30,325 research outputs found
A fast and robust patient specific Finite Element mesh registration technique: application to 60 clinical cases
Finite Element mesh generation remains an important issue for patient
specific biomechanical modeling. While some techniques make automatic mesh
generation possible, in most cases, manual mesh generation is preferred for
better control over the sub-domain representation, element type, layout and
refinement that it provides. Yet, this option is time consuming and not suited
for intraoperative situations where model generation and computation time is
critical. To overcome this problem we propose a fast and automatic mesh
generation technique based on the elastic registration of a generic mesh to the
specific target organ in conjunction with element regularity and quality
correction. This Mesh-Match-and-Repair (MMRep) approach combines control over
the mesh structure along with fast and robust meshing capabilities, even in
situations where only partial organ geometry is available. The technique was
successfully tested on a database of 5 pre-operatively acquired complete femora
CT scans, 5 femoral heads partially digitized at intraoperative stage, and 50
CT volumes of patients' heads. The MMRep algorithm succeeded in all 60 cases,
yielding for each patient a hex-dominant, Atlas based, Finite Element mesh with
submillimetric surface representation accuracy, directly exploitable within a
commercial FE software
Prostate Biopsy Assistance System with Gland Deformation Estimation for Enhanced Precision
Computer-assisted prostate biopsies became a very active research area during
the last years. Prostate tracking makes it possi- ble to overcome several
drawbacks of the current standard transrectal ultrasound (TRUS) biopsy
procedure, namely the insufficient targeting accuracy which may lead to a
biopsy distribution of poor quality, the very approximate knowledge about the
actual location of the sampled tissues which makes it difficult to implement
focal therapy strategies based on biopsy results, and finally the difficulty to
precisely reach non-ultrasound (US) targets stemming from different modalities,
statistical atlases or previous biopsy series. The prostate tracking systems
presented so far are limited to rigid transformation tracking. However, the
gland can get considerably deformed during the intervention because of US probe
pres- sure and patient movements. We propose to use 3D US combined with
image-based elastic registration to estimate these deformations. A fast elastic
registration algorithm that copes with the frequently occurring US shadows is
presented. A patient cohort study was performed, which yielded a statistically
significant in-vivo accuracy of 0.83+-0.54mm.Comment: This version of the paper integrates a correction concerning the
local similarity measure w.r.t. the proceedings (this typing error could not
be corrected before editing the proceedings
Search for the Cryptoexotic Member of the Baryon Antidecuplet 1/2+ in the Reactions pi- p --> pi- p and pi- p --> K L
The main goal of this proposal is the search for a narrow cryptoexotic
nucleon resonance by scanning of the pi- p system invariant mass in the region
(1610-1770) MeV with the detection of pi- p and K Lambda decays. The scan is
supposed to be done by the variation of the incident pi- momentum and its
measurement with the accuracy of up to +-0.1% (better than 1 MeV in terms of
the invariant mass in the whole energy range) with a set of proportional
chambers located in the first focus of the magnetooptical channel. High
sensitivity of the method to the resonance under search is shown. The secondary
particles scattered from a liquid hydrogen target are detected by sets of the
wire drift chambers equipped with modern electronics. The time scale of the
project is about 3 years. The budget estimate including manpower, the apparatus
and operation cost, is about 40 million rubles. The beam time required is (4-6)
two week runs on "high" (10 GeV/c) flattop of the ITEP proton synchrotron.Comment: 16 pages, 10 figures. v2: an acknowledge adde
Registration of brain tumor images using hyper-elastic regularization
In this paper, we present a method to estimate a deformation
field between two instances of a brain volume having tumor. The novelties
include the assessment of the disease progress by observing the healthy tissue
deformation and usage of the Neo-Hookean strain energy density model as
a regularizer in deformable registration framework. Implementations on synthetic
and patient data provide promising results, which might have relevant
use in clinical problems
Finite element surface registration incorporating curvature, volume preservation, and statistical model information
