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Bond-Order Time Series Analysis for Detecting Reaction Events in Ab Initio Molecular Dynamics Simulations.
Ab initio molecular dynamics is able to predict novel reaction mechanisms by directly observing the individual reaction events that occur in simulation trajectories. In this article, we describe an approach for detecting reaction events from simulation trajectories using a physically motivated model based on time series analysis of ab initio bond orders. We found that applying a threshold to the bond order was insufficient for accurate detection, whereas peak finding on the first time derivative resulted in significantly improved accuracy. The model is trained on a reference set of reaction events representing the ideal result given unlimited computing resources. Our study includes two model systems: a heptanylium carbocation that undergoes hydride shifts and an unsaturated iron carbonyl cluster that features CO ligand migration and bridging behavior. The results indicate a high level of promise for this analysis approach to be used in mechanistic analysis of reactive AIMD simulations more generally
Sparse Modeling for Image and Vision Processing
In recent years, a large amount of multi-disciplinary research has been
conducted on sparse models and their applications. In statistics and machine
learning, the sparsity principle is used to perform model selection---that is,
automatically selecting a simple model among a large collection of them. In
signal processing, sparse coding consists of representing data with linear
combinations of a few dictionary elements. Subsequently, the corresponding
tools have been widely adopted by several scientific communities such as
neuroscience, bioinformatics, or computer vision. The goal of this monograph is
to offer a self-contained view of sparse modeling for visual recognition and
image processing. More specifically, we focus on applications where the
dictionary is learned and adapted to data, yielding a compact representation
that has been successful in various contexts.Comment: 205 pages, to appear in Foundations and Trends in Computer Graphics
and Visio
Self-Paced Learning: an Implicit Regularization Perspective
Self-paced learning (SPL) mimics the cognitive mechanism of humans and
animals that gradually learns from easy to hard samples. One key issue in SPL
is to obtain better weighting strategy that is determined by minimizer
function. Existing methods usually pursue this by artificially designing the
explicit form of SPL regularizer. In this paper, we focus on the minimizer
function, and study a group of new regularizer, named self-paced implicit
regularizer that is deduced from robust loss function. Based on the convex
conjugacy theory, the minimizer function for self-paced implicit regularizer
can be directly learned from the latent loss function, while the analytic form
of the regularizer can be even known. A general framework (named SPL-IR) for
SPL is developed accordingly. We demonstrate that the learning procedure of
SPL-IR is associated with latent robust loss functions, thus can provide some
theoretical inspirations for its working mechanism. We further analyze the
relation between SPL-IR and half-quadratic optimization. Finally, we implement
SPL-IR to both supervised and unsupervised tasks, and experimental results
corroborate our ideas and demonstrate the correctness and effectiveness of
implicit regularizers.Comment: 12 pages, 3 figure
Parametric Regression on the Grassmannian
We address the problem of fitting parametric curves on the Grassmann manifold
for the purpose of intrinsic parametric regression. As customary in the
literature, we start from the energy minimization formulation of linear
least-squares in Euclidean spaces and generalize this concept to general
nonflat Riemannian manifolds, following an optimal-control point of view. We
then specialize this idea to the Grassmann manifold and demonstrate that it
yields a simple, extensible and easy-to-implement solution to the parametric
regression problem. In fact, it allows us to extend the basic geodesic model to
(1) a time-warped variant and (2) cubic splines. We demonstrate the utility of
the proposed solution on different vision problems, such as shape regression as
a function of age, traffic-speed estimation and crowd-counting from
surveillance video clips. Most notably, these problems can be conveniently
solved within the same framework without any specifically-tailored steps along
the processing pipeline.Comment: 14 pages, 11 figure
Augmented Sparse Reconstruction of Protein Signaling Networks
The problem of reconstructing and identifying intracellular protein signaling
and biochemical networks is of critical importance in biology today. We sought
to develop a mathematical approach to this problem using, as a test case, one
of the most well-studied and clinically important signaling networks in biology
today, the epidermal growth factor receptor (EGFR) driven signaling cascade.
More specifically, we suggest a method, augmented sparse reconstruction, for
the identification of links among nodes of ordinary differential equation (ODE)
networks from a small set of trajectories with different initial conditions.
Our method builds a system of representation by using a collection of integrals
of all given trajectories and by attenuating block of terms in the
representation itself. The system of representation is then augmented with
random vectors, and minimization of the 1-norm is used to find sparse
representations for the dynamical interactions of each node. Augmentation by
random vectors is crucial, since sparsity alone is not able to handle the large
error-in-variables in the representation. Augmented sparse reconstruction
allows to consider potentially very large spaces of models and it is able to
detect with high accuracy the few relevant links among nodes, even when
moderate noise is added to the measured trajectories. After showing the
performance of our method on a model of the EGFR protein network, we sketch
briefly the potential future therapeutic applications of this approach.Comment: 24 pages, 6 figure
Why do ultrasoft repulsive particles cluster and crystallize? Analytical results from density functional theory
We demonstrate the accuracy of the hypernetted chain closure and of the
mean-field approximation for the calculation of the fluid-state properties of
systems interacting by means of bounded and positive-definite pair potentials
with oscillating Fourier transforms. Subsequently, we prove the validity of a
bilinear, random-phase density functional for arbitrary inhomogeneous phases of
the same systems. On the basis of this functional, we calculate analytically
the freezing parameters of the latter. We demonstrate explicitly that the
stable crystals feature a lattice constant that is independent of density and
whose value is dictated by the position of the negative minimum of the Fourier
transform of the pair potential. This property is equivalent with the existence
of clusters, whose population scales proportionally to the density. We
establish that regardless of the form of the interaction potential and of the
location on the freezing line, all cluster crystals have a universal Lindemann
ratio L = 0.189 at freezing. We further make an explicit link between the
aforementioned density functional and the harmonic theory of crystals. This
allows us to establish an equivalence between the emergence of clusters and the
existence of negative Fourier components of the interaction potential. Finally,
we make a connection between the class of models at hand and the system of
infinite-dimensional hard spheres, when the limits of interaction steepness and
space dimension are both taken to infinity in a particularly described fashion.Comment: 19 pages, 5 figures, submitted to J. Chem. Phys; new version: minor
changes in structure of pape
Socially Constrained Structural Learning for Groups Detection in Crowd
Modern crowd theories agree that collective behavior is the result of the
underlying interactions among small groups of individuals. In this work, we
propose a novel algorithm for detecting social groups in crowds by means of a
Correlation Clustering procedure on people trajectories. The affinity between
crowd members is learned through an online formulation of the Structural SVM
framework and a set of specifically designed features characterizing both their
physical and social identity, inspired by Proxemic theory, Granger causality,
DTW and Heat-maps. To adhere to sociological observations, we introduce a loss
function (G-MITRE) able to deal with the complexity of evaluating group
detection performances. We show our algorithm achieves state-of-the-art results
when relying on both ground truth trajectories and tracklets previously
extracted by available detector/tracker systems
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