Technology 2001: The Second National Technology Transfer Conference and Exposition, volume 2

Proceedings of the workshop are presented. The mission of the conference was to transfer advanced technologies developed by the Federal government, its contractors, and other high-tech organizations to U.S. industries for their use in developing new or improved products and processes. Volume two presents papers on the following topics: materials science, robotics, test and measurement, advanced manufacturing, artificial intelligence, biotechnology, electronics, and software engineering

NASA patent abstracts bibliography: A continuing bibliography. Section 2: Indexes (supplement 14)

This issue of the Index Section contains entries for 3512 patent and applications for patent citations covering the period May 1969 through December 1978. The Index Section contains five indexes --- subject, inventor, source, number, and accession number

A complex systems approach to education in Switzerland

The insights gained from the study of complex systems in biological, social, and engineered systems enables us not only to observe and understand, but also to actively design systems which will be capable of successfully coping with complex and dynamically changing situations. The methods and mindset required for this approach have been applied to educational systems with their diverse levels of scale and complexity. Based on the general case made by Yaneer Bar-Yam, this paper applies the complex systems approach to the educational system in Switzerland. It confirms that the complex systems approach is valid. Indeed, many recommendations made for the general case have already been implemented in the Swiss education system. To address existing problems and difficulties, further steps are recommended. This paper contributes to the further establishment complex systems approach by shedding light on an area which concerns us all, which is a frequent topic of discussion and dispute among politicians and the public, where billions of dollars have been spent without achieving the desired results, and where it is difficult to directly derive consequences from actions taken. The analysis of the education system's different levels, their complexity and scale will clarify how such a dynamic system should be approached, and how it can be guided towards the desired performance

Psr1p interacts with SUN/sad1p and EB1/mal3p to establish the bipolar spindle

Regular Abstracts - Sunday Poster Presentations: no. 382During mitosis, interpolar microtubules from two spindle pole bodies (SPBs) interdigitate to create an antiparallel microtubule array for accommodating numerous regulatory proteins. Among these proteins, the kinesin-5 cut7p/Eg5 is the key player responsible for sliding apart antiparallel microtubules and thus helps in establishing the bipolar spindle. At the onset of mitosis, two SPBs are adjacent to one another with most microtubules running nearly parallel toward the nuclear envelope, creating an unfavorable microtubule configuration for the kinesin-5 kinesins. Therefore, how the cell organizes the antiparallel microtubule array in the first place at mitotic onset remains enigmatic. Here, we show that a novel protein psrp1p localizes to the SPB and plays a key role in organizing the antiparallel microtubule array. The absence of psr1+ leads to a transient monopolar spindle and massive chromosome loss. Further functional characterization demonstrates that psr1p is recruited to the SPB through interaction with the conserved SUN protein sad1p and that psr1p physically interacts with the conserved microtubule plus tip protein mal3p/EB1. These results suggest a model that psr1p serves as a linking protein between sad1p/SUN and mal3p/EB1 to allow microtubule plus ends to be coupled to the SPBs for organization of an antiparallel microtubule array. Thus, we conclude that psr1p is involved in organizing the antiparallel microtubule array in the first place at mitosis onset by interaction with SUN/sad1p and EB1/mal3p, thereby establishing the bipolar spindle.postprin

Removal of antagonistic spindle forces can rescue metaphase spindle length and reduce chromosome segregation defects

Regular Abstracts - Tuesday Poster Presentations: no. 1925Metaphase describes a phase of mitosis where chromosomes are attached and oriented on the bipolar spindle for subsequent segregation at anaphase. In diverse cell types, the metaphase spindle is maintained at a relatively constant length. Metaphase spindle length is proposed to be regulated by a balance of pushing and pulling forces generated by distinct sets of spindle microtubules and their interactions with motors and microtubule-associated proteins (MAPs). Spindle length appears important for chromosome segregation fidelity, as cells with shorter or longer than normal metaphase spindles, generated through deletion or inhibition of individual mitotic motors or MAPs, showed chromosome segregation defects. To test the force balance model of spindle length control and its effect on chromosome segregation, we applied fast microfluidic temperature-control with live-cell imaging to monitor the effect of switching off different combinations of antagonistic forces in the fission yeast metaphase spindle. We show that spindle midzone proteins kinesin-5 cut7p and microtubule bundler ase1p contribute to outward pushing forces, and spindle kinetochore proteins kinesin-8 klp5/6p and dam1p contribute to inward pulling forces. Removing these proteins individually led to aberrant metaphase spindle length and chromosome segregation defects. Removing these proteins in antagonistic combination rescued the defective spindle length and, in some combinations, also partially rescued chromosome segregation defects. Our results stress the importance of proper chromosome-to-microtubule attachment over spindle length regulation for proper chromosome segregation.postprin

