Intrauterine repair of gastroschisis in fetal rabbits

Objective: Infants with gastroschisis (GS) still face severe morbidity. Prenatal closure may prevent gastrointestinal organ damage, but intrauterine GS repair (GSR) has not been established yet. Methods: In New Zealand White rabbits we developed and compared GS versus GSR: creation of GS was achieved by hysterotomy, right-sided laparotomy of the fetus and pressure on the abdominal wall to provoke evisceration. GSR was accomplished by careful reposition of eviscerated organs and a running suture of the fetal abdominal wall. For study purposes, 18 animals were divided equally into 3 groups: GS, GS with GSR after 2 h, and unmanipulated controls (C). Vitality was assessed by echocardiography. After 5 h all animals were sacrificed. Results: GSR inflicted no increased mortality, because all fetuses survived GS or GS with GSR. All fetuses with GS demonstrated significant evisceration of abdominal organs. In contrast, the abdominal wall of the fetuses from GSR was intact. Conclusion:The present animal model demonstrated the technical feasibility and success of an intrauterine repair of GS for the first time. However, further long-term studies (leaving GS and GSR in utero for several days) will be necessary to compare survival rates and intestinal injury, motility or absorption. The clinical application of GSR in utero remains a vision so far. Copyright (C) 2003 S. Karger AG, Basel

How Useful Is The Genuine Savings Rate As A Macroeconomic Sustainability Indicator For Countries And Regions? Australia And Queensland Compared

This paper demonstrates how macroeconomic indicators of sustainable development can be applied to the Queensland economy. We derive a Genuine Savings Rate (GSR) for Queensland for the period 1989 to 1999, which is then compared with the World Bank estimate of Australia's GSR for the same period. Specifically, we examine how well a single "headline" indicator based on the World Bank's GSR performs as a measure of overall sustainability. In doing so, we review criticisms of the GSR and compare its potential policy directives with those emerging from the use of net state savings and then the GSR as part of a suite of indicators.

Measurement of Emotional Response by Similarity in Patterns of Galvanic Skin Reflex

There is no doubt that many people feel the peace of mind or the pleasures of senses in appreciating music. But the estimation of the effect is very difficult and the objective estimation can be hardly done. This study proposed the objective estimating method of human emotion utilizing galvanic skin reflex (GSR) which reflects a human psychological activity. In this method, not by individual response, but by the series of response and pattern of appearance of GSR, the emotional response under appreciating music was investigated. In the case of appreciation of the same classic music to several subjects, the individual GSR responses are random and remarkable characteristic could not be find on the results. However, on the patterns of appearance of GSR, the patterns obtaining from the same generation are much similar each other and the patterns obtaining from different generation are less similar. It was cleared that the same music gave different effect on different generations

Determination of Electrical Parameters for Skin during Galvanic Skin Reflex from Continuous Measurement

Skin impedance satisfies the Cole-Cole arc's law. The change of skin impedance during GSR (Galvanic Skin Reflex) can be expressed by the change of equivalent parallel resistance approximately. Using these characteristics, the complicated change of skin impedance during GSR can be determined continuously from the measurement value in one frequency point

An Exact Formula for the Average Run Length to False Alarm of the Generalized Shiryaev-Roberts Procedure for Change-Point Detection under Exponential Observations

We derive analytically an exact closed-form formula for the standard minimax Average Run Length (ARL) to false alarm delivered by the Generalized Shiryaev-Roberts (GSR) change-point detection procedure devised to detect a shift in the baseline mean of a sequence of independent exponentially distributed observations. Specifically, the formula is found through direct solution of the respective integral (renewal) equation, and is a general result in that the GSR procedure's headstart is not restricted to a bounded range, nor is there a "ceiling" value for the detection threshold. Apart from the theoretical significance (in change-point detection, exact closed-form performance formulae are typically either difficult or impossible to get, especially for the GSR procedure), the obtained formula is also useful to a practitioner: in cases of practical interest, the formula is a function linear in both the detection threshold and the headstart, and, therefore, the ARL to false alarm of the GSR procedure can be easily computed.Comment: 9 pages; Accepted for publication in Proceedings of the 12-th German-Polish Workshop on Stochastic Models, Statistics and Their Application