The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components

G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily versus interfamily connections. Most of the receptors within the network are linked to each other by a small number of edges. DRD2, OPRM, ADRB2, AA2AR, AA1R, OPRK, OPRD and GHSR are identified as hubs. In a network representation 10 modules/clusters also appear as a highly interconnected group of nodes. Information on this GPCR network can improve our understanding of molecular integration. GPCR-HetNet has been implemented in Java and is freely available at http://www.iiia.csic.es/similar to ismel/GPCR-Nets/index.html

Institutional paraconsciousness and its pathologies

This analysis extends a recent mathematical treatment of the Baars consciousness model to analogous, but far more complicated, phenomena of institutional cognition. Individual consciousness is limited to a single, tunable, giant component of interacting cognitive modules, instantiating a Global Workspace. Human institutions, by contrast, support several, sometimes many, such giant components simultaneously, although their behavior remains constrained to a topology generated by cultural context and by the path-dependence inherent to organizational history. Such highly parallel multitasking - institutional paraconsciousness - while clearly limiting inattentional blindness and the consequences of failures within individual workspaces, does not eliminate them, and introduces new characteristic dysfunctions involving the distortion of information sent between global workspaces. Consequently, organizations (or machines designed along these principles), while highly efficient at certain kinds of tasks, remain subject to canonical and idiosyncratic failure patterns similar to, but more complicated than, those afflicting individuals. Remediation is complicated by the manner in which pathogenic externalities can write images of themselves on both institutional function and therapeutic intervention, in the context of relentless market selection pressures. The approach is broadly consonant with recent work on collective efficacy, collective consciousness, and distributed cognition

Sheaf Theory as a Foundation for Heterogeneous Data Fusion

A major impediment to scientific progress in many fields is the inability to make sense of the huge amounts of data that have been collected via experiment or computer simulation. This dissertation provides tools to visualize, represent, and analyze the collection of sensors and data all at once in a single combinatorial geometric object. Encoding and translating heterogeneous data into common language are modeled by supporting objects. In this methodology, the behavior of the system based on the detection of noise in the system, possible failure in data exchange and recognition of the redundant or complimentary sensors are studied via some related geometric objects. Applications of the constructed methodology are described by two case studies: one from wildfire threat monitoring and the other from air traffic monitoring. Both cases are distributed (spatial and temporal) information systems. The systems deal with temporal and spatial fusion of heterogeneous data obtained from multiple sources, where the schema, availability and quality vary. The behavior of both systems is explained thoroughly in terms of the detection of the failure in the systems and the recognition of the redundant and complimentary sensors. A comparison between the methodology in this dissertation and the alternative methods is described to further verify the validity of the sheaf theory method. It is seen that the method has less computational complexity in both space and time