Diversity-Multiplexing Tradeoffs in MIMO Relay Channels

A multi-hop relay channel with multiple antenna terminals in a quasi-static slow fading environment is considered. For both full-duplex and half-duplex relays the fundamental diversity-multiplexing tradeoff (DMT) is analyzed. It is shown that, while decode-and-forward (DF) relaying achieves the optimal DMT in the full-duplex relay scenario, the dynamic decode-and-forward (DDF) protocol is needed to achieve the optimal DMT if the relay is constrained to half-duplex operation. For the latter case, static protocols are considered as well, and the corresponding achievable DMT performance is characterized.Comment: To appear at IEEE Global Communications Conf. (Globecom), New Orleans, LA, Nov. 200

Discrete Multitone Modulation for Maximizing Transmission Rate in Step-Index Plastic Optical Fibres

The use of standard 1-mm core-diameter step-index plastic optical fiber (SI-POF) has so far been mainly limited to distances of up to 100 m and bit-rates in the order of 100 Mbit/s. By use of digital signal processing, transmission performance of such optical links can be improved. Among the different technical solutions proposed, a promising one is based on the use of discrete multitone (DMT) modulation, directly applied to intensity-modulated, direct detection (IM/DD) SI-POF links. This paper presents an overview of DMT over SI-POF and demonstrates how DMT can be used to improve transmission rate in such IM/DD systems. The achievable capacity of an SI-POF channel is first analyzed theoretically and then validated by experimental results. Additionally, first experimental demonstrations of a real-time DMT over SI-POF system are presented and discusse

Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions.

A large number of clinically used drugs and experimental pharmaceuticals possess the N,N-dimethyltryptamine (DMT) structural core. Previous reports have described the reaction of this motif with dichloromethane (DCM), a common laboratory solvent used during extraction and purification, leading to the formation of an undesired quaternary ammonium salt byproduct. However, the kinetics of this reaction under various conditions have not been thoroughly described. Here, we report a series of experiments designed to simulate the exposure of DMT to DCM that would take place during extraction from plant material, biphasic aqueous work-up, or column chromatography purification. We find that the quaternary ammonium salt byproduct forms at an exceedingly slow rate, only accumulates to a significant extent upon prolonged exposure of DMT to DCM, and is readily extracted into water. Our results suggest that DMT can be exposed to DCM under conditions where contact times are limited (<30 min) with minimal risk of degradation and that this byproduct is not observed following aqueous extraction. However, alternative solvents should be considered when the experimental conditions require longer contact times. Our work has important implications for preparing a wide-range of pharmaceuticals bearing the DMT structural motif in high yields and purities

DMT Optimality of LR-Aided Linear Decoders for a General Class of Channels, Lattice Designs, and System Models

The work identifies the first general, explicit, and non-random MIMO encoder-decoder structures that guarantee optimality with respect to the diversity-multiplexing tradeoff (DMT), without employing a computationally expensive maximum-likelihood (ML) receiver. Specifically, the work establishes the DMT optimality of a class of regularized lattice decoders, and more importantly the DMT optimality of their lattice-reduction (LR)-aided linear counterparts. The results hold for all channel statistics, for all channel dimensions, and most interestingly, irrespective of the particular lattice-code applied. As a special case, it is established that the LLL-based LR-aided linear implementation of the MMSE-GDFE lattice decoder facilitates DMT optimal decoding of any lattice code at a worst-case complexity that grows at most linearly in the data rate. This represents a fundamental reduction in the decoding complexity when compared to ML decoding whose complexity is generally exponential in rate. The results' generality lends them applicable to a plethora of pertinent communication scenarios such as quasi-static MIMO, MIMO-OFDM, ISI, cooperative-relaying, and MIMO-ARQ channels, in all of which the DMT optimality of the LR-aided linear decoder is guaranteed. The adopted approach yields insight, and motivates further study, into joint transceiver designs with an improved SNR gap to ML decoding.Comment: 16 pages, 1 figure (3 subfigures), submitted to the IEEE Transactions on Information Theor

Access to and use of clinical services and disease-modifying therapies by people with progressive multiple sclerosis in the United Kingdom

Background: According to current UK guidelines everyone with progressive MS should have access to an MS Specialist but levels of access and use of clinical services is unknown. Our objective was to investigate access to MS Specialists, use of clinical services and disease-modifying therapies (DMTs) by people with progressive MS in the United Kingdom. Methods: A UK wide, online survey was conducted via the UK MS Register. Inclusion criteria: age over 18 years, primary or secondary progressive MS and a member of the UK MS Register. Participants were asked about access to MS Specialists; recent clinical service use; receipt of regular review and current and previous DMT use. Participant demographics; quality of life and disease impact measures were supplied from the UK MS Register. Results: In total 1298 participants responded: 5% were currently taking DMT; 23% had previously taken DMT; and 95% reported access to an MS Specialist. Most utilised services were: MS Doctor/Nurse (50%), General Practitioner (45%), and Physiotherapist (40%). Seventy-four percent received a regular review although 37% received theirs less than annually. Current DMT use was associated with better quality of life but past DMT use was associated with poorer quality of life and higher impact of disease. Conclusions: Access to, and use of, MS Specialists was high. However a gap in service provision was highlighted in both receiving and frequency of regular reviews