6,560 research outputs found

    Anuário científico da Escola Superior de Tecnologia da Saúde de Lisboa - 2021

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    É com grande prazer que apresentamos a mais recente edição (a 11.ª) do Anuário Científico da Escola Superior de Tecnologia da Saúde de Lisboa. Como instituição de ensino superior, temos o compromisso de promover e incentivar a pesquisa científica em todas as áreas do conhecimento que contemplam a nossa missão. Esta publicação tem como objetivo divulgar toda a produção científica desenvolvida pelos Professores, Investigadores, Estudantes e Pessoal não Docente da ESTeSL durante 2021. Este Anuário é, assim, o reflexo do trabalho árduo e dedicado da nossa comunidade, que se empenhou na produção de conteúdo científico de elevada qualidade e partilhada com a Sociedade na forma de livros, capítulos de livros, artigos publicados em revistas nacionais e internacionais, resumos de comunicações orais e pósteres, bem como resultado dos trabalhos de 1º e 2º ciclo. Com isto, o conteúdo desta publicação abrange uma ampla variedade de tópicos, desde temas mais fundamentais até estudos de aplicação prática em contextos específicos de Saúde, refletindo desta forma a pluralidade e diversidade de áreas que definem, e tornam única, a ESTeSL. Acreditamos que a investigação e pesquisa científica é um eixo fundamental para o desenvolvimento da sociedade e é por isso que incentivamos os nossos estudantes a envolverem-se em atividades de pesquisa e prática baseada na evidência desde o início dos seus estudos na ESTeSL. Esta publicação é um exemplo do sucesso desses esforços, sendo a maior de sempre, o que faz com que estejamos muito orgulhosos em partilhar os resultados e descobertas dos nossos investigadores com a comunidade científica e o público em geral. Esperamos que este Anuário inspire e motive outros estudantes, profissionais de saúde, professores e outros colaboradores a continuarem a explorar novas ideias e contribuir para o avanço da ciência e da tecnologia no corpo de conhecimento próprio das áreas que compõe a ESTeSL. Agradecemos a todos os envolvidos na produção deste anuário e desejamos uma leitura inspiradora e agradável.info:eu-repo/semantics/publishedVersio

    Preferentialism and the conditionality of trade agreements. An application of the gravity model

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    Modern economic growth is driven by international trade, and the preferential trade agreement constitutes the primary fit-for-purpose mechanism of choice for establishing, facilitating, and governing its flows. However, too little attention has been afforded to the differences in content and conditionality associated with different trade agreements. This has led to an under-considered mischaracterisation of the design-flow relationship. Similarly, while the relationship between trade facilitation and trade is clear, the way trade facilitation affects other areas of economic activity, with respect to preferential trade agreements, has received considerably less attention. Particularly, in light of an increasingly globalised and interdependent trading system, the interplay between trade facilitation and foreign direct investment is of particular importance. Accordingly, this thesis explores the bilateral trade and investment effects of specific conditionality sets, as established within Preferential Trade Agreements (PTAs). Chapter one utilises recent content condition-indexes for depth, flexibility, and constraints on flexibility, established by Dür et al. (2014) and Baccini et al. (2015), within a gravity framework to estimate the average treatment effect of trade agreement characteristics across bilateral trade relationships in the Association of Southeast Asian Nations (ASEAN) from 1948-2015. This chapter finds that the composition of a given ASEAN trade agreement’s characteristic set has significantly determined the concomitant bilateral trade flows. Conditions determining the classification of a trade agreements depth are positively associated with an increase to bilateral trade; hereby representing the furthered removal of trade barriers and frictions as facilitated by deeper trade agreements. Flexibility conditions, and constraint on flexibility conditions, are also identified as significant determiners for a given trade agreement’s treatment effect of subsequent bilateral trade flows. Given the political nature of their inclusion (i.e., the appropriate address to short term domestic discontent) this influence is negative as regards trade flows. These results highlight the longer implementation and time frame requirements for trade impediments to be removed in a market with higher domestic uncertainty. Chapter two explores the incorporation of non-trade issue (NTI) conditions in PTAs. Such conditions are increasing both at the intensive and extensive margins. There is a concern from developing nations that this growth of NTI inclusions serves as a way for high-income (HI) nations to dictate the trade agenda, such that developing nations are subject to ‘principled protectionism’. There is evidence that NTI provisions are partly driven by protectionist motives but the effect on trade flows remains largely undiscussed. Utilising the Gravity Model for trade, I test Lechner’s (2016) comprehensive NTI dataset for 202 bilateral country pairs across a 32-year timeframe and find that, on average, NTIs are associated with an increase to bilateral trade. Primarily this boost can be associated with the market access that a PTA utilising NTIs facilitates. In addition, these results are aligned theoretically with the discussions on market harmonisation, shared values, and the erosion of artificial production advantages. Instead of inhibiting trade through burdensome cost, NTIs are acting to support a more stable production and trading environment, motivated by enhanced market access. Employing a novel classification to capture the power supremacy associated with shaping NTIs, this chapter highlights that the positive impact of NTIs is largely driven by the relationship between HI nations and middle-to-low-income (MTLI) counterparts. Chapter Three employs the gravity model, theoretically augmented for foreign direct investment (FDI), to estimate the effects of trade facilitation conditions utilising indexes established by Neufeld (2014) and the bilateral FDI data curated by UNCTAD (2014). The resultant dataset covers 104 countries, covering a period of 12 years (2001–2012), containing 23,640 observations. The results highlight the bilateral-FDI enhancing effects of trade facilitation conditions in the ASEAN context, aligning itself with the theoretical branch of FDI-PTA literature that has outlined how the ratification of a trade agreement results in increased and positive economic prospect between partners (Medvedev, 2012) resulting from the interrelation between trade and investment as set within an improving regulatory environment. The results align with the expectation that an enhanced trade facilitation landscape (one in which such formalities, procedures, information, and expectations around trade facilitation are conditioned for) is expected to incentivise and attract FDI

