62,205 research outputs found
Computational Inference of Neural Information Flow Networks
Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow have been made using linear computational methods, but neural interactions are known to be nonlinear. Here, we demonstrate that a dynamic Bayesian network (DBN) inference algorithm we originally developed to infer nonlinear transcriptional regulatory networks from gene expression data collected with microarrays is also successful at inferring nonlinear neural information flow networks from electrophysiology data collected with microelectrode arrays. The inferred networks we recover from the songbird auditory pathway are correctly restricted to a subset of known anatomical paths, are consistent with timing of the system, and reveal both the importance of reciprocal feedback in auditory processing and greater information flow to higher-order auditory areas when birds hear natural as opposed to synthetic sounds. A linear method applied to the same data incorrectly produces networks with information flow to non-neural tissue and over paths known not to exist. To our knowledge, this study represents the first biologically validated demonstration of an algorithm to successfully infer neural information flow networks
Automatic differentiation in machine learning: a survey
Derivatives, mostly in the form of gradients and Hessians, are ubiquitous in
machine learning. Automatic differentiation (AD), also called algorithmic
differentiation or simply "autodiff", is a family of techniques similar to but
more general than backpropagation for efficiently and accurately evaluating
derivatives of numeric functions expressed as computer programs. AD is a small
but established field with applications in areas including computational fluid
dynamics, atmospheric sciences, and engineering design optimization. Until very
recently, the fields of machine learning and AD have largely been unaware of
each other and, in some cases, have independently discovered each other's
results. Despite its relevance, general-purpose AD has been missing from the
machine learning toolbox, a situation slowly changing with its ongoing adoption
under the names "dynamic computational graphs" and "differentiable
programming". We survey the intersection of AD and machine learning, cover
applications where AD has direct relevance, and address the main implementation
techniques. By precisely defining the main differentiation techniques and their
interrelationships, we aim to bring clarity to the usage of the terms
"autodiff", "automatic differentiation", and "symbolic differentiation" as
these are encountered more and more in machine learning settings.Comment: 43 pages, 5 figure
Machine Learning for Fluid Mechanics
The field of fluid mechanics is rapidly advancing, driven by unprecedented
volumes of data from field measurements, experiments and large-scale
simulations at multiple spatiotemporal scales. Machine learning offers a wealth
of techniques to extract information from data that could be translated into
knowledge about the underlying fluid mechanics. Moreover, machine learning
algorithms can augment domain knowledge and automate tasks related to flow
control and optimization. This article presents an overview of past history,
current developments, and emerging opportunities of machine learning for fluid
mechanics. It outlines fundamental machine learning methodologies and discusses
their uses for understanding, modeling, optimizing, and controlling fluid
flows. The strengths and limitations of these methods are addressed from the
perspective of scientific inquiry that considers data as an inherent part of
modeling, experimentation, and simulation. Machine learning provides a powerful
information processing framework that can enrich, and possibly even transform,
current lines of fluid mechanics research and industrial applications.Comment: To appear in the Annual Reviews of Fluid Mechanics, 202
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