Implementing quantum logic gates with GRAPE: principles and practicalities

We briefly describe the use of GRAPE pulses to implement quantum logic gates in NMR quantum computers, and discuss a range of simple extensions to the core technique. We then consider a range of difficulties which can arise in practical implementations of GRAPE sequences, reflecting non-idealities in the experimental systems used.Comment: 15 pages rspublic including 4 figures. This is the original manuscript preprint form which differs slightly from the final accepted version (Phil Trans Roy Soc A in press

The utility of knowledge in inductive learning

In this paper, we demonstrate how different forms of background knowledge can be integrated with an inductive method for generating constant-free Horn clause rules. Furthermore, we evaluate, both theoretically and empirically, the effect that these types of knowledge have on the cost of learning a rule and on the accuracy of a learned rule. Moreover, we demonstrate that a hybrid explanation-based and inductive learning method can advantageously use an approximate domain theory, even when this theory is incorrect and incomplete

ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervious system

Alternative polyadenylation (APA) has been implicated in a variety of developmental and disease processes. A particularly dramatic form of APA occurs in the developing nervous system of flies and mammals, whereby various developmental genes undergo coordinate 3' UTR extension. In Drosophila, the RNA-binding protein ELAV inhibits RNA processing at proximal polyadenylation sites, thereby fostering the formation of exceptionally long 3' UTRs. Here, we present evidence that paused Pol II promotes recruitment of ELAV to extended genes. Replacing promoters of extended genes with heterologous promoters blocks normal 3' extension in the nervous system, while extension-associated promoters can induce 3' extension in ectopic tissues expressing ELAV. Computational analyses suggest that promoter regions of extended genes tend to contain paused Pol II and associated cis-regulatory elements such as GAGA. ChIP-seq assays identify ELAV in the promoter regions of extended genes. Our study provides evidence for a regulatory link between promoter-proximal pausing and APA

Cross-dimensional Weighting for Aggregated Deep Convolutional Features

We propose a simple and straightforward way of creating powerful image representations via cross-dimensional weighting and aggregation of deep convolutional neural network layer outputs. We first present a generalized framework that encompasses a broad family of approaches and includes cross-dimensional pooling and weighting steps. We then propose specific non-parametric schemes for both spatial- and channel-wise weighting that boost the effect of highly active spatial responses and at the same time regulate burstiness effects. We experiment on different public datasets for image search and show that our approach outperforms the current state-of-the-art for approaches based on pre-trained networks. We also provide an easy-to-use, open source implementation that reproduces our results.Comment: Accepted for publications at the 4th Workshop on Web-scale Vision and Social Media (VSM), ECCV 201