In-body to On-body Experimental UWB Channel Characterization for the Human Gastrointestinal Area

[ES] La población mundial en países desarrollados está envejeciendo y con ello existe un aumento de enfermedades en gran medida causadas por la edad. Las nuevas tecnologías médicas pueden ayudar a detectar, diagnosticar y tratar estas enfermedades y con ello ahorrar dinero, tiempo y recursos de los sistemas sanitarios. Las tecnologías inalámbricas implantables han abierto un nuevo panorama para la próxima generación de tecnologías médicas. Frecuencias como la Ultra Wide-Band (UWB) de 3.1 a 10.6 GHz están siendo consideradas para la nueva generación de dispositivos inalámbricos para dentro del cuerpo humano. Las características como el reducido tamaño de las antenas, la baja potencia de transmisión y la alta velocidad de datos son las más buscadas en este tipo de dispositivos. El problema surge porque el cuerpo humano depende de la frecuencia de modo que a mayores frecuencias, mayores son las pérdidas por propagación. Conociendo el canal de transmisión se puede solventar el problema de las altas pérdidas. Esta tesis tiene como objetivo caracterizar el canal de radio frecuencia (RF) para la nueva generación de dispositivos médicos implantables. Para caracterizar el canal se han empleado tres diferentes metodologías: simulaciones numéricas, medidas en phantom y experimentos en animales vivos. Las medidas en phantom fueron realizadas en un nuevo sistema de medidas expresamente disen¿ados para medidas de dentro a fuera del cuerpo humano en la banda de frecuencias UWB. Además, se utilizó un novedoso recipiente con dos capas de phantom imitando la zona gastrointestinal del cuerpo. Estos phantoms fueron creados para este tipo de medidas y son extremadamente precisos a las frecuencias UWB. Para los experimentos en animales se utilizaron cerdos y se intentó reproducir en ellos las medidas previamente realizadas en phantom. Las simulaciones software se realizaron con la intención de replicar ambas metodologías. Una vez realizados los experimentos se realizó un extensivo estudio del canal en dominio frecuencial y temporal. Mas en detalle, se compararon las antenas usadas en la recepción y transmisión, el efecto de la grasa en el canal, la formas del recipiente contenedor de phantom y las componentesmulticamino. Como resultado se ha propuesto un modelo de propagación del canal para la banda baja de las frecuencias UWB (3.1 -5.1 GHz) para la zona gastrointestinal del cuerpo humano. Este modelo de propagación ha sido validado utilizando las tres metodologías previamente descritas y comparada con otros estudios existentes en literatura. Finalmente, se midió el canal de propagación para una determinada aplicación a bajas frecuencias con señales UWB. También se realizaron medidas del canal de propagación en la zona cardíaca del cuerpo humano desde un punto de vista de seguridad de datos. Los resultados obtenidos en esta tesis confirman los beneficios que tendría la utilización de frecuencias UWB para las futuras generaciones de dispositivos médicos implantables.[CA] La població mundial a països desenvolupats està envellint-se i enfrontant-se a un augment d'infermetats principalment causades per la edat. Les noves tecnologies mèdiques poden ajudar a detectar, diagnosticar i tractar aquestes malalties, estalviant diners, temps i recursos sanitaris. Els dispositius implantables sense fils han generat un nou panorama per a les noves generacions de dispositius mèdics. Les freqüències com la banda de UWB estan sent considerades per a les futures tecnologies implantables. La reduïda grandària de les antenes, la baixa potència de transmissió i les altes velocitats de dades son característiques buscades per als dispositius implantables. Per contra, els éssers humans depenen de la freqüència en el sentit que a majors freqüències, majors les pèrdues per propagació quan el senyal travessa el cos humà d'interior a exterior. Per solventar aquestes pèrdues el canal de propagació s'ha d'entendre i conèixer de la millor manera possible. Aquesta tesi doctoral te com a objectiu caracteritzar el canal de radio freqüència (RF) per a la nova generació de dispositius mèdics implantables. S'han emprat tres metodologies diferents per a realitzar aquesta caracterització: simulacions software, mesures amb fantomes i experiments amb animals vius. Els experiments amb fantomes es van realitzar a un sistema de mesures dissenyat expressament per a les transmissions de dins a fora del cos humà a les freqüències UWB. També es van utilitzar un contenidor per als fantomes de dues capes, imitant l'area gastrointestinal dels humans. Per als experiments a animals es van emprar porcs, replicant els experiments al laboratori en fantomes de la forma més semblant possible. Les simulacions software foren dissenyades per a imitar les experiments amb fantomes i animals. Després dels experiments el canal de propagació es va investigar exhaustivament des del domini freqüèncial i temporal. S'ha observat com les antenes en transmissió i recepció afecten al senyal, la influència de la grassa, la forma del contenidor de fantoma i les possibles contribucions multicamí. Finalment es proposa un nou model de propagació per a les baixes freqüències UWB (3.1 a 5.1 GHz) per a la zona GI del cos humà. El model es va validar utilitzant les tres metodologies abans esmentades i també foren comparades amb model ja existents a la literature. Finalment des d'un punt de vista aplicat, el canal es va avaluar per al senyal UWB a baixes freqüències (60 MHz). A més a més, per a la nova generació de marcapassos sense fil es va investigar el canal des d'un punt de vista de seguretat de dades. Els resultats obtinguts a aquesta tesi confirmen els avantatges d'emprar la banda de freqüències UWB per a la nova generació de dispositius médics implantables.[EN] The current global population in developed countries is becoming older and facing an increase in diseases mainly caused by age. New medical technologies can help to detect, diagnose and treat illness, saving money, time, and resources of physicians. Wireless in-body devices opened a new scenario for the next generation of medical devices. Frequencies like the Ultra Wide-band (UWB) frequency band (3.1 - 10.6 GHz) are being considered for the next generation of in-body wireless devices. The small size of the antennas, the low power transmission, and the higher data rate are desirable characteristics for in-body devices. However, the human body is frequency ependent, which means higher losses of the radio frequency (RF) signal from in- to out-side the body as the frequency increases. To overcome this, the propagation channel has to be understood and known as much possible to process the signal accordingly. This dissertation aims to characterize the (RF) channel for the future of in-body medical devices. Three different methodologies have been used to characterize the channel: numerical simulations, phantom measurements, and living animals experiments. The phantom measurements were performed in a novel testbed designed for the purpose of in-body measurements at the UWB frequency band. Moreover, multi-layer high accurate phantoms mimicking the gastrointesintal (GI) area were employed. The animal experiments were conducted in living pigs, replicating in the fairest way as possible the phantom measurement campaigns. Lastly, the software simulations were designed to replicate the experimental measurements. An in-depth and detail analysis of the channel was performed in both, frequency and time domain. Concretely, the performance of the receiving and transmitting antennas, the effect of the fat, the shape of the phantom container, and the multipath components were evaluated. Finally, a novel path loss model was obtained for the low UWB frequency band (3.1 - 5.1 GHz) at GI scenarios. The model was validated using the three methodologies and compared with previous models in literature. Finally, from a practical case point of view, the channel was also evaluated for UWB signals at lower frequencies (60 MHz) for the GI area. In addition, for the next generation of leadless pacemakers the security link between the heart and an external device was also evaluated. The results obtained in this dissertation reaffirm the benefits of using the UWB frequency band for the next generation of wireless in-body medical devices.Pérez Simbor, S. (2019). In-body to On-body Experimental UWB Channel Characterization for the Human Gastrointestinal Area [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/133034TESI