    Estudo da remodelagem reversa miocárdica através da análise proteómica do miocárdio e do líquido pericárdico

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    Valve replacement remains as the standard therapeutic option for aortic stenosis patients, aiming at abolishing pressure overload and triggering myocardial reverse remodeling. However, despite the instant hemodynamic benefit, not all patients show complete regression of myocardial hypertrophy, being at higher risk for adverse outcomes, such as heart failure. The current comprehension of the biological mechanisms underlying an incomplete reverse remodeling is far from complete. Furthermore, definitive prognostic tools and ancillary therapies to improve the outcome of the patients undergoing valve replacement are missing. To help abridge these gaps, a combined myocardial (phospho)proteomics and pericardial fluid proteomics approach was followed, taking advantage of human biopsies and pericardial fluid collected during surgery and whose origin anticipated a wealth of molecular information contained therein. From over 1800 and 750 proteins identified, respectively, in the myocardium and in the pericardial fluid of aortic stenosis patients, a total of 90 dysregulated proteins were detected. Gene annotation and pathway enrichment analyses, together with discriminant analysis, are compatible with a scenario of increased pro-hypertrophic gene expression and protein synthesis, defective ubiquitinproteasome system activity, proclivity to cell death (potentially fed by complement activity and other extrinsic factors, such as death receptor activators), acute-phase response, immune system activation and fibrosis. Specific validation of some targets through immunoblot techniques and correlation with clinical data pointed to complement C3 β chain, Muscle Ring Finger protein 1 (MuRF1) and the dual-specificity Tyr-phosphorylation regulated kinase 1A (DYRK1A) as potential markers of an incomplete response. In addition, kinase prediction from phosphoproteome data suggests that the modulation of casein kinase 2, the family of IκB kinases, glycogen synthase kinase 3 and DYRK1A may help improve the outcome of patients undergoing valve replacement. Particularly, functional studies with DYRK1A+/- cardiomyocytes show that this kinase may be an important target to treat cardiac dysfunction, provided that mutant cells presented a different response to stretch and reduced ability to develop force (active tension). This study opens many avenues in post-aortic valve replacement reverse remodeling research. In the future, gain-of-function and/or loss-of-function studies with isolated cardiomyocytes or with animal models of aortic bandingdebanding will help disclose the efficacy of targeting the surrogate therapeutic targets. Besides, clinical studies in larger cohorts will bring definitive proof of complement C3, MuRF1 and DYRK1A prognostic value.A substituição da válvula aórtica continua a ser a opção terapêutica de referência para doentes com estenose aórtica e visa a eliminação da sobrecarga de pressão, desencadeando a remodelagem reversa miocárdica. Contudo, apesar do benefício hemodinâmico imediato, nem todos os pacientes apresentam regressão completa da hipertrofia do miocárdio, ficando com maior risco de eventos adversos, como a insuficiência cardíaca. Atualmente, os mecanismos biológicos subjacentes a uma remodelagem reversa incompleta ainda não são claros. Além disso, não dispomos de ferramentas de prognóstico definitivos nem de terapias auxiliares para melhorar a condição dos pacientes indicados para substituição da válvula. Para ajudar a resolver estas lacunas, uma abordagem combinada de (fosfo)proteómica e proteómica para a caracterização, respetivamente, do miocárdio e do líquido pericárdico foi seguida, tomando partido de biópsias e líquidos pericárdicos recolhidos em ambiente cirúrgico. Das mais de 1800 e 750 proteínas identificadas, respetivamente, no miocárdio e no líquido pericárdico dos pacientes com estenose aórtica, um total de 90 proteínas desreguladas foram detetadas. As análises de anotação de genes, de enriquecimento de vias celulares e discriminativa corroboram um cenário de aumento da expressão de genes pro-hipertróficos e de síntese proteica, um sistema ubiquitina-proteassoma ineficiente, uma tendência para morte celular (potencialmente acelerada pela atividade do complemento e por outros fatores extrínsecos que ativam death receptors), com ativação da resposta de fase aguda e do sistema imune, assim como da fibrose. A validação de alguns alvos específicos através de immunoblot e correlação com dados clínicos apontou para a cadeia β do complemento C3, a Muscle Ring Finger protein 1 (MuRF1) e a dual-specificity Tyr-phosphoylation regulated kinase 1A (DYRK1A) como potenciais marcadores de uma resposta incompleta. Por outro lado, a predição de cinases a partir do fosfoproteoma, sugere que a modulação da caseína cinase 2, a família de cinases do IκB, a glicogénio sintase cinase 3 e da DYRK1A pode ajudar a melhorar a condição dos pacientes indicados para intervenção. Em particular, a avaliação funcional de cardiomiócitos DYRK1A+/- mostraram que esta cinase pode ser um alvo importante para tratar a disfunção cardíaca, uma vez que os miócitos mutantes responderam de forma diferente ao estiramento e mostraram uma menor capacidade para desenvolver força (tensão ativa). Este estudo levanta várias hipóteses na investigação da remodelagem reversa. No futuro, estudos de ganho e/ou perda de função realizados em cardiomiócitos isolados ou em modelos animais de banding-debanding da aorta ajudarão a testar a eficácia de modular os potenciais alvos terapêuticos encontrados. Além disso, estudos clínicos em coortes de maior dimensão trarão conclusões definitivas quanto ao valor de prognóstico do complemento C3, MuRF1 e DYRK1A.Programa Doutoral em Biomedicin

