Scalable Feature Selection Applications for Genome-Wide Association Studies of Complex Diseases

Personalized medicine will revolutionize our capabilities to combat disease. Working toward this goal, a fundamental task is the deciphering of geneticvariants that are predictive of complex diseases. Modern studies, in the formof genome-wide association studies (GWAS) have afforded researchers with the opportunity to reveal new genotype-phenotype relationships through the extensive scanning of genetic variants. These studies typically contain over half a million genetic features for thousands of individuals. Examining this with methods other than univariate statistics is a challenging task requiring advanced algorithms that are scalable to the genome-wide level. In the future, next-generation sequencing studies (NGS) will contain an even larger number of common and rare variants. Machine learning-based feature selection algorithms have been shown to have the ability to effectively create predictive models for various genotype-phenotype relationships. This work explores the problem of selecting genetic variant subsets that are the most predictive of complex disease phenotypes through various feature selection methodologies, including filter, wrapper and embedded algorithms. The examined machine learning algorithms were demonstrated to not only be effective at predicting the disease phenotypes, but also doing so efficiently through the use of computational shortcuts. While much of the work was able to be run on high-end desktops, some work was further extended so that it could be implemented on parallel computers helping to assure that they will also scale to the NGS data sets. Further, these studies analyzed the relationships between various feature selection methods and demonstrated the need for careful testing when selecting an algorithm. It was shown that there is no universally optimal algorithm for variant selection in GWAS, but rather methodologies need to be selected based on the desired outcome, such as the number of features to be included in the prediction model. It was also demonstrated that without proper model validation, for example using nested cross-validation, the models can result in overly-optimistic prediction accuracies and decreased generalization ability. It is through the implementation and application of machine learning methods that one can extract predictive genotype–phenotype relationships and biological insights from genetic data sets.Siirretty Doriast

Efficient Personalized Probabilistic Retrieval of Chinese Calligraphic Manuscript Images in Mobile Cloud Environment

Ancient language manuscripts constitute a key part of the cultural heritage of mankind. As one of the most important languages, Chinese historical calligraphy work has contributed to not only the Chinese cultural heritage but also the world civilization at large, especially for Asia. To support deeper and more convenient appreciation of Chinese calligraphy works, based on our previous work on the probabilistic retrieval of historical Chinese calligraphic character manuscripts repositories, we propose a system framework of the multi-feature-based Chinese calligraphic character images probabilistic retrieval in mobile cloud network environment, which is called the DPRC. To ensure retrieval efficiency, we further propose four enabling techniques: 1) DRL-based probability propagation, 2) optimal data placement scheme, 3) adaptive data robust transmission algorithm, and 4) index support filtering scheme. Comprehensive experiments are conducted to testify the effectiveness and efficiency of our proposed DPRC method

Design revolutions: IASDR 2019 Conference Proceedings. Volume 4: Learning, Technology, Thinking

In September 2019 Manchester School of Art at Manchester Metropolitan University was honoured to host the bi-annual conference of the International Association of Societies of Design Research (IASDR) under the unifying theme of DESIGN REVOLUTIONS. This was the first time the conference had been held in the UK. Through key research themes across nine conference tracks – Change, Learning, Living, Making, People, Technology, Thinking, Value and Voices – the conference opened up compelling, meaningful and radical dialogue of the role of design in addressing societal and organisational challenges. This Volume 4 includes papers from Learning, Technology and Thinking tracks of the conference

WiFi-Based Human Activity Recognition Using Attention-Based BiLSTM

Recently, significant efforts have been made to explore human activity recognition (HAR) techniques that use information gathered by existing indoor wireless infrastructures through WiFi signals without demanding the monitored subject to carry a dedicated device. The key intuition is that different activities introduce different multi-paths in WiFi signals and generate different patterns in the time series of channel state information (CSI). In this paper, we propose and evaluate a full pipeline for a CSI-based human activity recognition framework for 12 activities in three different spatial environments using two deep learning models: ABiLSTM and CNN-ABiLSTM. Evaluation experiments have demonstrated that the proposed models outperform state-of-the-art models. Also, the experiments show that the proposed models can be applied to other environments with different configurations, albeit with some caveats. The proposed ABiLSTM model achieves an overall accuracy of 94.03%, 91.96%, and 92.59% across the 3 target environments. While the proposed CNN-ABiLSTM model reaches an accuracy of 98.54%, 94.25% and 95.09% across those same environments

Exploring Written Artefacts

This collection, presented to Michael Friedrich in honour of his academic career at of the Centre for the Study of Manuscript Cultures, traces key concepts that scholars associated with the Centre have developed and refined for the systematic study of manuscript cultures. At the same time, the contributions showcase the possibilities of expanding the traditional subject of ‘manuscripts’ to the larger perspective of ‘written artefacts’

Exploring Written Artefacts

This collection, presented to Michael Friedrich in honour of his academic career at of the Centre for the Study of Manuscript Cultures, traces key concepts that scholars associated with the Centre have developed and refined for the systematic study of manuscript cultures. At the same time, the contributions showcase the possibilities of expanding the traditional subject of ‘manuscripts’ to the larger perspective of ‘written artefacts’