45 research outputs found
Weakly-supervised localization of diabetic retinopathy lesions in retinal fundus images
Convolutional neural networks (CNNs) show impressive performance for image
classification and detection, extending heavily to the medical image domain.
Nevertheless, medical experts are sceptical in these predictions as the
nonlinear multilayer structure resulting in a classification outcome is not
directly graspable. Recently, approaches have been shown which help the user to
understand the discriminative regions within an image which are decisive for
the CNN to conclude to a certain class. Although these approaches could help to
build trust in the CNNs predictions, they are only slightly shown to work with
medical image data which often poses a challenge as the decision for a class
relies on different lesion areas scattered around the entire image. Using the
DiaretDB1 dataset, we show that on retina images different lesion areas
fundamental for diabetic retinopathy are detected on an image level with high
accuracy, comparable or exceeding supervised methods. On lesion level, we
achieve few false positives with high sensitivity, though, the network is
solely trained on image-level labels which do not include information about
existing lesions. Classifying between diseased and healthy images, we achieve
an AUC of 0.954 on the DiaretDB1.Comment: Accepted in Proc. IEEE International Conference on Image Processing
(ICIP), 201
Combining Fine- and Coarse-Grained Classifiers for Diabetic Retinopathy Detection
Visual artefacts of early diabetic retinopathy in retinal fundus images are
usually small in size, inconspicuous, and scattered all over retina. Detecting
diabetic retinopathy requires physicians to look at the whole image and fixate
on some specific regions to locate potential biomarkers of the disease.
Therefore, getting inspiration from ophthalmologist, we propose to combine
coarse-grained classifiers that detect discriminating features from the whole
images, with a recent breed of fine-grained classifiers that discover and pay
particular attention to pathologically significant regions. To evaluate the
performance of this proposed ensemble, we used publicly available EyePACS and
Messidor datasets. Extensive experimentation for binary, ternary and quaternary
classification shows that this ensemble largely outperforms individual image
classifiers as well as most of the published works in most training setups for
diabetic retinopathy detection. Furthermore, the performance of fine-grained
classifiers is found notably superior than coarse-grained image classifiers
encouraging the development of task-oriented fine-grained classifiers modelled
after specialist ophthalmologists.Comment: Pages 12, Figures
Improving Lesion Segmentation for Diabetic Retinopathy using Adversarial Learning
Diabetic Retinopathy (DR) is a leading cause of blindness in working age
adults. DR lesions can be challenging to identify in fundus images, and
automatic DR detection systems can offer strong clinical value. Of the publicly
available labeled datasets for DR, the Indian Diabetic Retinopathy Image
Dataset (IDRiD) presents retinal fundus images with pixel-level annotations of
four distinct lesions: microaneurysms, hemorrhages, soft exudates and hard
exudates. We utilize the HEDNet edge detector to solve a semantic segmentation
task on this dataset, and then propose an end-to-end system for pixel-level
segmentation of DR lesions by incorporating HEDNet into a Conditional
Generative Adversarial Network (cGAN). We design a loss function that adds
adversarial loss to segmentation loss. Our experiments show that the addition
of the adversarial loss improves the lesion segmentation performance over the
baseline.Comment: Accepted to International Conference on Image Analysis and
Recognition, ICIAR 2019. Published at
https://doi.org/10.1007/978-3-030-27272-2_29 Code:
https://github.com/zoujx96/DR-segmentatio
Experimenting Diabetic Retinopathy Classification Using Retinal Images
Along with many complications, diabetic patients have a high chance to suffer from critical level vision loss and in worst case permanent blindness due to Diabetic Retinopathy (DR). Detecting DR in the early stages is a challenge, since it has no visual indication of this disease in its preliminary stage, thus becomes an important task to accomplish in the health sector. Currently, there have been many proposed DR classifier models but there is a lot of room to improve in terms of efficiency and accuracy. Despite having strong computational power, current deep learning algorithm is not able to gain the trust of the medical experts in classifying DR. In this work, we investigate the possibility of classifying DR using deep learning with Convolutional Neural Network (CNN). We implement preprocessing combined with InceptionV3 and VGG16 models. Experimental results show that InceptionV3 outperforms VGG16. InceptionV3 model achieves an average training accuracy of 73.5 % with a validation accuracy of 68.7%. VGG16 model achieves an average training accuracy of 66.4% with a validation accuracy of 63.13%. The highest training accuracy for InceptionV3 and VGG16 is 79% and 81.2%, respectively. Overall, we achieve an accuracy of 66.6% on 52 images from 3 different classes
Automated Smartphone based System for Diagnosis of Diabetic Retinopathy
Early diagnosis of diabetic retinopathy for treatment of the disease has been
failing to reach diabetic people living in rural areas. Shortage of trained
ophthalmologists, limited availability of healthcare centers, and expensiveness
of diagnostic equipment are among the reasons. Although many deep
learning-based automatic diagnosis of diabetic retinopathy techniques have been
implemented in the literature, these methods still fail to provide a
point-of-care diagnosis. This raises the need for an independent diagnostic of
diabetic retinopathy that can be used by a non-expert. Recently the usage of
smartphones has been increasing across the world. Automated diagnoses of
diabetic retinopathy can be deployed on smartphones in order to provide an
instant diagnosis to diabetic people residing in remote areas. In this paper,
inception based convolutional neural network and binary decision tree-based
ensemble of classifiers have been proposed and implemented to detect and
classify diabetic retinopathy. The proposed method was further imported into a
smartphone application for mobile-based classification, which provides an
offline and automatic system for diagnosis of diabetic retinopathy.Comment: 12 pages, 4 figures, 4 tables, 1 appendix. Copyright \copyright 2019,
IEEE. Published in: 2019 International Conference on Computing,
Communication, and Intelligent Systems (ICCCIS
A Review on Detection of Diabetic Retinopathy using Deep Learning and Transfer Learning based Strategies
Diabetic Retinopathy (DR) is considered to be one of the most widely observed and a complex variation of diabetes and stands as a leading cause of blindness globally. The occurrence of DR causes impairment in the retinal blood vessels and leads to unusual growth of blood arteries in the eye. Manual examinations and analysis suggests that the prevalence of DR has been enormously growing at an exponential rate and has already registered for more than 160 million cases worldwide. On the other hand, its diagnostic screening is not only challenging, but also computationally expensive at the same time. Due to the highlighting importance of its early diagnosis in terms of treatment, multiple concepts to DR detection have been used in the past few years. However, research in recent times has resulted in the fact that deep learning based CNN structures and Transfer Learning based MedNets have been popularly used in DR detection, due to its superior performance in the medical domain. As a result of such advancements in Deep Learning methodologies, this article proposes a review on automated approaches used to detect diabetic retinopathy using image processing and disease classification techniques. The review is further preceded with a comprehensive analysis on training a model with an already pre-trained network whose primary goal is to generate useful information and provide it to diabetic researchers, medical practitioners and patients