Optimal treatment allocations in space and time for on-line control of an emerging infectious disease

A key component in controlling the spread of an epidemic is deciding where, whenand to whom to apply an intervention.We develop a framework for using data to informthese decisionsin realtime.We formalize a treatment allocation strategy as a sequence of functions, oneper treatment period, that map up-to-date information on the spread of an infectious diseaseto a subset of locations where treatment should be allocated. An optimal allocation strategyoptimizes some cumulative outcome, e.g. the number of uninfected locations, the geographicfootprint of the disease or the cost of the epidemic. Estimation of an optimal allocation strategyfor an emerging infectious disease is challenging because spatial proximity induces interferencebetween locations, the number of possible allocations is exponential in the number oflocations, and because disease dynamics and intervention effectiveness are unknown at outbreak.We derive a Bayesian on-line estimator of the optimal allocation strategy that combinessimulation–optimization with Thompson sampling.The estimator proposed performs favourablyin simulation experiments. This work is motivated by and illustrated using data on the spread ofwhite nose syndrome, which is a highly fatal infectious disease devastating bat populations inNorth America

The 1990 progress report and future plans

This document describes the progress and plans of the Artificial Intelligence Research Branch (RIA) at ARC in 1990. Activities span a range from basic scientific research to engineering development and to fielded NASA applications, particularly those applications that are enabled by basic research carried out at RIA. Work is conducted in-house and through collaborative partners in academia and industry. Our major focus is on a limited number of research themes with a dual commitment to technical excellence and proven applicability to NASA short, medium, and long-term problems. RIA acts as the Agency's lead organization for research aspects of artificial intelligence, working closely with a second research laboratory at JPL and AI applications groups at all NASA centers

Quantum Processors and Controllers

In this paper is presented an abstract theory of quantum processors and controllers, special kind of quantum computational network defined on a composite quantum system with two parts: the controlling and controlled subsystems. Such approach formally differs from consideration of quantum control as some external influence on a system using some set of Hamiltonians or quantum gates. The model of programmed quantum controllers discussed in present paper is based on theory of universal deterministic quantum processors (programmable gate arrays). Such quantum devices may simulate arbitrary evolution of quantum system and so demonstrate an example of universal quantum control. Keywords: Quantum, Computer, Control, Processor, UniversalComment: LaTeXe, 7 pp, 2 col, v3: revised and extended (+50%), PhysCon0

Learning the Structure and Parameters of Large-Population Graphical Games from Behavioral Data

We consider learning, from strictly behavioral data, the structure and parameters of linear influence games (LIGs), a class of parametric graphical games introduced by Irfan and Ortiz (2014). LIGs facilitate causal strategic inference (CSI): Making inferences from causal interventions on stable behavior in strategic settings. Applications include the identification of the most influential individuals in large (social) networks. Such tasks can also support policy-making analysis. Motivated by the computational work on LIGs, we cast the learning problem as maximum-likelihood estimation (MLE) of a generative model defined by pure-strategy Nash equilibria (PSNE). Our simple formulation uncovers the fundamental interplay between goodness-of-fit and model complexity: good models capture equilibrium behavior within the data while controlling the true number of equilibria, including those unobserved. We provide a generalization bound establishing the sample complexity for MLE in our framework. We propose several algorithms including convex loss minimization (CLM) and sigmoidal approximations. We prove that the number of exact PSNE in LIGs is small, with high probability; thus, CLM is sound. We illustrate our approach on synthetic data and real-world U.S. congressional voting records. We briefly discuss our learning framework's generality and potential applicability to general graphical games.Comment: Journal of Machine Learning Research. (accepted, pending publication.) Last conference version: submitted March 30, 2012 to UAI 2012. First conference version: entitled, Learning Influence Games, initially submitted on June 1, 2010 to NIPS 201

The Measure and Mismeasure of Fairness: A Critical Review of Fair Machine Learning

The nascent field of fair machine learning aims to ensure that decisions guided by algorithms are equitable. Over the last several years, three formal definitions of fairness have gained prominence: (1) anti-classification, meaning that protected attributes---like race, gender, and their proxies---are not explicitly used to make decisions; (2) classification parity, meaning that common measures of predictive performance (e.g., false positive and false negative rates) are equal across groups defined by the protected attributes; and (3) calibration, meaning that conditional on risk estimates, outcomes are independent of protected attributes. Here we show that all three of these fairness definitions suffer from significant statistical limitations. Requiring anti-classification or classification parity can, perversely, harm the very groups they were designed to protect; and calibration, though generally desirable, provides little guarantee that decisions are equitable. In contrast to these formal fairness criteria, we argue that it is often preferable to treat similarly risky people similarly, based on the most statistically accurate estimates of risk that one can produce. Such a strategy, while not universally applicable, often aligns well with policy objectives; notably, this strategy will typically violate both anti-classification and classification parity. In practice, it requires significant effort to construct suitable risk estimates. One must carefully define and measure the targets of prediction to avoid retrenching biases in the data. But, importantly, one cannot generally address these difficulties by requiring that algorithms satisfy popular mathematical formalizations of fairness. By highlighting these challenges in the foundation of fair machine learning, we hope to help researchers and practitioners productively advance the area