17,748 research outputs found
Cooperative Synchronization in Wireless Networks
Synchronization is a key functionality in wireless network, enabling a wide
variety of services. We consider a Bayesian inference framework whereby network
nodes can achieve phase and skew synchronization in a fully distributed way. In
particular, under the assumption of Gaussian measurement noise, we derive two
message passing methods (belief propagation and mean field), analyze their
convergence behavior, and perform a qualitative and quantitative comparison
with a number of competing algorithms. We also show that both methods can be
applied in networks with and without master nodes. Our performance results are
complemented by, and compared with, the relevant Bayesian Cram\'er-Rao bounds
High Precision Measurements Using High Frequency Signals
Generalized lock-in amplifiers use digital cavities with Q-factors as high as
5X10^8. In this letter, we show that generalized lock-in amplifiers can be used
to analyze microwave (giga-hertz) signals with a precision of few tens of
hertz. We propose that the physical changes in the medium of propagation can be
measured precisely by the ultra-high precision measurement of the signal. We
provide evidence to our proposition by verifying the Newton's law of cooling by
measuring the effect of change in temperature on the phase and amplitude of the
signals propagating through two calibrated cables. The technique could be used
to precisely measure different physical properties of the propagation medium,
for example length, resistance, etc. Real time implementation of the technique
can open up new methodologies of in-situ virtual metrology in material design
Stochastic timing in gene expression for simple regulatory strategies
Timing is essential for many cellular processes, from cellular responses to
external stimuli to the cell cycle and circadian clocks. Many of these
processes are based on gene expression. For example, an activated gene may be
required to reach in a precise time a threshold level of expression that
triggers a specific downstream process. However, gene expression is subject to
stochastic fluctuations, naturally inducing an uncertainty in this
threshold-crossing time with potential consequences on biological functions and
phenotypes. Here, we consider such "timing fluctuations", and we ask how they
can be controlled. Our analytical estimates and simulations show that, for an
induced gene, timing variability is minimal if the threshold level of
expression is approximately half of the steady-state level. Timing fuctuations
can be reduced by increasing the transcription rate, while they are insensitive
to the translation rate. In presence of self-regulatory strategies, we show
that self-repression reduces timing noise for threshold levels that have to be
reached quickly, while selfactivation is optimal at long times. These results
lay a framework for understanding stochasticity of endogenous systems such as
the cell cycle, as well as for the design of synthetic trigger circuits.Comment: 10 pages, 5 figure
Noise control and utility: From regulatory network to spatial patterning
Stochasticity (or noise) at cellular and molecular levels has been observed
extensively as a universal feature for living systems. However, how living
systems deal with noise while performing desirable biological functions remains
a major mystery. Regulatory network configurations, such as their topology and
timescale, are shown to be critical in attenuating noise, and noise is also
found to facilitate cell fate decision. Here we review major recent findings on
noise attenuation through regulatory control, the benefit of noise via
noise-induced cellular plasticity during developmental patterning, and
summarize key principles underlying noise control
Limits on Fundamental Limits to Computation
An indispensable part of our lives, computing has also become essential to
industries and governments. Steady improvements in computer hardware have been
supported by periodic doubling of transistor densities in integrated circuits
over the last fifty years. Such Moore scaling now requires increasingly heroic
efforts, stimulating research in alternative hardware and stirring controversy.
To help evaluate emerging technologies and enrich our understanding of
integrated-circuit scaling, we review fundamental limits to computation: in
manufacturing, energy, physical space, design and verification effort, and
algorithms. To outline what is achievable in principle and in practice, we
recall how some limits were circumvented, compare loose and tight limits. We
also point out that engineering difficulties encountered by emerging
technologies may indicate yet-unknown limits.Comment: 15 pages, 4 figures, 1 tabl
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