    Epilepsy Mortality: Leading Causes of Death, Co-morbidities, Cardiovascular Risk and Prevention

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    a reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA/1 mouse model of sudden unexpected ... Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by ..

    Physical phenomena controlling quiescent flame spread in porous wildland fuel beds

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    Despite well-developed solid surface flame spread theories, we still lack a coherent theory to describe flame spread through porous wildland fuel beds. This porosity results in additional complexity, reducing the thermal conductivity of the fuel bed, but allowing in-bed radiative and convective heat transfer to occur. While previous studies have explored the effect of fuel bed structure on the overall fire behaviour, there remains a need for further investigation of the effect of fuel structure on the underlying physical phenomena controlling flame spread. Through an extensive series of laboratory-based experiments, this thesis provides detailed, physics-based insights for quiescent flame spread through natural porous beds, across a range of structural conditions. Measurements are presented for fuel beds representative of natural field conditions within an area of the fire-prone New Jersey Pinelands National Reserve, which compliment a related series of field experiments conducted as part of a wider research project. Additional systematic investigation across a wider range of fuel conditions identified independent effects of fuel loading and bulk density on the spread rate, flame height and heat release rate. However, neither fuel loading nor bulk density alone provided adequate prediction of the resulting fire behaviour. Drawing on existing structural descriptors (for both natural and engineered fuel beds) an alternative parameter ασδ was proposed. This parameter (incorporating the fuel bed porosity (α), fuel element surface-to-volume ratio (σ), and the fuel bed height (δ)) was strongly correlated with the spread rate. One effect of the fuel bed structure is to influence the heat transfer mechanisms both above and within the porous fuel bed. Existing descriptions of radiation transport through porous fuel beds are often predicated on the assumption of an isotropic fuel bed. However, given their preferential angle of inclination, the pine needle beds in this study may not exhibit isotropic behaviour. Regardless, for the structural conditions investigated, horizontal heat transfer through the fuel bed was identified as the dominant heating mechanism within this quiescent flame spread scenario. However, the significance of heat transfer contributions from the above-bed flame generally increased with increasing ασδ value of the fuel bed. Using direct measurements of the heat flux magnitude and effective heating distance, close agreement was observed between experimentally observed spread rates and a simple thermal model considering only radiative heat transfer through the fuel bed, particularly at lower values of ασδ. Over-predictions occurred at higher ασδ values, or where other heat transfer terms were incorporated, which may highlight the need to include additional heat loss terms. A significant effect of fuel structure on the primary flow regimes, both within and above these porous fuel beds, was also observed, with important implications for the heat transfer and oxygen supply within the fuel bed. Independent effects of fuel loading and bulk density on both the buoyant and buoyancy-driven entrainment flow were observed, with a complex feedback cycle occurring between Heat Release Rate (HRR) and combustion behaviour. Generally, increases in fuel loading resulted in increased HRR, and therefore increased buoyant flow velocity, along with an increase in the velocity of flow entrained towards the combustion region. The complex effects of fuel structure in both the flaming and smouldering combustion phases may necessitate modifications to other common modelling approaches. The widely used Rothermel model under-predicted spread rate for higher bulk density and lower ασδ fuel beds. As previously suggested, an over-sensitivity to fuel bed height was observed, with experimental comparison indicating an under-prediction of reaction intensity at lower fuel