46,751 research outputs found

    Merging expert and empirical data for rare event frequency estimation : pool homogenisation for empirical Bayes models

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    Empirical Bayes provides one approach to estimating the frequency of rare events as a weighted average of the frequencies of an event and a pool of events. The pool will draw upon, for example, events with similar precursors. The higher the degree of homogeneity of the pool, then the Empirical Bayes estimator will be more accurate. We propose and evaluate a new method using homogenisation factors under the assumption that events are generated from a Homogeneous Poisson Process. The homogenisation factors are scaling constants, which can be elicited through structured expert judgement and used to align the frequencies of different events, hence homogenising the pool. The estimation error relative to the homogeneity of the pool is examined theoretically indicating that reduced error is associated with larger pool homogeneity. The effects of misspecified expert assessments of the homogenisation factors are examined theoretically and through simulation experiments. Our results show that the proposed Empirical Bayes method using homogenisation factors is robust under different degrees of misspecification

    A Methodology for Variability Reduction in Manufacturing Cost Estimating in the Automotive Industry based on Design Features

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    Organised by: Cranfield UniversitySmall to medium manufacturing companies are coming to realise the increasing importance of performing fast and accurate cost estimates at the early stages of projects to address customers’ requests for quotation. However, they cannot afford the implementation of a knowledge-based cost estimating software. This paper explains the development and validation of a consistent methodology for the cost estimating of manufactured parts (focused on pistons) based on the design features. The research enabled the identification of the sources of variability in cost estimates, and the main one is the lack of formal procedures for the cost estimates in manufacturing SMEs. Finally, a software prototype was developed that reduces the variability in the cost estimates by defining a formal procedure, following the most appropriate cost estimating techniques.Mori Seiki – The Machine Tool Compan

    Mortality modelling and forecasting: a review of methods

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    Estimating past inhalation exposure to asbestos: a tool for risk attribution and disease screening

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    Introduction: Late presentation is common in mesothelioma. Reliable assessment of past exposure to asbestos is a necessary first step for risk attribution and for the development of a future screening programme. Such a programme could maximise access to trials of novel therapies and would pave the way for development of novel chemoprophylaxis strategies. This paper describes a method for individual exposure reconstruction along with data from a validation study. Methods: The exposure assessment method uses only descriptive information about the circumstances of the work that could be obtained from questioning the worker. The assessment is based on the tasks carried out and includes parameters for substance emission potential, activity emission potential, the effectiveness of any local control measures, passive emission, the fractional time the asbestos source is active and the efficiency of any respiratory protection worn. Results: There was a good association between the estimated and measured exposure levels. Pearson’s correlation coefficient between the log-transformed measurements and estimates from the model was 0.86, and 95% of the estimated individual values were within about a factor of ten of the associated measured value. The method described would be suitable for pre-selecting individuals at high risk of malignant pleural mesothelioma for screening using appropriate tools and/or enrolment in clinical trials of chemo-prophylaxis. Discussion: This method is of potential clinical value in developing novel treatment approaches for mesothelioma. Pilot studies to test this approach are urgently needed

    Estimating the cost of a new technology intensive automotive product: A case study approach.

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    Estimating cost of new technology intensive products is very ad hoc within the automotive industry. There is a need to develop a systematic approach to the cost estimating, which will make the estimates more realistic. This research proposes a methodology that uses parametric, analogy and detailed estimating techniques to enable a cost to be built for an automotive powertrain product with a high content of new technology. The research defines a process for segregating new or emerging technologies from current technologies to enable the various costing techniques to be utilised. The cost drivers from an internal combustion engine's characteristics to facilitate a cost estimate for high- volume production are also presented. A process to enable a costing expert to either build an estimate for the new technology under analysis or use a comparator and then develop a variant for the new system is also discussed. Due to the open nature of the statement ‘new technology’, research is also conducted to provide a meaningful definition applicable to the automotive industry and this pro

    Quantified Risk and Uncertainty Analysis

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    The legal requirement in the UK for the duty holder of a chemical process plant to demonstrate that risk is as low as reasonably practicable (ALARP) means that quantified risk assessments (QRAs) must be accurate and robust and that identified risks are adequately mitigated. Bayesian belief networks(BBN) is an emerging technique which can be used to determine the likelihood of an event in support of the QRA process. It is a statistical method involving estimating the probability distribution for a given hypothesis. The most interesting features which distinguish this QRA technique from all the others are: • it can analyse complex systems of any given number of variables and their dependability within a single analysis; • it can analyse parameters over a range of probability values for any given set of conditions, providing a better understanding in terms of sensitivity analysis; • it engages expert judgement and learning from previous events to update the probability distribution, thus improving QRA accuracy; and • it is not just restricted to fault analysis and can be used to support plant operational decision making using a quantified approac

    Multivariate reliability modelling with empirical Bayes inference

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    Recent developments in technology permit detailed descriptions of system performance to be collected and stored. Consequently, more data are available about the occurrence, or non-occurrence, of events across a range of classes through time. Typically this implies that reliability analysis has more information about the exposure history of a system within different classes of events. For highly reliable systems, there may be relatively few failure events. Thus there is a need to develop statistical inference to support reliability estimation when there is a low ratio of failures relative to event classes. In this paper we show how Empirical Bayes methods can be used to estimate a multivariate reliability function for a system by modelling the vector of times to realise each failure root cause
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