Nonnegative Matrix Underapproximation for Robust Multiple Model Fitting

In this work, we introduce a highly efficient algorithm to address the nonnegative matrix underapproximation (NMU) problem, i.e., nonnegative matrix factorization (NMF) with an additional underapproximation constraint. NMU results are interesting as, compared to traditional NMF, they present additional sparsity and part-based behavior, explaining unique data features. To show these features in practice, we first present an application to the analysis of climate data. We then present an NMU-based algorithm to robustly fit multiple parametric models to a dataset. The proposed approach delivers state-of-the-art results for the estimation of multiple fundamental matrices and homographies, outperforming other alternatives in the literature and exemplifying the use of efficient NMU computations

Multichannel high resolution NMF for modelling convolutive mixtures of non-stationary signals in the time-frequency domain

Several probabilistic models involving latent components have been proposed for modeling time-frequency (TF) representations of audio signals such as spectrograms, notably in the nonnegative matrix factorization (NMF) literature. Among them, the recent high-resolution NMF (HR-NMF) model is able to take both phases and local correlations in each frequency band into account, and its potential has been illustrated in applications such as source separation and audio inpainting. In this paper, HR-NMF is extended to multichannel signals and to convolutive mixtures. The new model can represent a variety of stationary and non-stationary signals, including autoregressive moving average (ARMA) processes and mixtures of damped sinusoids. A fast variational expectation-maximization (EM) algorithm is proposed to estimate the enhanced model. This algorithm is applied to piano signals, and proves capable of accurately modeling reverberation, restoring missing observations, and separating pure tones with close frequencies

Multivariate Spatiotemporal Hawkes Processes and Network Reconstruction

There is often latent network structure in spatial and temporal data and the tools of network analysis can yield fascinating insights into such data. In this paper, we develop a nonparametric method for network reconstruction from spatiotemporal data sets using multivariate Hawkes processes. In contrast to prior work on network reconstruction with point-process models, which has often focused on exclusively temporal information, our approach uses both temporal and spatial information and does not assume a specific parametric form of network dynamics. This leads to an effective way of recovering an underlying network. We illustrate our approach using both synthetic networks and networks constructed from real-world data sets (a location-based social media network, a narrative of crime events, and violent gang crimes). Our results demonstrate that, in comparison to using only temporal data, our spatiotemporal approach yields improved network reconstruction, providing a basis for meaningful subsequent analysis --- such as community structure and motif analysis --- of the reconstructed networks

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues