Cancer diagnosis using deep learning: A bibliographic review

In this paper, we first describe the basics of the field of cancer diagnosis, which includes steps of cancer diagnosis followed by the typical classification methods used by doctors, providing a historical idea of cancer classification techniques to the readers. These methods include Asymmetry, Border, Color and Diameter (ABCD) method, seven-point detection method, Menzies method, and pattern analysis. They are used regularly by doctors for cancer diagnosis, although they are not considered very efficient for obtaining better performance. Moreover, considering all types of audience, the basic evaluation criteria are also discussed. The criteria include the receiver operating characteristic curve (ROC curve), Area under the ROC curve (AUC), F1 score, accuracy, specificity, sensitivity, precision, dice-coefficient, average accuracy, and Jaccard index. Previously used methods are considered inefficient, asking for better and smarter methods for cancer diagnosis. Artificial intelligence and cancer diagnosis are gaining attention as a way to define better diagnostic tools. In particular, deep neural networks can be successfully used for intelligent image analysis. The basic framework of how this machine learning works on medical imaging is provided in this study, i.e., pre-processing, image segmentation and post-processing. The second part of this manuscript describes the different deep learning techniques, such as convolutional neural networks (CNNs), generative adversarial models (GANs), deep autoencoders (DANs), restricted Boltzmann’s machine (RBM), stacked autoencoders (SAE), convolutional autoencoders (CAE), recurrent neural networks (RNNs), long short-term memory (LTSM), multi-scale convolutional neural network (M-CNN), multi-instance learning convolutional neural network (MIL-CNN). For each technique, we provide Python codes, to allow interested readers to experiment with the cited algorithms on their own diagnostic problems. The third part of this manuscript compiles the successfully applied deep learning models for different types of cancers. Considering the length of the manuscript, we restrict ourselves to the discussion of breast cancer, lung cancer, brain cancer, and skin cancer. The purpose of this bibliographic review is to provide researchers opting to work in implementing deep learning and artificial neural networks for cancer diagnosis a knowledge from scratch of the state-of-the-art achievements

Towards End-to-End Acoustic Localization using Deep Learning: from Audio Signal to Source Position Coordinates

This paper presents a novel approach for indoor acoustic source localization using microphone arrays and based on a Convolutional Neural Network (CNN). The proposed solution is, to the best of our knowledge, the first published work in which the CNN is designed to directly estimate the three dimensional position of an acoustic source, using the raw audio signal as the input information avoiding the use of hand crafted audio features. Given the limited amount of available localization data, we propose in this paper a training strategy based on two steps. We first train our network using semi-synthetic data, generated from close talk speech recordings, and where we simulate the time delays and distortion suffered in the signal that propagates from the source to the array of microphones. We then fine tune this network using a small amount of real data. Our experimental results show that this strategy is able to produce networks that significantly improve existing localization methods based on \textit{SRP-PHAT} strategies. In addition, our experiments show that our CNN method exhibits better resistance against varying gender of the speaker and different window sizes compared with the other methods.Comment: 18 pages, 3 figures, 8 table

Listening for Sirens: Locating and Classifying Acoustic Alarms in City Scenes

This paper is about alerting acoustic event detection and sound source localisation in an urban scenario. Specifically, we are interested in spotting the presence of horns, and sirens of emergency vehicles. In order to obtain a reliable system able to operate robustly despite the presence of traffic noise, which can be copious, unstructured and unpredictable, we propose to treat the spectrograms of incoming stereo signals as images, and apply semantic segmentation, based on a Unet architecture, to extract the target sound from the background noise. In a multi-task learning scheme, together with signal denoising, we perform acoustic event classification to identify the nature of the alerting sound. Lastly, we use the denoised signals to localise the acoustic source on the horizon plane, by regressing the direction of arrival of the sound through a CNN architecture. Our experimental evaluation shows an average classification rate of 94%, and a median absolute error on the localisation of 7.5{\deg} when operating on audio frames of 0.5s, and of 2.5{\deg} when operating on frames of 2.5s. The system offers excellent performance in particularly challenging scenarios, where the noise level is remarkably high.Comment: 6 pages, 9 figure

Sound Event Localization, Detection, and Tracking by Deep Neural Networks

In this thesis, we present novel sound representations and classification methods for the task of sound event localization, detection, and tracking (SELDT). The human auditory system has evolved to localize multiple sound events, recognize and further track their motion individually in an acoustic environment. This ability of humans makes them context-aware and enables them to interact with their surroundings naturally. Developing similar methods for machines will provide an automatic description of social and human activities around them and enable machines to be context-aware similar to humans. Such methods can be employed to assist the hearing impaired to visualize sounds, for robot navigation, and to monitor biodiversity, the home, and cities. A real-life acoustic scene is complex in nature, with multiple sound events that are temporally and spatially overlapping, including stationary and moving events with varying angular velocities. Additionally, each individual sound event class, for example, a car horn can have a lot of variabilities, i.e., different cars have different horns, and within the same model of the car, the duration and the temporal structure of the horn sound is driver dependent. Performing SELDT in such overlapping and dynamic sound scenes while being robust is challenging for machines. Hence we propose to investigate the SELDT task in this thesis and use a data-driven approach using deep neural networks (DNNs). The sound event detection (SED) task requires the detection of onset and offset time for individual sound events and their corresponding labels. In this regard, we propose to use spatial and perceptual features extracted from multichannel audio for SED using two different DNNs, recurrent neural networks (RNNs) and convolutional recurrent neural networks (CRNNs). We show that using multichannel audio features improves the SED performance for overlapping sound events in comparison to traditional single-channel audio features. The proposed novel features and methods produced state-of-the-art performance for the real-life SED task and won the IEEE AASP DCASE challenge consecutively in 2016 and 2017. Sound event localization is the task of spatially locating the position of individual sound events. Traditionally, this has been approached using parametric methods. In this thesis, we propose a CRNN for detecting the azimuth and elevation angles of multiple temporally overlapping sound events. This is the first DNN-based method performing localization in complete azimuth and elevation space. In comparison to parametric methods which require the information of the number of active sources, the proposed method learns this information directly from the input data and estimates their respective spatial locations. Further, the proposed CRNN is shown to be more robust than parametric methods in reverberant scenarios. Finally, the detection and localization tasks are performed jointly using a CRNN. This method additionally tracks the spatial location with time, thus producing the SELDT results. This is the first DNN-based SELDT method and is shown to perform equally with stand-alone baselines for SED, localization, and tracking. The proposed SELDT method is evaluated on nine datasets that represent anechoic and reverberant sound scenes, stationary and moving sources with varying velocities, a different number of overlapping sound events and different microphone array formats. The results show that the SELDT method can track multiple overlapping sound events that are both spatially stationary and moving