157,156 research outputs found

    Direction-Dependent Polarised Primary Beams in Wide-Field Synthesis Imaging

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    The process of wide-field synthesis imaging is explored, with the aim of understanding the implications of variable, polarised primary beams for forthcoming Epoch of Reionisation experiments. These experiments seek to detect weak signatures from redshifted 21cm emission in deep residual datasets, after suppression and subtraction of foreground emission. Many subtraction algorithms benefit from low side-lobes and polarisation leakage at the outset, and both of these are intimately linked to how the polarised primary beams are handled. Building on previous contributions from a number of authors, in which direction-dependent corrections are incorporated into visibility gridding kernels, we consider the special characteristics of arrays of fixed dipole antennas operating around 100-200 MHz, looking towards instruments such as the Square Kilometre Array (SKA) and the Hydrogen Epoch of Reionization Arrays (HERA). We show that integrating snapshots in the image domain can help to produce compact gridding kernels, and also reduce the need to make complicated polarised leakage corrections during gridding. We also investigate an alternative form for the gridding kernel that can suppress variations in the direction-dependent weighting of gridded visibilities by 10s of dB, while maintaining compact support.Comment: 15 pages, 4 figures. Accepted for publication in JA

    Universal Algorithm for Simulating and Evaluating Cyclic Voltammetry at Macroporous Electrodes by Considering Random Arrays of Microelectrodes

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    An algorithm for the simulation and evaluation of cyclic voltammetry (CV) at macroporous electrodes such as felts, foams, and layered structures is presented. By considering 1D, 2D, and 3D arrays of electrode sheets, cylindrical microelectrodes, hollow‐cylindrical microelectrodes, and hollowspherical microelectrodes the internal diffusion domains of the macroporous structures are approximated. A universal algorithm providing the timedependent surface concentrations of the electrochemically active species, required for simulating cyclic voltammetry responses of the individual planar, cylindrical, and spherical microelectrodes, is presented as well. An essential ingredient of the algorithm, which is based on Laplace integral transformation techniques, is the use of a modified Talbot contour for the inverse Laplace transformation. It is demonstrated that first‐order homogeneous chemical kinetics preceding and/or following the electrochemical reaction and electrochemically active species with non‐equal diffusion coefficients can be included in all diffusion models as well. The proposed theory is supported by experimental data acquired for a reference reaction, the oxidation of [Fe(CN)6]4− at platinum electrodes as well as for a technically relevant reaction, the oxidation of VO2+ at carbon felt electrodes. Based on our calculation strategy, we provide a powerful open source tool for simulating and evaluating CV data implemented into a Python graphical user interface (GUI)

    Can Zipf's law be adapted to normalize microarrays?

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    BACKGROUND: Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for varying organisms and tissues have shown that the majority of expressed genes exhibit a power-law distribution with an exponent close to -1 (i.e. obey Zipf's law). Based on the observation that our single channel and two channel microarray data sets also followed a power-law distribution, we were motivated to develop a normalization method based on this law, and examine how it compares with existing published techniques. A computationally simple and intuitively appealing technique based on this observation is presented. RESULTS: Using pairwise comparisons using MA plots (log ratio vs. log intensity), we compared this novel method to previously published normalization techniques, namely global normalization to the mean, the quantile method, and a variation on the loess normalization method designed specifically for boutique microarrays. Results indicated that, for single channel microarrays, the quantile method was superior with regard to eliminating intensity-dependent effects (banana curves), but Zipf's law normalization does minimize this effect by rotating the data distribution such that the maximal number of data points lie on the zero of the log ratio axis. For two channel boutique microarrays, the Zipf's law normalizations performed as well as, or better than existing techniques. CONCLUSION: Zipf's law normalization is a useful tool where the Quantile method cannot be applied, as is the case with microarrays containing functionally specific gene sets (boutique arrays)
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