Abstraction of Elementary Hybrid Systems by Variable Transformation

Elementary hybrid systems (EHSs) are those hybrid systems (HSs) containing elementary functions such as exp, ln, sin, cos, etc. EHSs are very common in practice, especially in safety-critical domains. Due to the non-polynomial expressions which lead to undecidable arithmetic, verification of EHSs is very hard. Existing approaches based on partition of state space or over-approximation of reachable sets suffer from state explosion or inflation of numerical errors. In this paper, we propose a symbolic abstraction approach that reduces EHSs to polynomial hybrid systems (PHSs), by replacing all non-polynomial terms with newly introduced variables. Thus the verification of EHSs is reduced to the one of PHSs, enabling us to apply all the well-established verification techniques and tools for PHSs to EHSs. In this way, it is possible to avoid the limitations of many existing methods. We illustrate the abstraction approach and its application in safety verification of EHSs by several real world examples

Cyber-Virtual Systems: Simulation, Validation & Visualization

We describe our ongoing work and view on simulation, validation and visualization of cyber-physical systems in industrial automation during development, operation and maintenance. System models may represent an existing physical part - for example an existing robot installation - and a software simulated part - for example a possible future extension. We call such systems cyber-virtual systems. In this paper, we present the existing VITELab infrastructure for visualization tasks in industrial automation. The new methodology for simulation and validation motivated in this paper integrates this infrastructure. We are targeting scenarios, where industrial sites which may be in remote locations are modeled and visualized from different sites anywhere in the world. Complementing the visualization work, here, we are also concentrating on software modeling challenges related to cyber-virtual systems and simulation, testing, validation and verification techniques for them. Software models of industrial sites require behavioural models of the components of the industrial sites such as models for tools, robots, workpieces and other machinery as well as communication and sensor facilities. Furthermore, collaboration between sites is an important goal of our work.Comment: Preprint, 9th International Conference on Evaluation of Novel Approaches to Software Engineering (ENASE 2014

Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors.

Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability. Their chemical structure allows the insertion of reporter molecules and surface-binding agents in specific locations, which have been recently exploited for the development of aptamer-based biosensors and direct detection strategies. Mainstream use of these devices, however, still requires significant improvements in optimization for consistency and reproducibility. DNA aptamers are more stable than their RNA counterparts for biomedical applications but have the disadvantage of lacking the wide array of computational tools for RNA structural prediction. Here, we present the first approach to predict from sequence the three-dimensional structures of single stranded (ss) DNA required for aptamer applications, focusing explicitly on ssDNA hairpins. The approach consists of a pipeline that integrates sequentially building ssDNA secondary structure from sequence, constructing equivalent 3D ssRNA models, transforming the 3D ssRNA models into ssDNA 3D structures, and refining the resulting ssDNA 3D structures. Through this pipeline, our approach faithfully predicts the representative structures available in the Nucleic Acid Database and Protein Data Bank databases. Our results, thus, open up a much-needed avenue for integrating DNA in the computational analysis and design of aptamer-based biosensors

Standardized toolchain and model development for video quality assessment: the mission of the joint effort group in VQEG

International audienceSince 1997, the Video Quality Experts Group (VQEG) has been active in the field of subjective and objective video quality assessment. The group has validated competitive quality metrics throughout several projects. Each of these projects requires mandatory actions such as creating a testplan and obtaining databases consisting of degraded video sequences with corresponding subjective quality ratings. Recently, VQEG started a new open initiative, the Joint Effort Group (JEG), for encouraging joint collaboration on all mandatory actions needed to validate video quality metrics. Within the JEG, effort is made to advance the field of both subjective and objective video quality measurement by providing proper software tools and subjective databases to the community. One of the subprojects of the JEG is the joint development of a hybrid H.264/AVC objective quality metric. In this paper, we introduce the JEG and provide an overview of the different ongoing activities within this newly started group

Decision trees in epidemiological research

Background: In many studies, it is of interest to identify population subgroups that are relatively homogeneous with respect to an outcome. The nature of these subgroups can provide insight into effect mechanisms and suggest targets for tailored interventions. However, identifying relevant subgroups can be challenging with standard statistical methods. Main text: We review the literature on decision trees, a family of techniques for partitioning the population, on the basis of covariates, into distinct subgroups who share similar values of an outcome variable. We compare two decision tree methods, the popular Classification and Regression tree (CART) technique and the newer Conditional Inference tree (CTree) technique, assessing their performance in a simulation study and using data from the Box Lunch Study, a randomized controlled trial of a portion size intervention. Both CART and CTree identify homogeneous population subgroups and offer improved prediction accuracy relative to regression-based approaches when subgroups are truly present in the data. An important distinction between CART and CTree is that the latter uses a formal statistical hypothesis testing framework in building decision trees, which simplifies the process of identifying and interpreting the final tree model. We also introduce a novel way to visualize the subgroups defined by decision trees. Our novel graphical visualization provides a more scientifically meaningful characterization of the subgroups identified by decision trees. Conclusions: Decision trees are a useful tool for identifying homogeneous subgroups defined by combinations of individual characteristics. While all decision tree techniques generate subgroups, we advocate the use of the newer CTree technique due to its simplicity and ease of interpretation

Hybrid performance modelling of opportunistic networks

We demonstrate the modelling of opportunistic networks using the process algebra stochastic HYPE. Network traffic is modelled as continuous flows, contact between nodes in the network is modelled stochastically, and instantaneous decisions are modelled as discrete events. Our model describes a network of stationary video sensors with a mobile ferry which collects data from the sensors and delivers it to the base station. We consider different mobility models and different buffer sizes for the ferries. This case study illustrates the flexibility and expressive power of stochastic HYPE. We also discuss the software that enables us to describe stochastic HYPE models and simulate them.Comment: In Proceedings QAPL 2012, arXiv:1207.055

Approximately bisimilar symbolic models for nonlinear control systems

Control systems are usually modeled by differential equations describing how physical phenomena can be influenced by certain control parameters or inputs. Although these models are very powerful when dealing with physical phenomena, they are less suitable to describe software and hardware interfacing the physical world. For this reason there is a growing interest in describing control systems through symbolic models that are abstract descriptions of the continuous dynamics, where each "symbol" corresponds to an "aggregate" of states in the continuous model. Since these symbolic models are of the same nature of the models used in computer science to describe software and hardware, they provide a unified language to study problems of control in which software and hardware interact with the physical world. Furthermore the use of symbolic models enables one to leverage techniques from supervisory control and algorithms from game theory for controller synthesis purposes. In this paper we show that every incrementally globally asymptotically stable nonlinear control system is approximately equivalent (bisimilar) to a symbolic model. The approximation error is a design parameter in the construction of the symbolic model and can be rendered as small as desired. Furthermore if the state space of the control system is bounded the obtained symbolic model is finite. For digital control systems, and under the stronger assumption of incremental input-to-state stability, symbolic models can be constructed through a suitable quantization of the inputs.Comment: Corrected typo