Design Methodology of Fuzzy Expert System for the Diagnosis and Control of Obesity

Both developed and developing nations of the world have overtime experienced enormous increase in food and other consumables production. This has led to a rise in calorie intake by people living in these nations of the world. As calorie intake increases in the human system, lack of early detection or control leads to obesity. The study of obesity is gaining utmost importance because of the major health issues associated with it. If an obese prone patient is detected early enough, then quite a number of diseases can be prevented. The ability of fuzzy logic to reason with uncertain and imprecise data in addressing the specific problem of diagnosis and monitoring of diseases in our society cannot be over emphasized. In this paper we design methodology of fuzzy expert system to diagnose and monitor obesity in persons at early stage. The study will help reduce to a great minimum the fast rise of obesity in our society and the world at large. The proposed study is validated with MatLab, and is used as a tracking system with accuracy and robustness. Keywords: Obesity, Fuzzy Inference System, Body Mass Index, Body fat, Waist circumference

Sick and depressed? The causal impact of a diabetes diagnosis on depression.

Background: There is sparse evidence on the impact of health information on mental health as well as on the mechanisms governing this relationship. We estimate the causal impact of health information on mental health via the effect of a diabetes diagnosis on depression. Methods: We employ a fuzzy regression discontinuity design (RDD) exploiting the exogenous cut-off value of a biomarker used to diagnose type-2 diabetes (glycated haemoglobin, HbA1c) and information on psycometrically validated measures of diagnosed clinical depression drawn from rich administrative longitudinal individuallevel data from a large municipality in Spain. This approach allows estimating the causal impact of a type-2 diabetes diagnosis on clinical depression Results: We find that overall a type-2 diabetes diagnosis increases the probability of becoming depressed, however this effect appears to be driven mostly by women and particularly those who are relatively younger and obese. Results also appear to differ by changes in lifestyle induced by the diabetes diagnosis: while women who did not lose weight are more likely to develop depression, men who did lose weight present a reduced probability of being depressed. Results are robust to alternative parametric and non-parametric specifications and placebo tests. Conclusions: The study provides novel empirical evidence on the causal impact of health information on mental health, shedding light on gender-based differences in such effects and potential mechanisms through changes in lifestyle behaviours

Sick and depressed? The causal impact of a diabetes diagnosis on depression

Background There is sparse evidence on the impact of health information on mental health as well as on the mechanisms governing this relationship. We estimate the causal impact of health information on mental health via the effect of a diabetes diagnosis on depression. Methods We employ a fuzzy regression discontinuity design (RDD) exploiting the exogenous cut-off value of a biomarker used to diagnose type-2 diabetes (glycated haemoglobin, HbA1c) and information on psycometrically validated measures of diagnosed clinical depression drawn from rich administrative longitudinal individual-level data from a large municipality in Spain. This approach allows estimating the causal impact of a type-2 diabetes diagnosis on clinica ldepression. Results We find that overall a type-2 diabetes diagnosis increases the probability of becoming depressed, however this effect appears to be driven mostly by women, and in particular those who are relatively younger and obese. Results also appear to differ by changes in lifestyle induced by the diabetes diagnosis: while women who did not lose weight are more likely to develop depression, men who did lose weight present a reduced probability of being depressed. Results are robust to alternative parametric and non-parametric specifications and placebo tests. Conclusions The study provides novel empirical evidence on the causal impact of health information on mental health, shedding light on gender-based differences in such effects and potential mechanisms through changes in lifestyle behaviours.Spanish Ministry of Science, Innovation and Universities (grant number PID2019-105688RB-I00)The Tomás y Valiente Fellowship, Madrid Institute for Advanced Study (MIAS),Universidad Autónoma de Madrid (UAM),the Regional Government of Madrid (grant number H2019/HUM-5793)The Spanish Ministry of Science, Innovation and Universities (grant number PID2019-111765 GB-I00)

