7 research outputs found
MARGIN: Uncovering Deep Neural Networks using Graph Signal Analysis
Interpretability has emerged as a crucial aspect of machine learning, aimed
at providing insights into the working of complex neural networks. However,
existing solutions vary vastly based on the nature of the interpretability
task, with each use case requiring substantial time and effort. This paper
introduces MARGIN, a simple yet general approach to address a large set of
interpretability tasks ranging from identifying prototypes to explaining image
predictions. MARGIN exploits ideas rooted in graph signal analysis to determine
influential nodes in a graph, which are defined as those nodes that maximally
describe a function defined on the graph. By carefully defining task-specific
graphs and functions, we demonstrate that MARGIN outperforms existing
approaches in a number of disparate interpretability challenges.Comment: Technical Repor
Graph Signal Processing: Overview, Challenges and Applications
Research in Graph Signal Processing (GSP) aims to develop tools for
processing data defined on irregular graph domains. In this paper we first
provide an overview of core ideas in GSP and their connection to conventional
digital signal processing. We then summarize recent developments in developing
basic GSP tools, including methods for sampling, filtering or graph learning.
Next, we review progress in several application areas using GSP, including
processing and analysis of sensor network data, biological data, and
applications to image processing and machine learning. We finish by providing a
brief historical perspective to highlight how concepts recently developed in
GSP build on top of prior research in other areas.Comment: To appear, Proceedings of the IEE
Radiolabelled Molecules for Brain Imaging with PET and SPECT
Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are in vivo molecular imaging methods which are widely used in nuclear medicine for diagnosis and treatment follow-up of many major diseases. These methods use target-specific molecules as probes, which are labeled with radionuclides of short half-lives that are synthesized prior to the imaging studies. These probes are called radiopharmaceuticals. The use of PET and SPECT for brain imaging is of special significance since the brain controls all the body’s functions by processing information from the whole body and the outside world. It is the source of thoughts, intelligence, memory, speech, creativity, emotion, sensory functions, motion control, and other important body functions. Protected by the skull and the blood–brain barrier, the brain is somehow a privileged organ with regard to nutrient supply, immune response, and accessibility for diagnostic and therapeutic measures. Invasive procedures are rather limited for the latter purposes. Therefore, noninvasive imaging with PET and SPECT has gained high importance for a great variety of brain diseases, including neurodegenerative diseases, motor dysfunctions, stroke, epilepsy, psychiatric diseases, and brain tumors. This Special Issue focuses on radiolabeled molecules that are used for these purposes, with special emphasis on neurodegenerative diseases and brain tumors