A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201

Vec2SPARQL:integrating SPARQL queries and knowledge graph embeddings

<div>Recent developments in machine learning have led to a rise of large</div><div>number of methods for extracting features from structured data. The features</div><div>are represented as vectors and may encode for some semantic aspects of data.</div><div>They can be used in a machine learning models for different tasks or to com-</div><div>pute similarities between the entities of the data. SPARQL is a query language</div><div>for structured data originally developed for querying Resource Description Frame-</div><div>work (RDF) data. It has been in use for over a decade as a standardized NoSQL</div><div>query language. Many different tools have been developed to enable data shar-</div><div>ing with SPARQL. For example, SPARQL endpoints make your data interopera-</div><div>ble and available to the world. SPARQL queries can be executed across multi-</div><div>ple endpoints. We have developed a Vec2SPARQL, which is a general frame-</div><div>work for integrating structured data and their vector space representations.</div><div>Vec2SPARQL allows jointly querying vector functions such as computing sim-</div><div>ilarities (cosine, correlations) or classifications with machine learning models</div><div>within a single SPARQL query. We demonstrate applications of our approach</div><div>for biomedical and clinical use cases. Our source code is freely available at</div><div>https://github.com/bio-ontology-research-group/vec2sparql and we make a</div><div>Vec2SPARQL endpoint available at http://sparql.bio2vec.net/</div

Advances in knowledge discovery and data mining Part II

19th Pacific-Asia Conference, PAKDD 2015, Ho Chi Minh City, Vietnam, May 19-22, 2015, Proceedings, Part II</p

Precision Monitoring for Disease Progression in Patients with Multiple Sclerosis: A Deep Learning Approach

Artificial intelligence has tremendous potential in a range of clinical applications. Leveraging recent advances in deep learning, the works in this thesis has generated a range of technologies for patients with Multiple Sclerosis (MS) that facilitate precision monitoring using routine MRI and clinical assessments; and contribute to realising the goal of personalised disease management. MS is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterised by focal demyelinating plaques in the brain and spinal cord; and progressive neurodegeneration. Despite success in cohort studies and clinical trials, the measurement of disease activity using conventional imaging biomarkers in real-world clinical practice is limited to qualitative assessment of lesion activity, which is time consuming and prone to human error. Quantitative measures, such as T2 lesion load, volumetric assessment of lesion activity and brain atrophy, are constrained by challenges associated with handling real-world data variances. In this thesis, DeepBVC was developed for robust brain atrophy assessment through imaging synthesis, while a lesion segmentation model was developed using a novel federated learning framework, Fed-CoT, to leverage large data collaborations. With existing quantitative brain structural analyses, this work has developed an effective deep learning analysis pipeline, which delivers a fully automated suite of MS-specific clinical imaging biomarkers to facilitate the precision monitoring of patients with MS and response to disease modifying therapy. The framework for individualised MRI-guided management in this thesis was complemented by a disease prognosis model, based on a Large Language Model, providing insights into the risks of clinical worsening over the subsequent 3 years. The value and performance of the MS biomarkers in this thesis are underpinned by extensive validation in real-world, multi-centre data from more than 1030 patients