Antenna and radio channel characterisation for low‐power personal and body area networks

PhDThe continuous miniaturisation of sensors, as well as the progression in wearable electronics, embedded software, digital signal processing and biomedical technologies, have led to new usercentric networks, where devices can be carried in the user’s pockets, attached to the user’s body. Body-centric wireless communications (BCWCs) is a central point in the development of fourth generation mobile communications. Body-centric wireless networks take their place within the personal area networks, body area networks and sensor networks which are all emerging technologies that have a wide range of applications (such as, healthcare, entertainment, surveillance, emergency, sports and military). The major difference between BCWC and conventional wireless systems is the radio channels over which the communication takes place. The human body is a hostile environment from a radio propagation perspective and it is therefore important to understand and characterise the effects of the human body on the antenna elements, the radio channel parameters and, hence, system performance. This thesis focuses on the study of body-worn antennas and on-body radio propagation channels. The performance parameters of five different narrowband (2.45 GHz) and four UWB (3.1- 10.6 GHz) body-worn antennas in the presence of human body are investigated and compared. This was performed through a combination of numerical simulations and measurement campaigns. Parametric studies and statistical analysis, addressing the human body effects on the performance parameters of different types of narrowband and UWB antennas have been presented. The aim of this study is to understand the human body effects on the antenna parameters and specify the suitable antenna in BCWCs at both 2.45 GHz and UWB frequencies. Extensive experimental investigations are carried out to study the effects of various antenna types on the on-body radio propagation channels as well. Results and analysis emphasize the best body-worn antenna for reliable and power-efficient on-body communications. Based on the results and analysis, a novel dual-band and dual-mode antenna is proposed for power-efficient and reliable on-body and off-body communications. The on-body performance of the DBDM antenna at 2.45 GHz is compared with other five narrowband antennas. Based on the results and analysis of six narrowband and four UWB antennas, antenna specifications and design guidelines are provided that will help in selecting the best body-worn antenna for both narrowband and UWB systems to be applied in body-centric wireless networks (BCWNs). A comparison between IV the narrowband and UWB antenna parameters are also provided. At the end of the thesis, the subject-specificity of the on-body radio propagation channel at 2.45 GHz and 3-10 GHz was experimentally investigated by considering eight real human test subjects of different shapes, heights and sizes. The subject-specificity of the on-body radio propagation channels was compared between the narrowband and UWB systems as well

Antennas for UWB Applications

“Antennas for UWB Applications” chapter deals with an overview of ultrawideband (UWB) antennas used for different applications. Some fundamental and widely used radiators, such as fat monopole, microstrip-fed and coplanar waveguide (CPW)-fed slot antennas, and tapered end-fire antennas are presented. Selected antenna designs are presented in relation to the UWB applications and their dictating radiation and operation principles. The demonstrated UWB antennas include antennas for handheld devices used for personal area network (PAN) communications; antennas for localization and positioning; UWB antennas for radio-frequency identifications (RFIDs); radar antennas for through-wall imaging, for ground-penetrating radar (GPR), and for breast tumor detection; and more generally, UWB antennas used for sensing. For some of the aforementioned applications, UWB antennas with special characteristics are needed, and they are presented and associated with the relevant applications. These include reconfigurable UWB antennas, metamaterial-loaded UWB antennas, and conformal UWB antennas. The usefulness of these special characteristics in comparison with the claimed advantages is critically evaluated. For the UWB applications presented in the chapter, one type or UWB antenna is recommended

