14 research outputs found
Context-aware stacked convolutional neural networks for classification of breast carcinomas in whole-slide histopathology images
Automated classification of histopathological whole-slide images (WSI) of
breast tissue requires analysis at very high resolutions with a large
contextual area. In this paper, we present context-aware stacked convolutional
neural networks (CNN) for classification of breast WSIs into normal/benign,
ductal carcinoma in situ (DCIS), and invasive ductal carcinoma (IDC). We first
train a CNN using high pixel resolution patches to capture cellular level
information. The feature responses generated by this model are then fed as
input to a second CNN, stacked on top of the first. Training of this stacked
architecture with large input patches enables learning of fine-grained
(cellular) details and global interdependence of tissue structures. Our system
is trained and evaluated on a dataset containing 221 WSIs of H&E stained breast
tissue specimens. The system achieves an AUC of 0.962 for the binary
classification of non-malignant and malignant slides and obtains a three class
accuracy of 81.3% for classification of WSIs into normal/benign, DCIS, and IDC,
demonstrating its potentials for routine diagnostics
Towards Deep Cellular Phenotyping in Placental Histology
The placenta is a complex organ, playing multiple roles during fetal
development. Very little is known about the association between placental
morphological abnormalities and fetal physiology. In this work, we present an
open sourced, computationally tractable deep learning pipeline to analyse
placenta histology at the level of the cell. By utilising two deep
Convolutional Neural Network architectures and transfer learning, we can
robustly localise and classify placental cells within five classes with an
accuracy of 89%. Furthermore, we learn deep embeddings encoding phenotypic
knowledge that is capable of both stratifying five distinct cell populations
and learn intraclass phenotypic variance. We envisage that the automation of
this pipeline to population scale studies of placenta histology has the
potential to improve our understanding of basic cellular placental biology and
its variations, particularly its role in predicting adverse birth outcomes.Comment: Updated MRC funding material. Corrected typo that suggested
ensembling and Inception accuracy were the same (updated to reflect the fact
the ensemble model is 1% better than previously reported
A Review of the Management of Eye Diseases Using Artificial Intelligence, Machine Learning, and Deep Learning in Conjunction with Recent Research on Eye Health Problems: Eye Microbiome
In the field of computer science, Artificial Intelligence can be considered one of the branches that study the development of algorithms that mimic certain aspects of human intelligence. Over the past few years, there has been a rapid advancement in the technology of computer-aided diagnosis (CAD). This in turn has led to an increase in the use of deep learning methods in a variety of applications. For us to be able to understand how AI can be used in order to recognize eye diseases, it is crucial that we have a deep understanding of how AI works in its core concepts. This paper aims to describe the most recent and applicable uses of artificial intelligence in the various fields of ophthalmology disease
RECENT CNN-BASED TECHNIQUES FOR BREAST CANCER HISTOLOGY IMAGE CLASSIFICATION
Histology images are extensively used by pathologists to assess abnormalities and detect malignancy in breast tissues. On the other hand, Convolutional Neural Networks (CNN) are by far, the privileged models for image classification and interpretation. Based on these two facts, we surveyed the recent CNN-based methods for breast cancer histology image analysis. The survey focuses on two major issues usually faced by CNN-based methods namely the design of an appropriate CNN architecture and the lack of a sufficient labelled dataset for training the model. Regarding the design of the CNN architecture, methods examining breast histology images adopt three main approaches: Designing manually from scratch the CNN architecture, using pre-trained models and adopting an automatic architecture design. Methods addressing the lack of labelled datasets are grouped into four categories: methods using pre-trained models, methods using data augmentation, methods adopting weakly supervised learning and those adopting feedforward filter learning. Research works from each category and reported performance are presented in this paper. We conclude the paper by indicating some future research directions related to the analysis of histology images