The development of a theory of life-environment disruption to account for the phenomenon of premature morbidities and mortalities associated with a radical change in a person’s living environment

The thesis originates in an unresolved phenomenon associated with moving into a nursing home and concerns the reports of emotional distress, depression and increased risk of morbidity and mortality associated with the move; shedding-life is used to capture the broad character of this phenomenon. Shedding-life has been the subject of scientific inquiry for seventy years and yet the phenomenon is still not understood and, possibly because of this, there appears to be no generally accepted approaches to ameliorate this harm. This thesis inquiries into the genesis of shedding life and presents a theory to account for it. The failure of existing research to account for shedding-life indicated an alternative approach was required. As shedding-life arises in the context of a significant change in a person’s living-environment it was surmised that the phenomenon involves the relationship between the person and the changing environment in which they live. Based on this, the approach taken was to use the philosophical research of Martin Heidegger concerning the structural relationship between the person and their living environment, an approach not previously explored. Heidegger’s research, undertaken within the empiricist tradition, identifies and describes the structural processes by which the person is both constituted by its formative socio-cultural environment and bound to it as the locus and source of its ongoing existence. This means that who the individual human person becomes is both contingent and dependent upon the living environment into which it is born and raised, where the concept of living environment is understood in terms of possibilities for a meaningful life. On this account if a person’s access to their living environment is materially disrupted they are at risk of experiencing a decline in the meaningfulness of their existence. As this is a naturalistic account, founded on the biological processes of the body, the loss of an appropriate living environment is reflected in psychological distress which in turn is frequently manifested in bodily morbidities; this is the basis of shedding life, a structural rather than a psychological phenomenon. This contingent account of the person is in stark contrast to the materialist approach that posits the person as essentially the biological body, independent of its environment. The materialist view informs the design and running of nursing homes resulting in a significant disruption to a person’s life-environment contributing to rather than ameliorating shedding-life, as such nursing homes are iatrogenic, i.e. cause harm. Left unaddressed nursing home environments will continue to cause harm and fail to assist older people live a meaningful life in their remaining years. While the thesis commenced from a concern about nursing homes, the phenomenon of shedding-life is a much broader phenomenon. The Theory of Life- Environment Disruption, derived from the structure of being a person, provides an account of shedding-life by identifying the essential relationship between the person and their life-environment. The theory predicts that whenever there is a material disruption to a person’s life-environment they are at risk of shedding life and as such the theory has broad applicability for human affairs more generallyThesis (Ph.D.) -- University of Adelaide, The Joanna Briggs Institute, 201

Tematski zbornik radova međunarodnog značaja. Tom 3 / Međunarodni naučni skup “Dani Arčibalda Rajsa”, Beograd, 3-4. mart 2015.

In front of you is the Thematic Collection of Papers presented at the International Scientific Confer-ence “Archibald Reiss Days”, which was organized by the Academy of Criminalistic and Police Studies in Belgrade, in co-operation with the Ministry of Interior and the Ministry of Education, Science and Techno-logical Development of the Republic of Serbia, National Police University of China, Lviv State University of Internal Affairs, Volgograd Academy of the Russian Internal Affairs Ministry, Faculty of Security in Skopje, Faculty of Criminal Justice and Security in Ljubljana, Police Academy “Alexandru Ioan Cuza“ in Bucharest, Academy of Police Force in Bratislava and Police College in Banjaluka, and held at the Academy of Crimi-nalistic and Police Studies, on 3 and 4 March 2015.International Scientific Conference “Archibald Reiss Days” is organized for the fifth time in a row, in memory of the founder and director of the first modern higher police school in Serbia, Rodolphe Archibald Reiss, PhD, after whom the Conference was named.The Thematic Collection of Papers contains 168 papers written by eminent scholars in the field of law, security, criminalistics, police studies, forensics, informatics, as well as members of national security system participating in education of the police, army and other security services from Spain, Russia, Ukraine, Bela-rus, China, Poland, Armenia, Portugal, Turkey, Austria, Slovakia, Hungary, Slovenia, Macedonia, Croatia, Montenegro, Bosnia and Herzegovina, Republic of Srpska and Serbia. Each paper has been reviewed by two reviewers, international experts competent for the field to which the paper is related, and the Thematic Conference Proceedings in whole has been reviewed by five competent international reviewers.The papers published in the Thematic Collection of Papers contain the overview of contemporary trends in the development of police education system, development of the police and contemporary secu-rity, criminalistic and forensic concepts. Furthermore, they provide us with the analysis of the rule of law activities in crime suppression, situation and trends in the above-mentioned fields, as well as suggestions on how to systematically deal with these issues. The Collection of Papers represents a significant contribution to the existing fund of scientific and expert knowledge in the field of criminalistic, security, penal and legal theory and practice. Publication of this Collection contributes to improving of mutual cooperation between educational, scientific and expert institutions at national, regional and international level