7 research outputs found

    Survival of encapsulated islets:More than a membrane story

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    At present, proven clinical treatments but no cures are available for diabetes, a global epidemic with a huge economic burden. Transplantation of islets of Langerhans by their infusion into vascularized organs is an experimental clinical protocol, the first approach to attain cure. However, it is associated with lifelong use of immunosuppressants. To overcome the need for immunosuppression, islets are encapsulated and separated from the host immune system by a permselective membrane. The lead material for this application is alginate which was tested in many animal models and a few clinical trials. This review discusses all aspects related to the function of transplanted encapsulated islets such as the basic requirements from a permselective membrane (e.g., allowable hydrodynamic radii, implications of the thickness of the membrane and relative electrical charge). Another aspect involves adequate oxygen supply, which is essential for survival/performance of transplanted islets, especially when using large retrievable macro-capsules implanted in poorly oxygenated sites like the subcutis. Notably, islets can survive under low oxygen tension and are physiologically active at > 40 Torr. Surprisingly, when densely crowded, islets are fully functional under hyperoxic pressure of up to 500 Torr (> 300% of atmospheric oxygen tension). The review also addresses an additional category of requirements for optimal performance of transplanted islets, named auxiliary technologies. These include control of inflammation, apoptosis, angiogenesis, and the intra-capsular environment. The review highlights that curing diabetes with a functional bio-artificial pancreas requires optimizing all of these aspects, and that significant advances have already been made in many of them

    Technological and Institutional Innovations for Marginalized Smallholders in Agricultural Development

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    Agriculture; Agricultural Economics; Geography, general; Innovation/Technology Managemen

    BEHAVIOUR AND PARTICIPATION OF COMMUNITY ORGANIZATIONS AS LOCAL ACTORS IN POLICY IMPLEMENTATION IN DENPASAR

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    This research is entitled “Behaviour and Participation of Local Community Organizations as Local Actors in Policy Implementation in Denpasar” Denpasar city as one of a Metropolis City is a dense city with a high heterogeneity with all of its development policy problems. A development that can fulfill the citizen needs is a demand that can not be postponed again in this area of regional autonomy. However, in practice, this often encountered many obstacles and problems. Ideally, regional development should involve community participation and based on the neds of citizen itself. Observation methods used by the autor is qualitative descriptive method. The data source obtained from aspect of place, person, and paper. Data collection techniques include observation, interviews, and documentation. The role and participation of community organizations in the city of Denpasar in policy implementation in the city of Denpasar is required by the government to create a synergy of development in the city of Denpasar. Each actor reveals that there is still a lot of the problems that exist in the city of Denpasar, its because Denpasar itself which is now evolving into a dense city with large numbers of immigrants, with all of that problems it really needs synergy between the parties in order to solve it. Based on this observation, as a form of the problematic solution that there are methods of public organizations participation is one that is expected to be implemented. The most expected to be implemented. The most expected participation of actors involved in a variety of policy implementation in the city of Denpasar is the public organization

    DIGITAL LOCAL GOVERNMENT

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    Digital system with its programssuch website, SMS center, e- paper, one stop permit service, electronic identity card,e-planning, e-budgeting, e-procurement, ewarehouse can enhance regional budget managementsystem, legal assurance and order to rules of lawfor local government apparatuses in perfomingtheir duties, with the digital system, effectiveness and efficiency in works can be enhanced too. Digital system that gives transparence space at last can enhance responses of the apparatuse, the society as the sovereignty holder are also given the same space equality in gaining services from the local government apparatuses
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