A Simple Modeling Framework For Prediction In The Human Glucose-Insulin System

In this paper, we build a new, simple, and interpretable mathematical model to describe the human glucose-insulin system. Our ultimate goal is the robust control of the blood glucose (BG) level of individuals to a desired healthy range, by means of adjusting the amount of nutrition and/or external insulin appropriately. By constructing a simple yet flexible model class, with interpretable parameters, this general model can be specialized to work in different settings, such as type 2 diabetes mellitus (T2DM) and intensive care unit (ICU); different choices of appropriate model functions describing uptake of nutrition and removal of glucose differentiate between the models. In both cases, the available data is sparse and collected in clinical settings, major factors that have constrained our model choice to the simple form adopted. The model has the form of a linear stochastic differential equation (SDE) to describe the evolution of the BG level. The model includes a term quantifying glucose removal from the bloodstream through the regulation system of the human body, and another two terms representing the effect of nutrition and externally delivered insulin. The parameters entering the equation must be learned in a patient-specific fashion, leading to personalized models. We present numerical results on patient-specific parameter estimation and future BG level forecasting in T2DM and ICU settings. The resulting model leads to the prediction of the BG level as an expected value accompanied by a band around this value which accounts for uncertainties in the prediction. Such predictions, then, have the potential for use as part of control systems which are robust to model imperfections and noisy data. Finally, a comparison of the predictive capability of the model with two different models specifically built for T2DM and ICU contexts is also performed.Comment: 47 pages, 9 figures, 7 table

Fuzzy Decision Tree-based Inference System for Liver Disease Diagnosis

Medical diagnosis can be challenging because of a number of factors. Uncertainty in the diagnosis process arises from inaccuracy in the measurement of patient attributes, missing attribute data and limitation in the medical expert’s ability to define cause and effect relationships when there are multiple interrelated variables. Given this situation, a decision support system, which can help doctors come up with a more reliable diagnosis, can have a lot of potential. Decision trees are used in data mining for classification and regression. They are simple to understand and interpret as they can be visualized. But, one of the disadvantages of decision tree algorithms is that they deal with only crisp or exact values for data. Fuzzy logic is described as logic that is used to describe and formalize fuzzy or inexact information and perform reasoning using such information. Although both decision trees and fuzzy rule-based systems have been used for medical diagnosis, there have been few attempts to use fuzzy decision trees in combination with fuzzy rules. This study explored the application of fuzzy logic to help diagnose liver diseases based on blood test results. In this project, inference systems aimed at classifying patient data using a fuzzy decision tree and a fuzzy rule-based system were designed and implemented. Fuzzy decision tree was used to generate rules that formed the rule-base for the diagnostic inference system. Results from this study indicate that for the specific patient data set used in this experiment, the fuzzy decision tree-based inferencing out performed both the crisp decision tree and the fuzzy rule-based inferencing in classification accuracy

pHealth 2021. Proc. of the 18th Internat. Conf. on Wearable Micro and Nano Technologies for Personalised Health, 8-10 November 2021, Genoa, Italy

Smart mobile systems – microsystems, smart textiles, smart implants, sensor-controlled medical devices – together with related body, local and wide-area networks up to cloud services, have become important enablers for telemedicine and the next generation of healthcare services. The multilateral benefits of pHealth technologies offer enormous potential for all stakeholder communities, not only in terms of improvements in medical quality and industrial competitiveness, but also for the management of healthcare costs and, last but not least, the improvement of patient experience. This book presents the proceedings of pHealth 2021, the 18th in a series of conferences on wearable micro and nano technologies for personalized health with personal health management systems, hosted by the University of Genoa, Italy, and held as an online event from 8 – 10 November 2021. The conference focused on digital health ecosystems in the transformation of healthcare towards personalized, participative, preventive, predictive precision medicine (5P medicine). The book contains 46 peer-reviewed papers (1 keynote, 5 invited papers, 33 full papers, and 7 poster papers). Subjects covered include the deployment of mobile technologies, micro-nano-bio smart systems, bio-data management and analytics, autonomous and intelligent systems, the Health Internet of Things (HIoT), as well as potential risks for security and privacy, and the motivation and empowerment of patients in care processes. Providing an overview of current advances in personalized health and health management, the book will be of interest to all those working in the field of healthcare today