heights. These findings have important implications particularly given the continuing widespread use of the Rothermel model, which continues to underpin elements of the BehavePlus fire modelling system and the US National Fire Danger Rating System. The physical insights, and modelling approaches, developed for this low-intensity, quiescent flame spread scenario, are applicable to common prescribed fire activities. It is hoped that this work (alongside complimentary laboratory and field experiments conducted by various authors as part of a wider multi-agency project (SERDP-RC2641)) will contribute to the emerging field of prescribed fire science, and help to address the pressing need for further development of fire prediction and modelling tools

    Response of saline reservoir to different phaseCO₂-brine: experimental tests and image-based modelling

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    Geological CO₂ storage in saline rocks is a promising method for meeting the target of net zero emission and minimizing the anthropogenic CO₂ emitted into the earth’s atmosphere. Storage of CO₂ in saline rocks triggers CO₂-brine-rock interaction that alters the properties of the rock. Properties of rocks are very crucial for the integrity and efficiency of the storage process. Changes in properties of the reservoir rocks due to CO₂-brine-rock interaction must be well predicted, as some changes can reduce the storage integrity of the reservoir. Considering the thermodynamics, phase behavior, solubility of CO₂ in brine, and the variable pressure-temperature conditions of the reservoir, there will be undissolved CO₂ in a CO₂ storage reservoir alongside the brine for a long time, and there is a potential for phase evolution of the undissolved CO₂. The phase of CO₂ influence the CO₂-brine-rock interaction, different phaseCO₂-brine have a unique effect on the properties of the reservoir rocks, Therefore, this study evaluates the effect of four different phaseCO₂-brine reservoir states on the properties of reservoir rocks using experimental and image-based approach. Samples were saturated with the different phaseCO₂-brine, then subjected to reservoir conditions in a triaxial compression test. The representative element volume (REV)/representative element area (REA) for the rock samples was determined from processed digital images, and rock properties were evaluated using digital rock physics and rock image analysis techniques. This research has evaluated the effect of different phaseCO₂-brine on deformation rate and deformation behavior, bulk modulus, compressibility, strength, and stiffness as well as porosity and permeability of sample reservoir rocks. Changes in pore geometry properties, porosity, and permeability of the rocks in CO₂ storage conditions with different phaseCO₂-brine have been evaluated using digital rock physics techniques. Microscopic rock image analysis has been applied to provide evidence of changes in micro-fabric, the topology of minerals, and elemental composition of minerals in saline rocks resulting from different phaseCO₂-br that can exist in a saline CO₂ storage reservoir. It was seen that the properties of the reservoir that are most affected by the scCO₂-br state of the reservoir include secondary fatigue rate, bulk modulus, shear strength, change in the topology of minerals after saturation as well as change in shape and flatness of pore surfaces. The properties of the reservoir that is most affected by the gCO₂-br state of the reservoir include primary fatigue rate, change in permeability due to stress, change in porosity due to stress, and change topology of minerals due to stress. For all samples, the roundness and smoothness of grains as well as smoothness of pores increased after compression while the roundness of pores decreased. Change in elemental composition in rock minerals in CO₂-brine-rock interaction was seen to depend on the reactivity of the mineral with CO₂ and/or brine and the presence of brine accelerates such change. Carbon, oxygen, and silicon can be used as index minerals for elemental changes in a CO₂-brine-rock system. The result of this work can be applied to predicting the effect the different possible phases of CO₂ will have on the deformation, geomechanics indices, and storage integrity of giant CO₂ storage fields such as Sleipner, In Salah, etc

