2 research outputs found
Describing the orthology signal in a PPI network at a functional, complex level
In recent work, stable evolutionary signal induced by orthologous proteins has
been observed in a Yeast protein-protein interaction (PPI) network. This finding suggests
more connected subgraphs of a PPI network to be potential mediators of evolutionary information.
Because protein complexes are also likely to be present in such subgraphs, it is
interesting to characterize the bias of the orthology signal on the detection of putative protein
complexes. To this aim, we propose a novel methodology for quantifying the functionality of
the orthology signal in a PPI network at a protein complex level. The methodology performs
a differential analysis between the functions of those complexes detected by clustering a PPI
network using only proteins with orthologs in another given species, and the functions of
complexes detected using the entire network or sub-networks generated by random sampling
of proteins. We applied the proposed methodology to a Yeast PPI network using orthology
information from a number of different organisms. The results indicated that the proposed
method is capable to isolate functional categories that can be clearly attributed to the presence
of an evolutionary (orthology) signal and quantify their distribution at a fine-grained
protein level
Describing the Orthology Signal in a PPI Network at a Functional, Complex Level
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