Surface and bulk stresses drive morphological changes in fibrous microtissues

Engineered fibrous tissues consisting of cells encapsulated within collagen gels are widely used three-dimensional in vitro models of morphogenesis and wound healing. Although cell-mediated matrix remodeling that occurs within these scaffolds has been extensively studied, less is known about the mesoscale physical principles governing the dynamics of tissue shape. Here, we show both experimentally and by using computer simulations how surface contraction through the development of surface stresses (analogous to surface tension in fluids) coordinates with bulk contraction to drive shape evolution in constrained three-dimensional microtissues. We used microelectromechanical systems technology to generate arrays of fibrous microtissues and robot-assisted microsurgery to perform local incisions and implantation. We introduce a technique based on phototoxic activation of a small molecule to selectively kill cells in a spatially controlled manner. The model simulations, which reproduced the experimentally observed shape changes after surgical and photochemical operations, indicate that fitting of only bulk and surface contractile moduli is sufficient for the prediction of the equilibrium shape of the microtissues. The computational and experimental methods we have developed provide a general framework to study and predict the morphogenic states of contractile fibrous tissues under external loading at multiple length scales.Published versio

Constructing living buildings: a review of relevant technologies for a novel application of biohybrid robotics

Biohybrid robotics takes an engineering approach to the expansion and exploitation of biological behaviours for application to automated tasks. Here, we identify the construction of living buildings and infrastructure as a high-potential application domain for biohybrid robotics, and review technological advances relevant to its future development. Construction, civil infrastructure maintenance and building occupancy in the last decades have comprised a major portion of economic production, energy consumption and carbon emissions. Integrating biological organisms into automated construction tasks and permanent building components therefore has high potential for impact. Live materials can provide several advantages over standard synthetic construction materials, including self-repair of damage, increase rather than degradation of structural performance over time, resilience to corrosive environments, support of biodiversity, and mitigation of urban heat islands. Here, we review relevant technologies, which are currently disparate. They span robotics, self-organizing systems, artificial life, construction automation, structural engineering, architecture, bioengineering, biomaterials, and molecular and cellular biology. In these disciplines, developments relevant to biohybrid construction and living buildings are in the early stages, and typically are not exchanged between disciplines. We, therefore, consider this review useful to the future development of biohybrid engineering for this highly interdisciplinary application.publishe

Integration of aerial and terrestrial locomotion modes in a bioinspired robotic system

In robotics, locomotion is a fundamental task for the development of high-level activities such as navigation. For a robotic system, the challenge of evading environmental obstacles depends both on its physical capabilities and on the strategies followed to achieve it. Thus, a robot with the ability to develop several modes of locomotion (walking, flying or swimming) has a greater probability of success in achieving its goal than a robot that develops only one. In nature, Hymenoptera insects use terrestrial and aerial modes of locomotion to carry out their activities. Mimicry the physical capabilities of these insects opens the possibility of improvements in the area of robotic locomotion. Therefore, this work seeks to generate a bio-inspired robotic system that integrates the terrestrial and aerial modes of locomotion. The methodology used in this research project has considered the anatomical study and characterization of Hymenoptera insects locomotion, the proposal of conceptual models that integrate terrestrial and aerial modes locomotion, the construction of a physical platform and experimental testing of the system. In addition, a gait generation approach based on an artificial nervous system of coupled nonlinear oscillators has been proposed. This approach has resulted in the generation of a coherent and functional gait pattern that, in combination with the flight capabilities of the system, has constituted an aero-terrestrial robot. The results obtained in this work include the construction of a bioinspired physical platform, the generation of the gait process using an artificial nervous system and the experimental tests on the integration of aero-terrestrial locomotion.Conacyt - Becario Naciona

Polymer capsules as building blocks for soft, connected mesostructures

We show that polymer capsules can serve as soft building blocks for creating a range of mesoscale (0.1 to 10 mm) structures. The central innovation is a new approach for connecting spherical capsules by exploiting electrostatic complexation. Using this approach, connected structures with complex shapes can be easily assembled, and more importantly, a single connected structure can be made to have a diverse array of functions. The modular approach to shape and function is very much like using Lego bricks of different colors. The connected structures can be made responsive (capable of being actuated) by magnetic fields by including magnetic capsules within them. One motivation for creating these structures is to mimic the mechanics and motility of small creatures such as the earthworm or ant - this could eventually enable the design of autonomous biomimetic robots. In addition, soft connected structures could be employed to transport cargo such as drugs or proteins in blood vessels, or to construct valves, rotors, or mixers in microfluidic or lab-on-a-chip devices

The coming decade of digital brain research - A vision for neuroscience at the intersection of technology and computing

Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are: To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals. To provide a scientific framework for current and future development of EBRAINS. To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research. To identify and address key ethical and societal issues. While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience

DESIGN OF THREE FINGER GRIPPER WITH FSR

Technological advancement is widening up by the advent of new inventions. Robots are going to be an integral part of the completely automated industries. There are many instances where profile detection. In this paper, discussed about the three finger gripper has the abilities with this dexterous electric gripper. Three fingers gripper is extreme changeability and fixable gripping control. Its finger has several positions of geometrics and dimensions. Its specific control of crossing point allows orthodox forward motion on the finger location, rapidity and force. These fingers design in CREO 3.0 software and produced by RPT. Fingers are evaluated to check if the finger is flexible motion. The force is measured by a force sensitive resister (FSR). A force sensor is measure a grasping object whose confrontation difference between before and after force is applied. The Arduino mega controller is used for controlling the servo motor and FSR in gripping motion. This servo motor is 180Ëšrotation angle, Control loop response mechanism is extensively used for accurate control. The Controlled gripper finger is sensed and gripped with force which is being analyzed in the data