    The Role of the Metabolome in the Development of Gestational Diabetes Mellitus in High-Risk Minority Women: A Causal Investigation

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    Gestational Diabetes Mellitus (GDM) is the most common pregnancy complication worldwide. However, GDM prevalence is substantially lower in white Europeans (WEs) compared to other ethnicities, especially South Asians (SAs) who experience the highest risk. Globally, healthy diet promotion is the mainstay in GDM prevention, however current guidelines are predominantly based on evidence from WEs. Furthermore, metabolic factors responsible for the disparities in prevalence are unknown but may offer guidance for improved prevention and management. This project aimed to (i) assess the association between diet and GDM across ethnic groups, (ii) determine if distinct metabolic profiles characterise GDM in SAs and WEs, and (iii) evaluate the presence of ethnic-specific causal associations between metabolites and gestational dysglycemia. Aims (ii) and (iii) utilised data from the Born in Bradford cohort (mean gestational age 26.1 weeks). First, through a systematic review of observational and randomised studies, pre-pregnancy diet was found to associate with GDM in WEs, but not in Asians. Secondly, the multivariate analyses of metabolites identified 7 metabolites that were characteristic of GDM in both ethnicities, with an additional 6 characteristic in WEs only. Finally, through Mendelian Randomisation (MR) analyses, 14 metabolites associated with pregnancy dysglycemia in WEs and 11 in SAs. No metabolites were identified in both ethnicities. Cholesterols and fatty acids were the most commonly identified classes identified in WEs and SAs, respectively. This project demonstrated (i) inconsistencies in the association between diet and GDM across ethnicities (ii) distinct metabolic profiles that associate with GDM in WEs and SAs and offers and supports the need for ethnic-specific manage GDM management strategies. In high-risk SAs, fatty acids may be the most important predictors of GDM. Future work should evaluate the role of pre-pregnancy fatty acid intake in GDM development in SAs to aid in the development of culturally tailored dietary interventions

    II tüüpi kollageeni neoepitoop C2C uriinis kui põlve osteoartriidi diagnoosimise ja kulu prognoosimise biomarker

