“Desirous of Improvements in Medicine : Pupils and Practitioners in the Medical Societies at Guy\u27s and St. Bartholomews Hospitals, 1795–1815

Guy\u27s Hospital Physical Society and St. Bartholomew\u27s Hospital Medical and Philosophical Society served important educational and professional functions in London between 1795 and 1815. They provided the opportunity for discussing everyday problems, sharing new discoveries and encouraging pupils to exploit fully their hospital experiences. They allowed hospital men to pontificate at times, but also to support the efforts of local practitioners and ambitious students. While not improving medicine in the sense of directing research or organizing clinical investigations, they did help medical men at all levels to think about their experiences before their observations were lost in the demands of the next case. Perhaps most important, the societies fostered the medical communities associated with three of the great London hospitals. They did this by providing links between pupils and practitioners from different hospitals, different kinds of practice, and different professional levels

“Desirous of Improvements in Medicine : Pupils and Practitioners in the Medical Societies at Guy\u27s and St. Bartholomews Hospitals, 1795–1815

Guy\u27s Hospital Physical Society and St. Bartholomew\u27s Hospital Medical and Philosophical Society served important educational and professional functions in London between 1795 and 1815. They provided the opportunity for discussing everyday problems, sharing new discoveries and encouraging pupils to exploit fully their hospital experiences. They allowed hospital men to pontificate at times, but also to support the efforts of local practitioners and ambitious students. While not improving medicine in the sense of directing research or organizing clinical investigations, they did help medical men at all levels to think about their experiences before their observations were lost in the demands of the next case. Perhaps most important, the societies fostered the medical communities associated with three of the great London hospitals. They did this by providing links between pupils and practitioners from different hospitals, different kinds of practice, and different professional levels

Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi-center, open-label, 52-week phase 3 trial

Intravenous immunoglobulin (IVIg) therapy is currently the only established treatment in patients with multifocal motor neuropathy (MMN), and many patients have an IVIg‐dependent fluctuation. We aimed to investigate the efficacy and safety of every 3 week IVIg (1.0 g/kg) for 52 weeks. This study was an open‐label phase 3 clinical trial, enrolling 13 MMN patients. After an induction IVIg therapy (0.4 g/kg/d for 5 consecutive days), maintenance dose (1.0 g/kg) was given every 3 weeks for 52 weeks. The major outcome measures were the Medical Research Council (MRC) sum score and hand‐grip strength at week 52. This trial is registered with ClinicalTrials.gov, number NCT01827072. At week 52, 11 of the 13 patients completed the study, and all 11 had a sustained improvement. The mean (SD) MRC sum score was 85.6 (8.7) at the baseline, and 90.6 (12.8) at week 52. The mean grip strength was 39.2 (30.0) kPa at the baseline and 45.2 (32.8) kPa at week 52. Two patients dropped out because of adverse event (dysphagia) and decision of an investigator, respectively. Three patients developed coronary spasm, dysphagia, or inguinal herniation, reported as the serious adverse events, but considered not related with the study drug. The other adverse effects were mild and resolved by the end of the study period. Our results show that maintenance treatment with 1.0 g/kg IVIg every 3 week is safe and efficacious for MMN patients up to 52 weeks. Further studies are required to investigate optimal dose and duration of maintenance IVIg for MMN

Barnes Hospital Record

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