 11 and in Publications 68 and 72 of the International Commission on Radiological Protection (ICRP), and two articles containing the data have been accepted for publication in the Journal of Health Physics. Currently, more nuclear data is needed for the rare radionuclides produced from a mercury target. While attempting to develop a workable plan to acquire this missing data, Q-value discrepancies are being investigated

Potential Reduction of Lung Dose via VMAT with Jaw Tracking in the Treatment of Single-Isocenter/Two-Lesion Lung SBRT

Purpose/objectives: Due to higher radiosensitivity, non‐target normal tissue dose is a major concern in stereotactic body radiation therapy (SBRT) treatment. The aim of this report was to estimate the dosimetric impact, specifically the reduction of normal lung dose in the treatment of single‐isocenter/two‐lesion lung SBRT via volumetric modulated arc therapy with jaw tracking (JT‐VMAT). Materials/methods: Twelve patients with two peripherally located early‐stage non‐small‐cell‐lung cancer (NSCLC) lung lesions underwent single‐isocenter highly conformal non‐coplanar JT‐VMAT SBRT treatment in our institution. The mean isocenter to tumors distance was 5.6 ± 1.9 (range 4.3–9.5) cm. The mean combined planning target volume (PTV) was 38.7 ± 22.7 (range 5.0–80.9) cc. A single isocenter was placed between the two lesions. Doses were 54 and 50 Gy in three and five fractions, respectively. Plans were optimized in Eclipse with AcurosXB algorithm utilizing jaw tracking options for the Truebeam with a 6 MV‐FFF beam and standard 120 leaf millennium multi‐leaf collimators. For comparison, the JT‐VMAT plans were retrospectively re‐computed utilizing identical beam geometry, objectives, and planning parameters, but without jaw tracking (no JT‐VMAT). Both plans were normalized to receive the same target coverage. The conformity and heterogeneity indices, intermediate‐dose spillage [D2cm, R50, Gradient Index (GI), Gradient Distance (GD)], organs at risks (OAR) doses including normal lung as well as modulation factor (MF) were compared for both plans. Results: For similar target coverage, GI, R50, GD, as well as the normal lung V5, V10, V20, mean lung dose (MLD), and maximum dose received by 1000 cc of lungs were statistically significant. Normal lung doses were reduced by 8%–11% with JT‐VMAT. Normal lung dose increased as a function of tumor distance from isocenter. For the other OAR, up to 1%–16% reduction of non‐target doses were observed with JT‐VMAT. The MF and beam‐on time were similar for both plans, however, MF increased as a function of tumors distance, consequently, delivering higher dose to normal lungs. Conclusion: Utilizing jaw tracking options during optimization for single‐isocenter/two‐lesion lung SBRT VMAT plans reduced doses to the normal lung and other OAR, reduced intermediate‐dose spillage and provided superior/similar target coverage. Application of jaw tracking did not affect delivery efficiency and provided excellent plan quality with similar MF and beam‐on time. Jaw tracking is recommended for future clinical SBRT plan optimization

Community Health Interventions to Reduce the Burden of Radon-Related Lung Cancer

Exposure to radon is the second leading cause of lung cancer in the United States. One in seven homes in Vermont has elevated levels of radon, but most patients are unaware of radon as a risk factor for lung cancer or that radon testing and mitigation services are available to them. To promote increased testing and mitigation of radon we screened patients presenting to a Family Medicine practice in Vermont about whether they had had these services done in their home. We also developed a patient education resource for providers to give to patients who had more questions about radon exposure, how to get it tested, and what can be done to reduce the radon levels within their homes.https://scholarworks.uvm.edu/fmclerk/1817/thumbnail.jp

Program “Miracle Grow”: Program Staff and Evaluators Joining Forces to Power-Up Program Potential

Like all living things, health education programs grow, change, and mature. If left unattended, however, they can fade, fail, or fall apart. Evaluation can strengthen a program, particularly when it is rooted in a strong relationship among experienced, knowledgeable, and motivated teams of planners, implementers, clients, and evaluators. Evaluation can be the key to helping your program realize its full potential and, even, if threatened, flourish. When program and evaluation staff work together on pilot/demonstration projects, new program roll-outs, or established interventions, the results are like “Miracle Grow” to your programs

Evaluation of Plan Quality and Treatment Efficiency for Single-Isocenter/Two-Lesion Lung Stereotactic Body Radiation Therapy