Applications of Boolean modelling to study and stratify dynamics of a complex disease

Interpretation of omics data is needed to form meaningful hypotheses about disease mechanisms. Pathway databases give an overview of disease-related processes, while mathematical models give qualitative and quantitative insights into their complexity. Similarly to pathway databases, mathematical models are stored and shared on dedicated platforms. Moreover, community-driven initiatives such as disease maps encode disease-specific mechanisms in both computable and diagrammatic form using dedicated tools for diagram biocuration and visualisation. To investigate the dynamic properties of complex disease mechanisms, computationally readable content can be used as a scaffold for building dynamic models in an automated fashion. The dynamic properties of a disease are extremely complex. Therefore, more research is required to better understand the complexity of molecular mechanisms, which may advance personalized medicine in the future. In this study, Parkinson’s disease (PD) is analyzed as an example of a complex disorder. PD is associated with complex genetic, environmental causes and comorbidities that need to be analysed in a systematic way to better understand the progression of different disease subtypes. Studying PD as a multifactorial disease requires deconvoluting the multiple and overlapping changes to identify the driving neurodegenerative mechanisms. Integrated systems analysis and modelling can enable us to study different aspects of a disease such as progression, diagnosis, and response to therapeutics. Therefore, more research is required to better understand the complexity of molecular mechanisms, which may advance personalized medicine in the future. Modelling such complex processes depends on the scope and it may vary depending on the nature of the process (e.g. signalling vs metabolic). Experimental design and the resulting data also influence model structure and analysis. Boolean modelling is proposed to analyse the complexity of PD mechanisms. Boolean models (BMs) are qualitative rather than quantitative and do not require detailed kinetic information such as Petri nets or Ordinary Differential equations (ODEs). Boolean modelling represents a logical formalism where available variables have binary values of one (ON) or zero (OFF), making it a plausible approach in cases where quantitative details and kinetic parameters 9 are not available. Boolean modelling is well validated in clinical and translational medicine research. In this project, the PD map was translated into BMs in an automated fashion using different methods. Therefore, the complexity of disease pathways can be analysed by simulating the effect of genomic burden on omics data. In order to make sure that BMs accurately represent the biological system, validation was performed by simulating models at different scales of complexity. The behaviour of the models was compared with expected behavior based on validated biological knowledge. The TCA cycle was used as an example of a well-studied simple network. Different scales of complex signalling networks were used including the Wnt-PI3k/AKT pathway, and T-cell differentiation models. As a result, matched and mismatched behaviours were identified, allowing the models to be modified to better represent disease mechanisms. The BMs were stratified by integrating omics data from multiple disease cohorts. The miRNA datasets from the Parkinson’s Progression Markers Initiative study (PPMI) were analysed. PPMI provides an important resource for the investigation of potential biomarkers and therapeutic targets for PD. Such stratification allowed studying disease heterogeneity and specific responses to molecular perturbations. The results can support research hypotheses, diagnose a condition, and maximize the benefit of a treatment. Furthermore, the challenges and limitations associated with Boolean modelling in general were discussed, as well as those specific to the current study. Based on the results, there are different ways to improve Boolean modelling applications. Modellers can perform exploratory investigations, gathering the associated information about the model from literature and data resources. The missing details can be inferred by integrating omics data, which identifies missing components and optimises model accuracy. Accurate and computable models improve the efficiency of simulations and the resulting analysis of their controllability. In parallel, the maintenance of model repositories and the sharing of models in easily interoperable formats are also important