Learning Unions of ω(1)\omega(1)-Dimensional Rectangles

We consider the problem of learning unions of rectangles over the domain $[b]^n$, in the uniform distribution membership query learning setting, where both b and n are "large". We obtain poly$(n, \log b)$-time algorithms for the following classes: - poly$(n \log b)$-way Majority of $O(\frac{\log(n \log b)} {\log \log(n \log b)})$-dimensional rectangles. - Union of poly$(\log(n \log b))$ many $O(\frac{\log^2 (n \log b)} {(\log \log(n \log b) \log \log \log (n \log b))^2})$-dimensional rectangles. - poly$(n \log b)$-way Majority of poly$(n \log b)$-Or of disjoint $O(\frac{\log(n \log b)} {\log \log(n \log b)})$-dimensional rectangles. Our main algorithmic tool is an extension of Jackson's boosting- and Fourier-based Harmonic Sieve algorithm [Jackson 1997] to the domain $[b]^n$, building on work of [Akavia, Goldwasser, Safra 2003]. Other ingredients used to obtain the results stated above are techniques from exact learning [Beimel, Kushilevitz 1998] and ideas from recent work on learning augmented $AC^{0}$ circuits [Jackson, Klivans, Servedio 2002] and on representing Boolean functions as thresholds of parities [Klivans, Servedio 2001].Comment: 25 pages. Some corrections. Recipient of E. M. Gold award ALT 2006. To appear in Journal of Theoretical Computer Scienc

Algorithmic Polynomials

The approximate degree of a Boolean function $f(x_{1},x_{2},\ldots,x_{n})$ is the minimum degree of a real polynomial that approximates $f$ pointwise within $1/3$. Upper bounds on approximate degree have a variety of applications in learning theory, differential privacy, and algorithm design in general. Nearly all known upper bounds on approximate degree arise in an existential manner from bounds on quantum query complexity. We develop a first-principles, classical approach to the polynomial approximation of Boolean functions. We use it to give the first constructive upper bounds on the approximate degree of several fundamental problems: - $O\bigl(n^{\frac{3}{4}-\frac{1}{4(2^{k}-1)}}\bigr)$ for the $k$-element distinctness problem; - $O(n^{1-\frac{1}{k+1}})$ for the $k$-subset sum problem; - $O(n^{1-\frac{1}{k+1}})$ for any $k$-DNF or $k$-CNF formula; - $O(n^{3/4})$ for the surjectivity problem. In all cases, we obtain explicit, closed-form approximating polynomials that are unrelated to the quantum arguments from previous work. Our first three results match the bounds from quantum query complexity. Our fourth result improves polynomially on the $\Theta(n)$ quantum query complexity of the problem and refutes the conjecture by several experts that surjectivity has approximate degree $\Omega(n)$. In particular, we exhibit the first natural problem with a polynomial gap between approximate degree and quantum query complexity

Near-Optimal Lower Bounds on the Threshold Degree and Sign-Rank of AC^0

The threshold degree of a Boolean function $f\colon\{0,1\}^n\to\{0,1\}$ is the minimum degree of a real polynomial $p$ that represents $f$ in sign: $\mathrm{sgn}\; p(x)=(-1)^{f(x)}.$ A related notion is sign-rank, defined for a Boolean matrix $F=[F_{ij}]$ as the minimum rank of a real matrix $M$ with $\mathrm{sgn}\; M_{ij}=(-1)^{F_{ij}}$. Determining the maximum threshold degree and sign-rank achievable by constant-depth circuits ($\text{AC}^{0}$) is a well-known and extensively studied open problem, with complexity-theoretic and algorithmic applications. We give an essentially optimal solution to this problem. For any $\epsilon>0,$ we construct an $\text{AC}^{0}$ circuit in $n$ variables that has threshold degree $\Omega(n^{1-\epsilon})$ and sign-rank $\exp(\Omega(n^{1-\epsilon})),$ improving on the previous best lower bounds of $\Omega(\sqrt{n})$ and $\exp(\tilde{\Omega}(\sqrt{n}))$, respectively. Our results subsume all previous lower bounds on the threshold degree and sign-rank of $\text{AC}^{0}$ circuits of any given depth, with a strict improvement starting at depth $4$. As a corollary, we also obtain near-optimal bounds on the discrepancy, threshold weight, and threshold density of $\text{AC}^{0}$, strictly subsuming previous work on these quantities. Our work gives some of the strongest lower bounds to date on the communication complexity of $\text{AC}^{0}$.Comment: 99 page

Pattern recognition in the nucleation kinetics of non-equilibrium self-assembly

Inspired by biology’s most sophisticated computer, the brain, neural networks constitute a profound reformulation of computational principles. Analogous high-dimensional, highly interconnected computational architectures also arise within information-processing molecular systems inside living cells, such as signal transduction cascades and genetic regulatory networks. Might collective modes analogous to neural computation be found more broadly in other physical and chemical processes, even those that ostensibly play non-information-processing roles? Here we examine nucleation during self-assembly of multicomponent structures, showing that high-dimensional patterns of concentrations can be discriminated and classified in a manner similar to neural network computation. Specifically, we design a set of 917 DNA tiles that can self-assemble in three alternative ways such that competitive nucleation depends sensitively on the extent of colocalization of high-concentration tiles within the three structures. The system was trained in silico to classify a set of 18 grayscale 30 × 30 pixel images into three categories. Experimentally, fluorescence and atomic force microscopy measurements during and after a 150 hour anneal established that all trained images were correctly classified, whereas a test set of image variations probed the robustness of the results. Although slow compared to previous biochemical neural networks, our approach is compact, robust and scalable. Our findings suggest that ubiquitous physical phenomena, such as nucleation, may hold powerful information-processing capabilities when they occur within high-dimensional multicomponent systems