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    Väitekirja elektrooniline versioon ei sisalda publikatsiooneOsteoartriit (OA) on sagedasim liigeshaigus, tabades ligi poolt miljardit inimest maailmas. Põlv on üks peamisi kahjustuskohti. Haiguse kaasaegse käsitluse järgi arenevad kahjustused molekulaarsetest muutustest kuni kudede (kõhr, luu, sünoviaalkest, menisk, sidemed) struktuuri muutusteni. OA on aastate jooksul ebaühtlase kiirusega süvenev haigus, mille puhul stabiilsemad perioodid vahelduvad kiiremate muutustega, kulgedes varajases järgus haigustunnusteta. Seetõttu pakuvad kudede ainevahetuse muutusi peegeldavad molekulaarsed markerid varajast hoiatust koekahjustuse tekkest, võimalust hinnata haiguse kulgu ning tulevikus ka ravivastust. Kuna II tüüpi kollageen (Kol2) on kõhre peamine struktuurne komponent, on OA hindamiseks loodud mitmeid Kol2 lammutamist mõõtvaid teste. Käesolevas uurimuses hindasime OA uue biomarkeri, uC2C kasutusvõimalusi põlve OA (pOA) korral. uC2C on Kol2 lõhustumise neoepitoop C2C uriinis. Võrdlesime uC2C väärtusi röntgenleiu, kõhre otsese vaatlusleiu ja patsiendi kliinilise seisundiga, kasutades erinevaid statistilisi mudeleid. Selgus, et uC2C on sobiv kandidaat pOA varajase diagnostilise testi arendamiseks. C2C sisaldus tõuseb juba haiguse varajases järgus ja on seotud haiguse mitme põhiprotsessiga: kõhre lammutamise ja luukasviste tekkega põlveliigese eri osades. uC2C on hea progressioonimarker naistel: uC2C kõrgem algväärtus ennustab naistel väga hästi (>90%) pOA teket või süvenemist järgneva 3 aasta jooksul. uC2C tase on kõrgem suuremate röntgenmuutuste korral, seega uC2C tase on seotud pOA raskusastmega. uC2C väärtused on suurimad kOA lõppjärgus olevatel haigetel, kes jõuavad liigeseasenduseni suhteliselt noorelt (50–70 a vanuses). Pärast põlveliigese asendamist võib C2C eritumine uriiniga väheneda, suureneda või jääda muutumatuks. Seega ei peata liigeseasendus paljudel juhtudel Kol2 lammutamist organismis ja OA on süsteemsem haigus, kui on seni arvatud. uC2C näib olevat naistel võrreldes meestega parem pOA biomarker.Osteoarthritis (OA) is the most common joint disease, affecting about half a billion people worldwide. The knee is one of the main sites of impairment. According to the new approach to the disease, the alterations develop from the molecular level to structural changes in tissues (cartilage, bone, synovium, meniscus, ligaments). OA is a disease with an alternating course, with no signs of disease at an early stage. Therefore, molecular markers that reflect changes in tissue metabolism provide an early warning of tissue damage, an opportunity to assess the course of the disease, and a response to future treatment. Because type II collagen (Col2) is a major structural component of cartilage, several tests have been developed to measure Col2 degradation. In the current study, we evaluated the potential use of a new OA biomarker, C2C, in knee OA (kOA). uC2C is a Col2 cleavage neoepitope in urine. We compared uC2C values with X-ray findings, direct visual assessment of cartilage, and clinical status using different statistical models. uC2C is a good candidate for the development of an early diagnostic test for kOA. The level of uC2C is increased in the early stages of kOA and is related to several main processes of kOA: the cartilage lesions and the osteophytes in distinct knee compartments. uC2C is a good marker of progression in women–a higher baseline uC2C is an excellent predictor (> 90%) of the initiation or worsening of kOA over the next 3 years. uC2C is higher in higher X-ray grades, so uC2C levels are associated with the severity of kOA. uC2C values are highest in patients with end-stage kOA who reach joint replacement at a relatively young age (50-70 years). After knee replacement, urinary excretion of C2C may decrease, increase, or remain unchanged. Thus, in many cases, joint replacement does not stop the breakdown of Col2 in the body, and OA is a more systemic disease than previously thought. uC2C appears to be a better biomarker of pOA in women than in men.https://www.ester.ee/record=b550707

    A mixed-methods study on L2 motivation of Korean junior college English major students

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    Korea is an EFL context where instrumentality overpowers integrativeness for college entrance or employment because English is mainly considered a school or test subject. Integrativeness might be replaceable due to its inadequacy of explaining how L2 learners integrate into a certain L2 community in the globalized world. Thus, Dörnyei (2005, 2009a) developed the L2 Motivational Self System (L2MSS) that could encompass both integrativeness and instrumentality as in the ideal L2 self. The L2MSS is a future-oriented tripartite framework to comprise the ideal L2 self, ought-to L2 self, and L2 learning experience. There might be fluctuations or even surges in L2 motivation, which the new model has gained validity in its dynamic nature and imagery capacity (Dörnyei, 2010b). Thus, this study attempted to discover the dynamics of L2 motivation employing L2MSS as the main framework. Nevertheless, Korean learners of English could learn English without their L2 motivation (Kim, T.-Y., 2012b). This trend might go until or after tertiary education. Also, there has been academic elitism, hakbul, in Korea, to distinguish four-year universities and two- or three-year junior colleges, which are frequently considered second-choice or failure. Thus, this study explored junior college students, especially those majoring in English, who were studied less than four-year university students. Assuming junior college English major students’ L2 motivation is unique on their own, a longitudinal mixed-methods case study will be employed using the L2MSS. 189 students participated in the online questionnaire administration, followed by interviews with 59 and 31 students and five professors. The participants showed some L2 motivation with Korea-specific tendencies in that there was intense pressure for the future. Most significantly, there were weak ideal L2 self, strong ought-to L2 self, and universal concept of instrumentality (promotion). Therefore, this study offers pedagogical implications to complement their current L2 learning and motivation
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