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Adverse Drug Reaction Classification With Deep Neural Networks
We study the problem of detecting sentences describing adverse drug reactions (ADRs) and frame the problem as binary classification. We investigate different neural network (NN) architectures for ADR classification. In particular, we propose two new neural network models, Convolutional Recurrent Neural Network (CRNN) by concatenating convolutional neural networks with recurrent neural networks, and Convolutional Neural Network with Attention (CNNA) by adding attention weights into convolutional neural networks. We evaluate various NN architectures on a Twitter dataset containing informal language and an Adverse Drug Effects (ADE) dataset constructed by sampling from MEDLINE case reports. Experimental results show that all the NN architectures outperform the traditional maximum entropy classifiers trained from n-grams with different weighting strategies considerably on both datasets. On the Twitter dataset, all the NN architectures perform similarly. But on the ADE dataset, CNN performs better than other more complex CNN variants. Nevertheless, CNNA allows the visualisation of attention weights of words when making classification decisions and hence is more appropriate for the extraction of word subsequences describing ADRs
Social media mining for identification and exploration of health-related information from pregnant women
Widespread use of social media has led to the generation of substantial
amounts of information about individuals, including health-related information.
Social media provides the opportunity to study health-related information about
selected population groups who may be of interest for a particular study. In
this paper, we explore the possibility of utilizing social media to perform
targeted data collection and analysis from a particular population group --
pregnant women. We hypothesize that we can use social media to identify cohorts
of pregnant women and follow them over time to analyze crucial health-related
information. To identify potentially pregnant women, we employ simple
rule-based searches that attempt to detect pregnancy announcements with
moderate precision. To further filter out false positives and noise, we employ
a supervised classifier using a small number of hand-annotated data. We then
collect their posts over time to create longitudinal health timelines and
attempt to divide the timelines into different pregnancy trimesters. Finally,
we assess the usefulness of the timelines by performing a preliminary analysis
to estimate drug intake patterns of our cohort at different trimesters. Our
rule-based cohort identification technique collected 53,820 users over thirty
months from Twitter. Our pregnancy announcement classification technique
achieved an F-measure of 0.81 for the pregnancy class, resulting in 34,895 user
timelines. Analysis of the timelines revealed that pertinent health-related
information, such as drug-intake and adverse reactions can be mined from the
data. Our approach to using user timelines in this fashion has produced very
encouraging results and can be employed for other important tasks where
cohorts, for which health-related information may not be available from other
sources, are required to be followed over time to derive population-based
estimates.Comment: 9 page
Effective Feature Representation for Clinical Text Concept Extraction
Crucial information about the practice of healthcare is recorded only in
free-form text, which creates an enormous opportunity for high-impact NLP.
However, annotated healthcare datasets tend to be small and expensive to
obtain, which raises the question of how to make maximally efficient uses of
the available data. To this end, we develop an LSTM-CRF model for combining
unsupervised word representations and hand-built feature representations
derived from publicly available healthcare ontologies. We show that this
combined model yields superior performance on five datasets of diverse kinds of
healthcare text (clinical, social, scientific, commercial). Each involves the
labeling of complex, multi-word spans that pick out different healthcare
concepts. We also introduce a new labeled dataset for identifying the treatment
relations between drugs and diseases
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