Animal interface: the generosity of domestication

The chapter engages with historical processes and contemporary conditions of animal domestication, arguing that domestication might best be seen as at least as much an emotive or affective process as an instrumental one. It draws on the notion of `corporeal generosity’ to suggest that there are ongoing, generative and unpredictable flows between human and animal bodies that live in close proximity, and that animal domestication has resulted in unforeseen transformations in the bodies of both human and animal participants. It is also argued that pathogen exchange between different species is one of the most important unforeseen outcomes of domestication- and should be viewed both as a destructive and a generative process

Pass it on: towards a political economy of propensity

The paper argues that the work of Gabriel Tarde on imitation provides a fertile means of understanding how capitalism is forging a new affective technology which conforms to a logic of propensity rather than to means-end reasoning. This it does by drawing together a biological understanding of semiconscious cognition with various practical geometric arts so as to re-stage the world as a series of susceptible situations which can be ridden rather than rigidly controlled. The paper examines the advent of technologies which attend to the variable geometry of so-called animal spirits in the realm of business and then, using Tarde's work as a springboard, considers some alternative means of understanding imitative rays which have less instrumental undertones. The paper is an illustration of the way in which biology and culture have increasingly become intertwined

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

Assemblies of huntingtin (HTT) fragments with expanded polyglutamine (polyQ) tracts are a pathological hallmark of Huntington's disease (HD). The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood. Here, we utilized available gene expression data sets of selected brain regions of HD patients and controls for systematic interaction network filtering in order to predict disease-relevant, brain region-specific HTT interaction partners. Starting from a large protein-protein interaction (PPI) data set, a step-by-step computational filtering strategy facilitated the generation of a focused PPI network that directly or indirectly connects 13 proteins potentially dysregulated in HD with the disease protein HTT. This network enabled the discovery of the neuron-specific protein CRMP1 that targets aggregation-prone, N-terminal HTT fragments and suppresses their spontaneous self-assembly into proteotoxic structures in various models of HD. Experimental validation indicates that our network filtering procedure provides a simple but powerful strategy to identify disease-relevant proteins that influence misfolding and aggregation of polyQ disease proteins.DFG [SFB740, 740/2-11, SFB618, 618/3-09, SFB/TRR43 A7]; BMBF(NGFN-Plus) [01GS08169-73, 01GS08150, 01GS08108]; HDSA Coalition for the Cure; EU (EuroSpin) [Health-F2-2009-241498, HEALTH-F2-2009-242167]; Helmholtz Association (MSBN, HelMA) [HA-215]; FCT [IF/00881/2013]info:eu-repo/semantics/publishedVersio

Revision of Specification Automata under Quantitative Preferences

We study the problem of revising specifications with preferences for automata based control synthesis problems. In this class of revision problems, the user provides a numerical ranking of the desirability of the subgoals in their specifications. When the specification cannot be satisfied on the system, then our algorithms automatically revise the specification so that the least desirable user goals are removed from the specification. We propose two different versions of the revision problem with preferences. In the first version, the algorithm returns an exact solution while in the second version the algorithm is an approximation algorithm with non-constant approximation ratio. Finally, we demonstrate the scalability of our algorithms and we experimentally study the approximation ratio of the approximation algorithm on random problem instances.Comment: 9 pages, 3 figures, 3 tables, in Proceedings of the IEEE Conference on Robotics and Automation, May 201

Neurofly 2008 abstracts : the 12th European Drosophila neurobiology conference 6-10 September 2008 Wuerzburg, Germany

This volume consists of a collection of conference abstracts

Signifying the Nation: Gabriel Dumont, Harry Robinson, and the Canadian Captivity Narrative

Gabriel Dumont's Gabriel Dumont Speaks and Harry Robinson's "Captive in an English Circus" are two very different Native-authored texts that counter the dominant narrative of nineteenth-century Canadian nationhood by offering alternative perspectives on the Northwest Rebellions. Locating these texts within the conventions of captivity narratives raises questions about the social significance of the genre by invoking both the politics of form and the form of politics. The two works critically distance the reader from the containment strategies of the captivity genre and reveal its complicity with the imperial expansionist project