12,791 research outputs found
Data-driven modelling of biological multi-scale processes
Biological processes involve a variety of spatial and temporal scales. A
holistic understanding of many biological processes therefore requires
multi-scale models which capture the relevant properties on all these scales.
In this manuscript we review mathematical modelling approaches used to describe
the individual spatial scales and how they are integrated into holistic models.
We discuss the relation between spatial and temporal scales and the implication
of that on multi-scale modelling. Based upon this overview over
state-of-the-art modelling approaches, we formulate key challenges in
mathematical and computational modelling of biological multi-scale and
multi-physics processes. In particular, we considered the availability of
analysis tools for multi-scale models and model-based multi-scale data
integration. We provide a compact review of methods for model-based data
integration and model-based hypothesis testing. Furthermore, novel approaches
and recent trends are discussed, including computation time reduction using
reduced order and surrogate models, which contribute to the solution of
inference problems. We conclude the manuscript by providing a few ideas for the
development of tailored multi-scale inference methods.Comment: This manuscript will appear in the Journal of Coupled Systems and
Multiscale Dynamics (American Scientific Publishers
A multi-resolution, non-parametric, Bayesian framework for identification of spatially-varying model parameters
This paper proposes a hierarchical, multi-resolution framework for the
identification of model parameters and their spatially variability from noisy
measurements of the response or output. Such parameters are frequently
encountered in PDE-based models and correspond to quantities such as density or
pressure fields, elasto-plastic moduli and internal variables in solid
mechanics, conductivity fields in heat diffusion problems, permeability fields
in fluid flow through porous media etc. The proposed model has all the
advantages of traditional Bayesian formulations such as the ability to produce
measures of confidence for the inferences made and providing not only
predictive estimates but also quantitative measures of the predictive
uncertainty. In contrast to existing approaches it utilizes a parsimonious,
non-parametric formulation that favors sparse representations and whose
complexity can be determined from the data. The proposed framework in
non-intrusive and makes use of a sequence of forward solvers operating at
various resolutions. As a result, inexpensive, coarse solvers are used to
identify the most salient features of the unknown field(s) which are
subsequently enriched by invoking solvers operating at finer resolutions. This
leads to significant computational savings particularly in problems involving
computationally demanding forward models but also improvements in accuracy. It
is based on a novel, adaptive scheme based on Sequential Monte Carlo sampling
which is embarrassingly parallelizable and circumvents issues with slow mixing
encountered in Markov Chain Monte Carlo schemes
Non-rigid Reconstruction with a Single Moving RGB-D Camera
We present a novel non-rigid reconstruction method using a moving RGB-D
camera. Current approaches use only non-rigid part of the scene and completely
ignore the rigid background. Non-rigid parts often lack sufficient geometric
and photometric information for tracking large frame-to-frame motion. Our
approach uses camera pose estimated from the rigid background for foreground
tracking. This enables robust foreground tracking in situations where large
frame-to-frame motion occurs. Moreover, we are proposing a multi-scale
deformation graph which improves non-rigid tracking without compromising the
quality of the reconstruction. We are also contributing a synthetic dataset
which is made publically available for evaluating non-rigid reconstruction
methods. The dataset provides frame-by-frame ground truth geometry of the
scene, the camera trajectory, and masks for background foreground. Experimental
results show that our approach is more robust in handling larger frame-to-frame
motions and provides better reconstruction compared to state-of-the-art
approaches.Comment: Accepted in International Conference on Pattern Recognition (ICPR
2018
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