Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia

Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials

Aerospace Medicine and Biology: A continuing bibliography with indexes, supplement 192

This bibliography lists 247 reports, articles, and other documents introduced into the NASA scientific and technical information system in March 1979

Integrated use of LANDSAT data for state resource management

There are no author-identified significant results in this report

Aerospace Medicine and Biology: A continuing bibliography with indexes, supplement 199

This bibliography lists 82 reports, articles, and other documents introduced into the NASA scientific and technical information system in October 1979

Aerospace medicine and biology: A continuing bibliography with indexes, supplement 204

This bibliography lists 140 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1980

Orbital operation for large automated satellites

Orbital operations concepts for the shuttle launched Large Automated Satellites (LAS) are discussed. It includes the orbital operations elements and the major options for accomplishing each element. This study is based on the preliminary payload information available in Level I and II documents and on orbital operations methods used on past programs, both manned and unmanned. It includes a definition of detailed trade studies which need to be performed as satellite design details and organization responsibilities are defined. The major objectives of this study were to define operational methods and requirements for the long duration LAS missions which are effective and primarily economical to implement

A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing

Aerospace medicine and biology: A continuing bibliography with indexes (supplement 324)

This bibliography lists 200 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during May, 1989. Subject coverage includes: aerospace medicine and psychology, life support systems and controlled environments, safety equipment, exobiology and extraterrestrial life, and flight crew behavior and performance

Feasibility study of an Integrated Program for Aerospace-vehicle Design (IPAD) system. Volume 2: Characterization of the IPAD system, phase 1, task 1

The aircraft design process is discussed along with the degree of participation of the various engineering disciplines considered in this feasibility study

Program of Research in Aeronautics

A prospectus of the educational and research opportunities available at the Joint Institute for Advancement of Flight Sciences, operated at NASA Langley Research Center in conjunction with George Washington University's School of Engineering and Applied Sciences is presented. Requirements of admission to various degree programs are given as well as the course offerings in the areas of acoustics, aeronautics, environmental modelling, materials science, and structures and dynamics. Research facilities for each field of study are described. Presentations and publications (including dissertations and theses) generated by each program are listed as well as faculty members visting scientists and engineers