We present a novel method for nonrigid registration of 3D surfaces and images. The method can be used to register surfaces by means of their distance images, or to register medical images directly. It is formulated as a minimization problem of a sum of several terms representing the desired properties of a registration result: smoothness, volume preservation, matching of the surface, its curvature, and possible other feature images, as well as consistency with previous registration results of similar objects, represented by a statistical deformation model. While most of these concepts are already known, we present a coherent continuous formulation of these constraints, including the statistical deformation model. This continuous formulation renders the registration method independent of its discretization. The finite element discretization we present is, while independent of the registration functional, the second main contribution of this paper. The local discontinuous Galerkin method has not previously been used in image registration, and it provides an efficient and general framework to discretize each of the terms of our functional. Computational efficiency and modest memory consumption are achieved thanks to parallelization and locally adaptive mesh refinement. This allows for the first time the use of otherwise prohibitively large 3D statistical deformation models
MRI/TRUS data fusion for brachytherapy
BACKGROUND: Prostate brachytherapy consists in placing radioactive seeds for
tumour destruction under transrectal ultrasound imaging (TRUS) control. It
requires prostate delineation from the images for dose planning. Because
ultrasound imaging is patient- and operator-dependent, we have proposed to fuse
MRI data to TRUS data to make image processing more reliable. The technical
accuracy of this approach has already been evaluated. METHODS: We present work
in progress concerning the evaluation of the approach from the dosimetry
viewpoint. The objective is to determine what impact this system may have on
the treatment of the patient. Dose planning is performed from initial TRUS
prostate contours and evaluated on contours modified by data fusion. RESULTS:
For the eight patients included, we demonstrate that TRUS prostate volume is
most often underestimated and that dose is overestimated in a correlated way.
However, dose constraints are still verified for those eight patients.
CONCLUSIONS: This confirms our initial hypothesis
Seismic Ray Impedance Inversion
This thesis investigates a prestack seismic inversion scheme implemented in the ray
parameter domain. Conventionally, most prestack seismic inversion methods are
performed in the incidence angle domain. However, inversion using the concept of
ray impedance, as it honours ray path variation following the elastic parameter
variation according to Snellâs law, shows the capacity to discriminate different
lithologies if compared to conventional elastic impedance inversion.
The procedure starts with data transformation into the ray-parameter domain and then
implements the ray impedance inversion along constant ray-parameter profiles. With
different constant-ray-parameter profiles, mixed-phase wavelets are initially estimated
based on the high-order statistics of the data and further refined after a proper well-to-seismic
tie. With the estimated wavelets ready, a Cauchy inversion method is used to
invert for seismic reflectivity sequences, aiming at recovering seismic reflectivity
sequences for blocky impedance inversion. The impedance inversion from reflectivity
sequences adopts a standard generalised linear inversion scheme, whose results are
utilised to identify rock properties and facilitate quantitative interpretation. It has also
been demonstrated that we can further invert elastic parameters from ray impedance
values, without eliminating an extra density term or introducing a Gardnerâs relation
to absorb this term.
Ray impedance inversion is extended to P-S converted waves by introducing the
definition of converted-wave ray impedance. This quantity shows some advantages in
connecting prestack converted wave data with well logs, if compared with the shearwave
elastic impedance derived from the Aki and Richards approximation to the
Zoeppritz equations. An analysis of P-P and P-S wave data under the framework of
ray impedance is conducted through a real multicomponent dataset, which can reduce
the uncertainty in lithology identification.Inversion is the key method in generating those examples throughout the entire thesis
as we believe it can render robust solutions to geophysical problems. Apart from the
reflectivity sequence, ray impedance and elastic parameter inversion mentioned above,
inversion methods are also adopted in transforming the prestack data from the offset
domain to the ray-parameter domain, mixed-phase wavelet estimation, as well as the
registration of P-P and P-S waves for the joint analysis.
The ray impedance inversion methods are successfully applied to different types of
datasets. In each individual step to achieving the ray impedance inversion, advantages,
disadvantages as well as limitations of the algorithms adopted are detailed. As a
conclusion, the ray impedance related analyses demonstrated in this thesis are highly
competent compared with the classical elastic impedance methods and the author
would like to recommend it for a wider application
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