Supporting UK-wide e-clinical trials and studies

As clinical trials and epidemiological studies become increasingly large, covering wider (national) geographical areas and involving ever broader populations, the need to provide an information management infrastructure that can support such endeavours is essential. A wealth of clinical data now exists at varying levels of care (primary care, secondary care, etc.). Simple, secure access to such data would greatly benefit the key processes involved in clinical trials and epidemiological studies: patient recruitment, data collection and study management. The Grid paradigm provides one model for seamless access to such data and support of these processes. The VOTES project (Virtual Organisations for Trials and Epidemiological Studies) is a collaboration between several UK institutions to implement a generic framework that effectively leverages the available health-care information across the UK to support more efficient gathering and processing of trial information. The structure of the information available in the health-care domain in the UK itself varies broadly in-line with the national boundaries of the constituent states (England, Scotland, Wales and Northern Ireland). Technologies must address these political boundaries and the impact these boundaries have in terms of for example, information governance, policies, and of course large-scale heterogeneous distribution of the data sets themselves. This paper outlines the methodology in implementing the framework between three specific data sources that serve as useful case studies: Scottish data from the Scottish Care Information (SCI) Store data repository, data on the General Practice Research Database (GPRD) diabetes trial at Imperial College London, and benign prostate hypoplasia (BPH) data from the University of Nottingham. The design, implementation and wider research issues are discussed along with the technological challenges encountered in the project in the application of Grid technologies

Grid infrastructures supporting paediatric endocrinology across Europe

Paediatric endocrinology is a highly specialised area of clinical medicine with many experts with specific knowledge distributed over a wide geographical area. The European Society for Paediatric Endocrinology (ESPE) is an example of such a body of experts that require regular collaboration and sharing of data and knowledge. This paper describes work, developed as a corollary to the VOTES project [1] and implementing similar architectures, to provide a data grid that allows information to be efficiently distributed between collaborating partners, and also allows wide-scale analyses to be run over the entire data-set, which necessarily involves crossing domain boundaries and negotiating data access between administrations that only trust each other to a limited degree

A flexible architecture for privacy-aware trust management

In service-oriented systems a constellation of services cooperate, sharing potentially sensitive information and responsibilities. Cooperation is only possible if the different participants trust each other. As trust may depend on many different factors, in a flexible framework for Trust Management (TM) trust must be computed by combining different types of information. In this paper we describe the TAS3 TM framework which integrates independent TM systems into a single trust decision point. The TM framework supports intricate combinations whilst still remaining easily extensible. It also provides a unified trust evaluation interface to the (authorization framework of the) services. We demonstrate the flexibility of the approach by integrating three distinct TM paradigms: reputation-based TM, credential-based TM, and Key Performance Indicator TM. Finally, we discuss privacy concerns in TM systems and the directions to be taken for the definition of a privacy-friendly TM architecture.\u

MICSIM : Concept, Developments and Applications of a PC-Microsimulation Model for Research and Teaching

It is the growing societal interest about the individual and its behaviour in our and 'modern' societies which is asking for microanalyses about the individual situation. In order to allow these microanalyses on a quantitative and empirically based level microsimulation models were developed and increasingly used for economic and social policy impact analyses. Though microsimulation is known and applied (mainly by experts), an easy to use and powerful PC microsimulation model is hard to find. The overall aim of this study and of MICSIM - A PC Microsimulation Model is to describe and offer such a user-friendly and powerful general microsimulation model for (almost) any PC, to support the impact microanalyses both in applied research and teaching. Above all, MICSIM is a general microdata handler for a wide range of typical microanalysis requirements. This paper presents the concept, developments and applications of MICSIM. After some brief remarks on microsimulation characteristics in general, the concept and substantive domains of MICSIM: the simulation, the adjustment and aging, and the evaluation of microdata, are described by its mode of operation in principle. The realisations and developments of MICSIM then are portrayed by the different versions of the computer program. Some MICSIM applications and experiences in research and teaching are following with concluding remarks.Economic and Social Policy Analyses, Microsimulation (dynamic and static), Simulation, Adjustment and Evaluation of Microdata, PC Computer Program for Microanalyses in General

Initial experiences in developing e-health solutions across Scotland

The MRC funded Virtual Organisations for Trials and Epidemiological Studies (VOTES) project is a collaborative effort between e-Science, clinical and ethical research centres across the UK including the universities of Oxford, Glasgow, Imperial, Nottingham and Leicester. The project started in September 2005 and is due to run for 3 years. The primary goal of VOTES is to develop a reusable Grid framework through which a multitude of clinical trials and epidemiological studies can be supported. The National e-Science Centre (NeSC) at the University of Glasgow are looking at developing the Scottish components of this framework. This paper presents the initial experiences in developing this framework and in accessing and using existing data sets, services and software across the NHS in Scotland

Hierarchical Role-Based Access Control with Homomorphic Encryption for Database as a Service

Database as a service provides services for accessing and managing customers data which provides ease of access, and the cost is less for these services. There is a possibility that the DBaaS service provider may not be trusted, and data may be stored on untrusted server. The access control mechanism can restrict users from unauthorized access, but in cloud environment access control policies are more flexible. However, an attacker can gather sensitive information for a malicious purpose by abusing the privileges as another user and so database security is compromised. The other problems associated with the DBaaS are to manage role hierarchy and secure session management for query transaction in the database. In this paper, a role-based access control for the multitenant database with role hierarchy is proposed. The query is granted with least access privileges, and a session key is used for session management. The proposed work protects data from privilege escalation and SQL injection. It uses the partial homomorphic encryption (Paillier Encryption) for the encrypting the sensitive data. If a query is to perform any operation on sensitive data, then extra permissions are required for accessing sensitive data. Data confidentiality and integrity are achieved using the role-based access control with partial homomorphic encryption.Comment: 11 Pages,4 figures, Proceedings of International Conference on ICT for Sustainable Developmen