UWB radio channel and diversity characterization for wireless implanted devices

Las redes de área corporal permiten la interconexión de nodos independientes situados dentro o fuera de la superficie corporal o, incluso, alejados de dicha superficie. En cuanto a las comunicaciones intracorporales, el establecimiento de un enlace robusto con una cápsula endoscópica o con un marcapasos, son ejemplos de los avances tecnológicos conseguidos en las últimas décadas. A pesar de estos desarrollos en asistencia sanitaria, los estándares actuales para este tipo de comunicaciones no permiten conexiones inalámbricas de alta velocidad de transmisión, las cuales son comunes en los servicios actuales de telecomunicaciones. Los sistemas UWB han surgido como potencial candidato para las futuras redes de comunicaciones inalámbricas intracorporales. No obstante, el principal obstáculo de la tecnología UWB para aplicaciones intracorporales es la alta atenuación que sufren las señales transmitidas al atravesar los distintos tejidos corporales, que aumenta drásticamente con el aumento de la frecuencia. Por tanto, es importante una caracterización precisa del canal UWB intracorporal a la hora de validar dicha banda como la adecuada para este propósito.Esta tesis se centra en el análisis de la tecnología UWB para posibilitar comunicaciones intracorporales inalámbricas desde un punto de vista experimental. Para conseguir este objetivo, se ha empleado un novedoso sistema de medidas experimental basado en fantomas en diversos escenarios de propagación intracorporal. De esta forma, se pueden comprobar las pérdidas de propagación en el medio así como la diversidad del canal de una forma fiable. Con el fin de validar los valores obtenidos en el laboratorio, se han comparado y analizado con los obtenidos en un experimento in vivo. Por otro lado, se han diseñado y fabricado nuevas antenas UWB candidatas para comunicaciones intracorporales, empleando técnicas existentes y nuevas de miniaturización y optimización. Finalmente, se han usado técnicas basadas en diversidad para mejorar el rendimiento del canal de propagación en dos escenarios intracorporales diferentes.Wireless Body Area Networks allow the interconnection between independent nodes located either inside or over the body skin or further. Regarding in-body communications, establishing a proper link with a capsule endoscope or with a pacemaker are examples of technological advances achieved in the last decades. In spite of these healthcare developments, current standards for these kind of communications do not allow high data rate wireless connections, which are common in the current telecommunication services. UWB systems have emerged as a potential solution for future wireless in-body communications. Nevertheless, the main drawback of UWB for in-body applications is the high attenuation of human body tissues which increases dramatically with the increment of frequency. Hence, an accurate UWB in-body channel characterization is relevant in order validate UWB frequency band as the best candidate for future networks of implantable nodes. This thesis is devoted to test UWB technology for in-body communications from an experimental point of view. To achieve this goal, a novel spatial phantom-based measurement setup is used in several in-body propagation scenarios. Thus, the losses in the propagation medium and the channel diversity are checked in a reliable way. In order to check the values obtained in laboratory, they are compared and discussed with those obtained in an in vivo experiment. On the other hand, new UWB antenna candidates for inbody communications are designed and manufactured by using typical and new miniaturization and antenna optimization techniques for this purpose. Finally, diversity-based techniques are used to improve the performance of the propagation channel in two different in-body scenarios.Les xarxes d'àrea corporal permeten la interconnexió de nodes independents situats, o bé dins, o bé sobre la pell, o inclús allunyats del propi cos. Pel que fa a les comunicacions intracorporals, l'establiment d'un bon enllaç amb una càpsula endoscòpica o amb un marcapassos, són exemples dels avanços tecnològics aconseguits les darreres dècades. A pesar d'aquests desenvolupaments en assistència sanitària, els estàndards actuals per a aquests tipus de comunicacions no permeten connexions sense fil d'alta velocitat de transmissió, que són habituals als serveis actuals de telecomunicacions. Els sistemes UWB han sorgit com una solució potencial per a les futures comunicacions sense fill intracorporals. No obstant, el principal obstacle de la tecnologia UWB per a les aplicacions intracorporals és l'alta atenuació dels teixits del cos humà, que augmenta dràsticament amb l'increment de freqüència. Per tant, és important una caracterització acurada del canal UWB intracorporal a l'hora de validar la banda de freqüència UWB com a la millor candidata per a les futures xarxes de nodes implantats.Aquesta tesi se centra en l'anàlisi de la tecnologia UWB per a comunicacions intracorporals des d'un punt de vista experimental. Per a aconseguir aquest objectiu s'ha emprat un sistema novedós de mesures experimentals, basat en fantomes, en diversos escenaris de propagació intracorporal. D'aquesta manera es poden comprovar les pèrdues de propagació en el medi i la diversitat del canal d'una forma fiable. Per tal d'avaluar els valors obtinguts al laboratori, s'han comparat i analitzat amb aquells obtinguts en un experiment in vivo. Per altra banda, s'han dissenyat i fabricat noves antenes UWB candidates per a comunicacions intracorporals emprant tècniques típiques i noves de miniaturització i optimització d'antenes per a aquest propòsit. Finalment s'han usat tècniques basades en diversitat per a millorar el rendiment del canal de propagació en dos escenaris intracorporals diferents.Andreu Estellés, C. (2018). UWB radio channel and diversity characterization for wireless implanted devices [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/111836TESI

Modelling and characterisation of antennas and propagation for body-centric wireless communication

