Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society

Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud \ud \ud KEYWORDS: Emergence of Life and Human Consciousness;\ud Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud \u

From Simple to Complex and Ultra-complex Systems:\ud A Paradigm Shift Towards Non-Abelian Systems Dynamics

Atoms, molecules, organisms distinguish layers of reality because of the causal links that govern their behavior, both horizontally (atom-atom, molecule-molecule, organism-organism) and vertically (atom-molecule-organism). This is the first intuition of the theory of levels. Even if the further development of the theory will require imposing a number of qualifications to this initial intuition, the idea of a series of entities organized on different levels of complexity will prove correct. Living systems as well as social systems and the human mind present features remarkably different from those characterizing non-living, simple physical and chemical systems. We propose that super-complexity requires at least four different categorical frameworks, provided by the theories of levels of reality, chronotopoids, (generalized) interactions, and anticipation

From Simple to Complex and Ultra-complex Systems:\ud A Paradigm Shift Towards Non-Abelian Systems Dynamics

Atoms, molecules, organisms distinguish layers of reality because of the causal links that govern their behavior, both horizontally (atom-atom, molecule-molecule, organism-organism) and vertically (atom-molecule-organism). This is the first intuition of the theory of levels. Even if the further development of the theory will require imposing a number of qualifications to this initial intuition, the idea of a series of entities organized on different levels of complexity will prove correct. Living systems as well as social systems and the human mind present features remarkably different from those characterizing non-living, simple physical and chemical systems. We propose that super-complexity requires at least four different categorical frameworks, provided by the theories of levels of reality, chronotopoids, (generalized) interactions, and anticipation

New Directions in Categorical Logic, for Classical, Probabilistic and Quantum Logic

Intuitionistic logic, in which the double negation law not-not-P = P fails, is dominant in categorical logic, notably in topos theory. This paper follows a different direction in which double negation does hold. The algebraic notions of effect algebra/module that emerged in theoretical physics form the cornerstone. It is shown that under mild conditions on a category, its maps of the form X -> 1+1 carry such effect module structure, and can be used as predicates. Predicates are identified in many different situations, and capture for instance ordinary subsets, fuzzy predicates in a probabilistic setting, idempotents in a ring, and effects (positive elements below the unit) in a C*-algebra or Hilbert space. In quantum foundations the duality between states and effects plays an important role. It appears here in the form of an adjunction, where we use maps 1 -> X as states. For such a state s and a predicate p, the validity probability s |= p is defined, as an abstract Born rule. It captures many forms of (Boolean or probabilistic) validity known from the literature. Measurement from quantum mechanics is formalised categorically in terms of `instruments', using L\"uders rule in the quantum case. These instruments are special maps associated with predicates (more generally, with tests), which perform the act of measurement and may have a side-effect that disturbs the system under observation. This abstract description of side-effects is one of the main achievements of the current approach. It is shown that in the special case of C*-algebras, side-effect appear exclusively in the non-commutative case. Also, these instruments are used for test operators in a dynamic logic that can be used for reasoning about quantum programs/protocols. The paper describes four successive assumptions, towards a categorical axiomatisation of quantitative logic for probabilistic and quantum systems

Introduction to Gestural Similarity in Music. An Application of Category Theory to the Orchestra

Mathematics, and more generally computational sciences, intervene in several aspects of music. Mathematics describes the acoustics of the sounds giving formal tools to physics, and the matter of music itself in terms of compositional structures and strategies. Mathematics can also be applied to the entire making of music, from the score to the performance, connecting compositional structures to acoustical reality of sounds. Moreover, the precise concept of gesture has a decisive role in understanding musical performance. In this paper, we apply some concepts of category theory to compare gestures of orchestral musicians, and to investigate the relationship between orchestra and conductor, as well as between listeners and conductor/orchestra. To this aim, we will introduce the concept of gestural similarity. The mathematical tools used can be applied to gesture classification, and to interdisciplinary comparisons between music and visual arts.Comment: The final version of this paper has been published by the Journal of Mathematics and Musi

Convolution, Separation and Concurrency

A notion of convolution is presented in the context of formal power series together with lifting constructions characterising algebras of such series, which usually are quantales. A number of examples underpin the universality of these constructions, the most prominent ones being separation logics, where convolution is separating conjunction in an assertion quantale; interval logics, where convolution is the chop operation; and stream interval functions, where convolution is used for analysing the trajectories of dynamical or real-time systems. A Hoare logic is constructed in a generic fashion on the power series quantale, which applies to each of these examples. In many cases, commutative notions of convolution have natural interpretations as concurrency operations.Comment: 39 page