Does counseling increase sustained benefit of HAART among prison inmates after release to the community?

The lack of sustained effectiveness of HAART after release to the community of HIV-infected inmates treated in prison was well demonstrated by Springer et al. in a recent article. This disappointing result occurred even though all of the patients scheduled for release were referred for transitional case management services to a community-based organization and were provided with a 2-week supply of medications, a medical appointment with an HIV care provider, emergency housing and food, and assistance with other identified unmet needs

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis?

Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis. Case Report: We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia. Based on bone marrow (BM) findings and on liver biopsy showing extramedullary hematopoiesis, an initial diagnosis of PMF was formulated. The patient refused stem cell transplantation from an HLA-identical sibling. Low-dose melphalan was given, without any improvement. Two years later, a BM evaluation showed Gaucher cells. Low glucocerebrosidase and high chitotriosidase levels were indicative for GD. Molecular analysis revealed N370S/complex I mutations. Enzyme replacement therapy with imiglucerase was commenced, resulting in clinical and hematological improvements. Due to an unexpected and persistent organomegaly, PMF combined with GD were suspected. JAK2V617F, JAK2 exon 12, MPL, calreticulin, and exon 9 mutations were negative, and BM examination showed no marrow fibrosis. PMF was excluded. Twenty years after starting treatment, the peripheral cell count and liver size were normal, whereas splenomegaly persisted. Conclusion: In order to avoid a misdiagnosis, a diagnostic algorithm for patients with hepatosplenomegaly combined with cytopenia is suggested

Highlights and Conclusions of the Chalonge 14th Paris Cosmology Colloquium 2010: `The Standard Model of the Universe: Theory and Observations'

The Chalonge 14th Paris Cosmology Colloquium was held on 22-24 July 2010 in Paris Observatory on the Standard Model of the Universe: News from WMAP7, BICEP, QUAD, SPT, AMI, ACT, Planck, QUIJOTE and Herschel; dark matter (DM) searches and galactic observations; related theory and simulations. %aiming synthesis, progress and clarification. P Biermann, D Boyanovsky, A Cooray, C Destri, H de Vega, G Gilmore, S Gottlober, E Komatsu, S McGaugh, A Lasenby, R Rebolo, P Salucci, N Sanchez and A Tikhonov present here their highlights of the Colloquium. Inflection points emerged: LambdaWDM (Warm DM) emerges impressively over LambdaCDM whose galactic scale problems are ever-increasing. Summary and conclusions by H. J. de Vega, M. C. Falvella and N. G. Sanchez stress among other points: (i) Primordial CMB gaussianity is confirmed. Inflation effective theory predicts a tensor to scalar ratio 0.05-0.04 at reach/border line of next CMB observations, early fast-roll inflation provides lowest multipoles depression. SZ amplitudes are smaller than expected: CMB and X-ray data agree but intracluster models need revision and relaxed/non-relaxed clusters distinction. (ii) cosmic ray positron excess is explained naturally by astrophysical processes, annihilating/decaying dark matter needs growing tailoring. (iii) Cored (non cusped) DM halos and warm (keV scale mass) DM are increasingly favored from theory and observations, naturally producing observed small scale structures, wimps turn strongly disfavoured. LambdaWDM 1 keV simulations well reproduce observations. Evidence that LambdaCDM does not work at small scales is staggering. P Biermann presents his live minutes of the Colloquium and concludes that a keV sterile neutrino is the most interesting DM candidate. Photos of the Colloquium are included.Comment: 58 pages, 20 figures. Three contributions added: G. Gilmore, S. Gottlober and E. Komats

Serum thyroid hormone antibodies are frequent in patients with polyglandular autoimmune syndrome type 3, particularly in those who require thyroxine treatment