PhDBody-Centric Wireless Communication (BCWC) is a central point in the development of fourth generation mobile communications. The continuous miniaturisation of sensors, in addition to the advancement in wearable electronics, embedded software, digital signal processing and biomedical technologies, have led to a new concept of usercentric networks, where devices can be carried in the user’s pockets, attached to the user’s body or even implanted. Body-centric wireless networks take their place within the personal area networks, body area networks and body sensor networks which are all emerging technologies that have a broad range of applications such as healthcare and personal entertainment. The major difference between BCWC and conventional wireless systems is the radio channel over which the communication takes place. The human body is a hostile environment from radio propagation perspective and it is therefore important to understand and characterise the effect of the human body on the antenna elements, the radio channel parameters and hence the system performance. This is presented and highlighted in the thesis through a combination of experimental and electromagnetic numerical investigations, with a particular emphasis to the numerical analysis based on the finite-difference time-domain technique. The presented research work encapsulates the characteristics of the narrowband (2.4 GHz) and ultra wide-band (3-10 GHz) on-body radio channels with respect to different digital phantoms, body postures, and antenna types hence highlighting the effect of subject-specific modelling, static and dynamic environments and antenna performance on the overall body-centric network. The investigations covered extend further to include in-body communications where the radio channel for telemetry with medical implants is also analysed by considering the effect of different digital phantoms on the radio channel characteristics. The study supports the significance of developing powerful and reliable numerical modelling to be used in conjunction with measurement campaigns for a comprehensive understanding of the radio channel in body-centric wireless communication. It also emphasises the importance of considering subject-specific electromagnetic modelling to provide a reliable prediction of the network performance

Ultra-wideband antennas

The focus of UWB antenna research activity has matured in recent years and currently mainly concentrates on applications such as biomedicine and security. Early UWB antenna designs were driven by the FCC allocation of spectrum in 2002 and focussed on obtaining wide impedance bandwidths with reasonable group delay characteristics. Many of these were simple planar monopoles antennas with canonical geometries. The emergence of new applications channelled the emphasis towards miniaturisation and integration into devices. This required optimisation of the antenna geometries to ensure that good system performance is achieved from the integrated antenna. Many optimisation techniques are available including the spline technique to generate the outline of the antenna element and ground plane. Simple methods based on genetic algorithms are employed and evolutionary algorithms which are capable of optimising for multiple goals are beneficial when multiple antenna parameters are simultaneously investigated. These techniques have proven advantageous especially when time-domain performance is critical and provide solutions for both single-ended and differential feed arrangements. The main applications using UWB channels in the 3.1 GHz −10.6 GHz spectrum are localization and tracking applications, mainly employing impulse radio UWB imaging, and generally using linear polarization. However circularly-polarized UWB antennas have been developed, both directional and omnidirectional and are being investigated across various systems

Wide Band Embedded Slot Antennas for Biomedical, Harsh Environment, and Rescue Applications

For many designers, embedded antenna design is a very challenging task when designing embedded systems. Designing Antennas to given set of specifications is typically tailored to efficiently radiate the energy to free space with a certain radiation pattern and operating frequency range, but its design becomes even harder when embedded in multi-layer environment, being conformal to a surface, or matched to a wide range of loads (environments). In an effort to clarify the design process, we took a closer look at the key considerations for designing an embedded antenna. The design could be geared towards wireless/mobile platforms, wearable antennas, or body area network. Our group at UT has been involved in developing portable and embedded systems for multi-band operation for cell phones or laptops. The design of these antennas addressed single band/narrowband to multiband/wideband operation and provided over 7 bands within the cellular bands (850 MHz to 2 GHz). Typically the challenge is: many applications require ultra wide band operation, or operate at low frequency. Low frequency operation is very challenging if size is a constraint, and there is a need for demonstrating positive antenna gain