Purpose/objectives: To evaluate the plan quality and treatment delivery efficiency of single‐isocenter/two‐lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT). Materials/methods: Eight consecutive patients with two peripherally located early stage nonsmall‐cell‐lung cancer (NSCLC) lung lesions underwent single‐isocenter highly conformal noncoplanar VMAT SBRT treatment in our institution. A single‐isocenter was placed between the two lesions. Doses were 54 or 50 Gy in 3 and 5 fractions respectively. Patients were treated every other day. Plans were calculated in Eclipse with AcurosXB algorithm and normalized to at least 95% of the planning target volume (PTV) receiving 100% of the prescribed dose. For comparison, two‐isocenter plans (isocenter placed centrally in each target) were retrospectively created. Conformity indices (CIs), heterogeneity index (HI), gradient index (GI), gradient distance (GD), and D2cm were calculated. The normal lung V5, V10, V20, mean lung dose (MLD) and other organs at risk (OARs) doses were evaluated. Total number of monitor units (MUs), beam‐on time, and patient‐specific quality assurance (QA) results were recorded. Results: The mean isocenter to tumor distance was 6.7 ± 2.3 cm. The mean combined PTV was 44.0 ± 23.4 cc. There was no clinically significant difference in CI, HI, GD, GI, D2cm, and V20 including most of the OARs between single‐isocenter and two‐isocenter lung SBRT plans, evaluated per RTOG guidelines. However, for single‐isocenter plans as the distance between the lesions increased, the V5, V10, and MLD increased, marginally. The total number of MUs and beam‐on time was reduced by a factor of 1.5 for a single‐isocenter plan compared to a two‐isocenter plan. The single‐isocenter/two‐lesions VMAT lung SBRT QA plans demonstrated an accurate dose delivery of 98.1 ± 3.2% for clinical gamma passing rate of 3%/3 mm. Conclusion: The SBRT treatment of two peripherally located lung lesions with a centrally placed single‐isocenter was dosimetrically equivalent to two‐isocenter plans. Faster treatment delivery for single‐isocenter treatment can improve patient compliance and reduce the amount of intrafraction motion errors for well‐suited patients

Costing of actions to safeguard vulnerable Mexican households with young children from the consequences of COVID-19 social distancing measures

COVID-19 has imposed unprecedented challenges to society. As the pandemic evolves, the social distancing measures that have been globally enforced, while essential, are having undesirable socioeconomic side effects particularly among vulnerable populations. In Mexico, families who depend upon informal employment face increased threats to their wellbeing, and households who in addition have young children may face long-term consequences. The Mexican government has not yet taken actions, but a coalition of non-governmental organizations is advocating in partnership with academic institutions for social protection actions such as a cash transfer and basic services subsidies for families with young children, subsisting from the informal sector economy. To facilitate governmental action, we estimated the costs for implementation of these recommendations. The methodology used could be replicated in other countries facing similar challenges

Estimation Of Entrance Skin Dose And Effective Dose In Cervical Spine X-Ray Procedures

The use of ionizing radiation in medical field is the largest and a growing man-made source of radiation exposure. The aim of this study is to estimate the doses received by patients during radiological examinations in order to standardize the examination procedures and optimize the patient dose. Two most referral hospitals, located in the Capital City of Kebbi State, were investigated. The Patients undergoing cervical spine X-ray examinations were involved in this study.  Entrance Skin Dose (ESD) and Effective Dose were calculated using exposure parameters (voltage, tube loading, focus-patient distance). The Cal Dose _X 5.0 software was used to determine ESD and ED. Conversion coefficients were used to relate ESD to the effective dose (ED). A total of 65 radiographic examinations data were collected from the two hospitals during three months of the year 2021 to 2022. The highest ESD (mGy) was found for the lateral cervical view in Sir Yahaya Memorial Hospital, with an average value of 4.12 mGy. The highest value of ED and DRLs was also observed for the AP projection in FMC with an average of 0.27 mSv and 4.73. The ESDs reported in this study are generally higher than value obtained from the research conducted by the Iran, and Brazil, while ED was remarkably high compared to other studies. This trend is an indication that the patient radiation protection practices in these two hospitals need to be justified. The results of this study showed that there is a need for justification and optimization in order to reduce patient radiation dose without affecting the quality of the radiographic image. The data of this work will be useful in contributing to the formulation of regional guidance levels