Polyglandular autoimmune syndrome (PAS) type 3 consists of autoimmune thyroid disease (AITD) coexisting with ≥1 non-thyroidal autoimmune disease (NTAID) other than Addison’s disease and hypoparathyroidism. We evaluated the prevalence and repertoire of thyroid hormones antibodies (THAb) in PAS-3 patients. Using a radioimmunoprecipation technique, we measured THAb (T3IgM, T3IgG, T4IgM, and T4IgG) in 107 PAS-3 patients and 88 controls (patients with AITD without any NTAID). Based on the selective coexistence of AITD with one NTAID (chronic autoimmune gastritis, non-segmental vitiligo or celiac disease), patients were divided into group 1 (chronic autoimmune gastritis positive, n = 64), group 2 (non-segmental vitiligo positive, n = 24), and group 3 (celiac disease positive, n = 15). At least one of the four THAb was detected in 45 PAS-3 patients (42.1%) and 28 controls (31.8%, P = 0.14), with similar rates in the three PAS-3 groups. The rates of T3Ab, T4Ab, and T3 + T4Ab were similar in groups 1 and 2, while in group 3, T3Ab was undetected (P = 0.02). In PAS-3 patients, the rate of levothyroxine treatment was greater in THAb-positive patients compared to THAb-negative patients (76.7 vs. 56.1%, P = 0.03, RR = 1.4, 95% CI 1.03–1.81). Not unexpectedly, levothyroxine daily dose was significantly higher in group 1 and group 3, namely in patients with gastrointestinal disorders, compared to group 2 (1.9 ± 0.4 and 1.8 ± 0.3 vs. 1.5 ± 0.2 μg/kg body weight, P = 0.0005 and P = 0.004). Almost half of PAS-3 patients have THAb, whose repertoire is similar if chronic autoimmune gastritis or celiac disease is present. A prospective study would confirm whether THAb positivity predicts greater likelihood of requiring levothyroxine treatment

Determinants of fibrinogen in an Italian population suffering from claudication. Lower fibrinogen in the south compared to middle and north of Italy. The ADEP Group.

Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications. In patients suffering from peripheral vascular disease (PVD) fibrinogen has been shown to be an independent predictor of cardiovascular disease but its determinants have never been examined in this clinical setting. DESIGN AND METHODS: Fibrinogen levels were related to clinical and laboratory variables in 2,111 patients suffering from PVD. We also analyzed whether there was a regional distribution of risk factors. RESULTS: The median values of fibrinogen was 312 mg/dL. The clinical variables examined did not differentiate patients with elevated or normal fibrinogen levels. In particular, patients with ankle/arm pressure ratio < 0.8 did not show a higher prevalence of fibrinogen > 312 mg/dL. Conversely, white blood cell (WBC) count and serum cholesterol levels were significantly associated with high fibrinogen levels (p < 0.0001). Multiple logistic regression analysis demonstrated that areas of Italy were differently associated with high plasma fibrinogen levels (p < 0.03): subjects in the north and middle of Italy having significantly higher values of fibrinogen than subjects in the south of Italy (p < 0.01). A similar regional distribution was observed for WBC count and serum cholesterol levels. INTERPRETATION AND CONCLUSIONS: The regional distribution of risk factors raises the question as to whether the already reported large variability of cardiovascular events so in PVD may be attributed to a non homogeneous distribution of risk factors

Attachment relationships and internalization and externalization problems in a group of adolescents with pathological gambling disorder

Objective: The evidence accumulated in the relevant literature suggests that the presence and evolution of gambling could be correlated with the internalizing and externalizing problems and with the attachment style. This paper aims at exploring this perspective further. In particular, it analyses how such risk factors interact within the specific context of adolescent gambling disorder. Method: The sample comprises 91 adolescents, 61 male and 30 female, in the 17-22 age range (M = 17.77; SD = 0.98). A structural equation model was used to examine the relationship between the Youth Self-Report latent factors and pathological gambling, and the mode of attachment was assumed to act as a moderator. Results: Our results suggest that in the group characterized by a fearful attachment style there was a positive relationship between somatization and propensity to risk (p = 0.008), whereas in the dismissing attachment group there was a positive relationship between a greater tendency to delinquent behaviour and gambling risk (p = 0.042). Conclusions: The various insecure attachment stylespatterns may contribute in different ways to the development of oppositional-provocative behaviour and problems of conduct in adolescents

First lattice QCD estimate of the g_{D^* D pi} coupling

We present the results of the first lattice QCD study of the strong coupling g_{D^* D pi}. From our simulations in the quenched approximation, we obtain g_{D^* D pi} = 18.8 +/- 2.3^{+1.1}_{-2.0} and hat(g)_c = 0.67 +/- 0.08^{+0.04}_{-0.06}. Whereas previous theoretical studies gave different predictions, our result favours a large value for hat(g)_c. It agrees very well with the recent experimental value by CLEO. hat(g) varies very little with the heavy mass and we find in the infinite mass limit hat(g)_infinity = 0.69(18).Comment: 24 pages, 7 figures; references added, corrected typos, Comments added about the continuum limi