High-performance wireless interface for implant-to-air communications

Nous élaborons une interface cerveau-machine (ICM) entièrement sans fil afin de fournir un système de liaison directe entre le cerveau et les périphériques externes, permettant l’enregistrement et la stimulation du cerveau pour une utilisation permanente. Au cours de cette thèse, nous explorons la modélisation de canal, les antennes implantées et portables en tant que propagateurs appropriés pour cette application, la conception du nouveau système d’un émetteur-récepteur UWB implantable, la conception niveau système du circuit et sa mise en oeuvre par un procédé CMOS TSMC 0.18 um. En plus, en collaboration avec Université McGill, nous avons conçu un réseau de seize antennes pour une détection du cancer du sein à l’aide d’hyperfréquences. Notre première contribution calcule la caractérisation de canal de liaison sans fil UWB d’implant à l’air, l’absorption spécifique moyennée (ASAR), et les lignes directrices de la FCC sur la densité spectrale de puissance UWB transmis. La connaissance du comportement du canal est nécessaire pour déterminer la puissance maximale permise à 1) respecter les lignes directrices ANSI pour éviter des dommages aux tissus et 2) respecter les lignes directrices de la FCC sur les transmissions non autorisées. Nous avons recours à un modèle réaliste du canal biologique afin de concevoir les antennes pour l’émetteur implanté et le récepteur externe. Le placement des antennes est examiné avec deux scénarios contrastés ayant des contraintés de puissance. La performance du système au sein des tissus biologiques est examinée par l’intermédiaire des simulations et des expériences. Notre deuxième contribution est dédiée à la conception des antennes simples et à double polarisation pour les systèmes d’enregistrement neural sans fil à bande ultra-large en utilisant un modèle multicouches inhomogène de la tête humaine. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à l’implantation ; nous étudions des matériaux à la fois flexibles et rigides et examinons des compromis de performance. Les antennes proposées sont conçues pour fonctionner dans une plage de fréquence de 2-11 GHz (ayant S11-dessous de -10 dB) couvrant à la fois la bande 2.45 GHz (ISM) et la bande UWB 3.1-10.6 GHz. Des mesures confirment les résultats de simulation et montrent que les antennes flexibles ont peu de dégradation des performances en raison des effets de flexion (en termes de correspondance d’impédance). Finalement, une comparaison est réalisée entre quatre antennes implantables, couvrant la gamme 2-11 GHz : 1) une rigide, à la polarisation simple, 2) une rigide, à double polarisation, 3) une flexible, à simple polarisation et 4) une flexible, à double polarisation. Dans tous les cas une antenne rigide est utilisée à l’extérieur du corps, avec une polarisation appropriée. Plusieurs avantages ont été confirmés pour les antennes à la polarisation double : 1) une taille plus petite, 2) la sensibilité plus faible aux désalignements angulaires, et 3) une plus grande fidélité. Notre troisième contribution fournit la conception niveau système de l’architecture de communication sans fil pour les systèmes implantés qui stimulent simultanément les neurones et enregistrent les réponses de neurones. Cette architecture prend en charge un grand nombre d’électrodes (> 500), fournissant 100 Mb/s pour des signaux de stimulation de liaison descendante, et Gb/s pour les enregistrements de neurones de liaison montante. Nous proposons une architecture d’émetteur-récepteur qui partage une antenne ultra large bande, un émetteur-récepteur simplifié, travaillant en duplex intégral sur les deux bandes, et un nouveau formeur d’impulsions pour la liaison montante du Gb/s soutenant plusieurs formats de modulation. Nous présentons une démonstration expérimentale d’ex vivo de l’architecture en utilisant des composants discrets pour la réalisation les taux Gb/s en liaison montante. Une bonne performance de taux d’erreur de bit sur un canal biologique à 0,5, 1 et 2 Gb/s des débits de données pour la télémétrie de liaison montante (UWB) et 100 Mb/s pour la télémétrie en liaison descendante (bande 2.45 GHz) est atteinte. Notre quatrième contribution présente la conception au niveau du circuit d’un dispositif d’émission en duplex total qui est présentée dans notre troisième contribution. Ce dispositif d’émission en duplex total soutient les applications d’interfaçage neural multimodal et en haute densité (les canaux de stimulant et d’enregistrement) avec des débits de données asymétriques. L’émetteur (TX) et le récepteur (RX) partagent une seule antenne pour réduire la taille de l’implant. Le TX utilise impulse radio ultra-wide band (IR-UWB) basé sur une approche alliant des bords, et le RX utilise un nouveau 2.4 GHz récepteur on-off keying (OOK).Une bonne isolation (> 20 dB) entre le trajet TX et RX est mis en oeuvre 1) par mise en forme des impulsions transmises pour tomber dans le spectre UWB non réglementé (3.1-7 GHz), et 2) par un filtrage espace-efficace du spectre de liaison descendante OOK dans un amplificateur à faible bruit RX. L’émetteur UWB 3.1-7 GHz peut utiliser soit OOK soit la modulation numérique binaire à déplacement de phase (BPSK). Le FDT proposé offre une double bande avec un taux de données de liaison montante de 500 Mbps TX et un taux de données de liaison descendante de 100 Mb/s RX, et il est entièrement en conformité avec les standards TSMC 0.18 um CMOS dans un volume total de 0,8 mm2. Ainsi, la mesure de consommation d’énergie totale en mode full duplex est de 10,4 mW (5 mW à 100 Mb/s pour RX, et de 5,4 mW à 500 Mb/s ou 10,8 PJ / bits pour TX). Notre cinquième contribution est une collaboration avec l’Université McGill dans laquelle nous concevons des antennes simples et à double polarisation pour les systèmes de détection du cancer du sein à l’aide d’hyperfréquences sans fil en utilisant un modèle multi-couche et inhomogène du sein humain. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à des applications portables. Les antennes flexibles miniaturisées monopôles et spirales sur un 50 um Kapton polyimide sont conçus, en utilisant high frequency structure simulator (HFSS), à être en contact avec des tissus biologiques du sein. Les antennes proposées sont conçues pour fonctionner dans une gamme de fréquences de 2 à 4 GHz. Les mesures montrent que les antennes flexibles ont une bonne adaptation d’impédance dans les différentes positions sur le sein. De Plus, deux antennes à bande ultralarge flexibles 4 × 4 (simple et à double polarisation), dans un format similaire à celui d’un soutien-gorge, ont été développés pour un système de détection du cancer du sein basé sur le radar.We are working on a fully wireless brain-machine-interface to provide a communication link between the brain and external devices, enabling recording and stimulating the brain for permanent usage. In this thesis we explore channel modeling, implanted and wearable antennas as suitable propagators for this application, system level design of an implantable UWB transceiver, and circuit level design and implementing it by TSMC 0.18 um CMOS process. Also, in a collaboration project with McGill University, we designed a flexible sixteen antenna array for microwave breast cancer detection. Our first contribution calculates channel characteristics of implant-to-air UWB wireless link, average specific absorption rate (ASAR), and FCC guidelines on transmitted UWB power spectral density. Knowledge of channel behavior is required to determine the maximum allowable power to 1) respect ANSI guidelines for avoiding tissue damage and 2) respect FCC guidelines on unlicensed transmissions. We utilize a realistic model of the biological channel to inform the design of antennas for the implanted transmitter and the external receiver. Antennas placement is examined under two scenarios having contrasting power constraints. Performance of the system within the biological tissues is examined via simulations and experiments. Our second contribution deals with designing single and dual-polarization antennas for wireless ultra-wideband neural recording systems using an inhomogeneous multi-layer model of the human head. Antennas made from flexible materials are more easily adapted to implantation; we investigate both flexible and rigid materials and examine performance trade-offs. The proposed antennas are designed to operate in a frequency range of 2–11 GHz (having S11 below -10 dB) covering both the 2.45 GHz (ISM) band and the 3.1–10.6 GHz UWB band. Measurements confirm simulation results showing flexible antennas have little performance degradation due to bending effects (in terms of impedance matching). Finally, a comparison is made of four implantable antennas covering the 2-11 GHz range: 1) rigid, single polarization, 2) rigid, dual polarization, 3) flexible, single polarization and 4) flexible, dual polarization. In all cases a rigid antenna is used outside the body, with an appropriate polarization. Several advantages were confirmed for dual polarization antennas: 1) smaller size, 2) lower sensitivity to angular misalignments, and 3) higher fidelity. Our third contribution provides system level design of wireless communication architecture for implanted systems that simultaneously stimulate neurons and record neural responses. This architecture supports large numbers of electrodes (> 500), providing 100 Mb/s for the downlink of stimulation signals, and Gb/s for the uplink neural recordings. We propose a transceiver architecture that shares one ultra-wideband antenna, a streamlined transceiver working at full-duplex on both bands, and a novel pulse shaper for the Gb/s uplink supporting several modulation formats. We present an ex-vivo experimental demonstration of the architecture using discrete components achieving Gb/s uplink rates. Good bit error rate performance over a biological channel at 0.5, 1, and 2 Gbps data rates for uplink telemetry (UWB) and 100 Mbps for downlink telemetry (2.45 GHz band) is achieved. Our fourth contribution presents circuit level design of the novel full-duplex transceiver (FDT) which is presented in our third contribution. This full-duplex transceiver supports high-density and multimodal neural interfacing applications (high-channel count stimulating and recording) with asymmetric data rates. The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2.4-GHz on-off keying (OOK) receiver. Proper isolation (> 20 dB) between the TX and RX path is implemented 1) by shaping the transmitted pulses to fall within the unregulated UWB spectrum (3.1-7 GHz), and 2) by spaceefficient filtering (avoiding a circulator or diplexer) of the downlink OOK spectrum in the RX low-noise amplifier. The UWB 3.1-7 GHz transmitter can use either OOK or binary phase shift keying (BPSK) modulation schemes. The proposed FDT provides dual band 500-Mbps TX uplink data rate and 100 Mbps RX downlink data rate, and it is fully integrated into standard TSMC 0.18 um CMOS within a total size of 0.8 mm2. The total measured power consumption is 10.4 mW in full duplex mode (5 mW at 100 Mbps for RX, and 5.4 mW at 500 Mbps or 10.8 pJ/bit for TX). Our fifth contribution is a collaboration project with McGill University which we design single and dual-polarization antennas for wireless ultra-wideband breast cancer detection systems using an inhomogeneous multi-layer model of the human breast. Antennas made from flexible materials are more easily adapted to wearable applications. Miniaturized flexible monopole and spiral antennas on a 50 um Kapton polyimide are designed, using a high frequency structure simulator (HFSS), to be in contact with biological breast tissues. The proposed antennas are designed to operate in a frequency range of 2–4 GHz (with reflection coefficient (S11) below -10 dB). Measurements show that the flexible antennas have good impedance matching while in different positions with different curvature around the breast. Furthermore, two flexible conformal 4×4 ultra-wideband antenna arrays (single and dual polarization), in a format similar to that of a bra, were developed for a radar-based breast cancer detection system

UWB Path Loss Models for Ingestible Devices

[EN] Currently, some medical devices such as the Wireless Capsule Endoscopy (WCE) are used for data transmission from inside to outside the body. Nevertheless, for certain applications such as WCE, the data rates offered by current medical frequency bands can result insufficient. Ultra Wideband (UWB) frequency band has become an interesting solution for this. However, to date, there is not a formal channel path loss model for the UWB frequency band in the gastrointestinal (GI) scenario due to the huge differences between the proposed studies. There are three main methodologies to characterize the propagation channel, software simulations and experimental measurements either in phantom or in in vivo animals. Previous works do not compare all the methodologies or present some disagreements with the literature. In this paper, a dedicated study of the path loss using the three methodologies aforementioned (simulations, phantoms and in vivo measurements) and a comparison with previous researches in the literature is performed. Moreover, numerical values for a path loss model which agrees with the three methodologies and the literature are proposed. This paper aims at being the starting point for a formal path loss model in the UWB frequency band for WBANs in the GI scenarioThis work was supported in part by the European Union's H2020-MSCA-ITN Program for the "Wireless In-body Environment Communication" Project under Grant 675353, in part by the Programa de Ayudas de Investigacion y Desarrollo (PAID-01-16) from Universitat Politecnica de Valencia, and in part by the Ministerio de Economia y Competitividad, Spain under Grant TEC2014-60258-C2-1-R through the European FEDER Funds.Pérez-Simbor, S.; Andreu-Estellés, C.; Garcia-Pardo, C.; Frasson, M.; Cardona Marcet, N. (2019). UWB Path Loss Models for Ingestible Devices. IEEE Transactions on Antennas and Propagation. 67(8):5025-5034. https://doi.org/10.1109/TAP.2019.2891717S5025503467

Flexible, polarization-diverse UWB antennas for implantable neural recording systems

Implanted antennas for implant-to-air data communications must be composed of material compatible with biological tissues. We design single and dual-polarization antennas for wireless ultra-wideband neural recording systems using an inhomogeneous multi-layer model of the human head. Antennas made from flexible materials are more easily adapted to implantation; we investigate both flexible and rigid materials and examine performance trade-offs. The proposed antennas are designed to operate in a frequency range of 2-11 GHz (having S11 below -10 dB) covering both the 2.45 GHz (ISM) band and the 3.1-10.6 GHz UWB band. Measurements confirm simulation results showing flexible antennas have little performance degradation due to bending effects (in terms of impedance matching). Our miniaturized flexible antennas are 12 mm×12 mm and 10 mm×9 mm for single- and dual-polarizations, respectively. Finally, a comparison is made of four implantable antennas covering the 2-11 GHz range: 1) rigid, single polarization, 2) rigid, dual polarization, 3) flexible, single polarization and 4) flexible, dual polarization. In all cases a rigid antenna is used outside the body, with an appropriate polarization. Several advantages were confirmed for dual polarization antennas: 1) smaller size, 2) lower sensitivity to angular misalignments, and 3) higher fidelity