87,333 research outputs found
Ecosystem-Oriented Distributed Evolutionary Computing
We create a novel optimisation technique inspired by natural ecosystems,
where the optimisation works at two levels: a first optimisation, migration of
genes which are distributed in a peer-to-peer network, operating continuously
in time; this process feeds a second optimisation based on evolutionary
computing that operates locally on single peers and is aimed at finding
solutions to satisfy locally relevant constraints. We consider from the domain
of computer science distributed evolutionary computing, with the relevant
theory from the domain of theoretical biology, including the fields of
evolutionary and ecological theory, the topological structure of ecosystems,
and evolutionary processes within distributed environments. We then define
ecosystem- oriented distributed evolutionary computing, imbibed with the
properties of self-organisation, scalability and sustainability from natural
ecosystems, including a novel form of distributed evolu- tionary computing.
Finally, we conclude with a discussion of the apparent compromises resulting
from the hybrid model created, such as the network topology.Comment: 8 pages, 5 figures. arXiv admin note: text overlap with
arXiv:1112.0204, arXiv:0712.4159, arXiv:0712.4153, arXiv:0712.4102,
arXiv:0910.067
Learning mutational graphs of individual tumour evolution from single-cell and multi-region sequencing data
Background. A large number of algorithms is being developed to reconstruct
evolutionary models of individual tumours from genome sequencing data. Most
methods can analyze multiple samples collected either through bulk multi-region
sequencing experiments or the sequencing of individual cancer cells. However,
rarely the same method can support both data types.
Results. We introduce TRaIT, a computational framework to infer mutational
graphs that model the accumulation of multiple types of somatic alterations
driving tumour evolution. Compared to other tools, TRaIT supports multi-region
and single-cell sequencing data within the same statistical framework, and
delivers expressive models that capture many complex evolutionary phenomena.
TRaIT improves accuracy, robustness to data-specific errors and computational
complexity compared to competing methods.
Conclusions. We show that the application of TRaIT to single-cell and
multi-region cancer datasets can produce accurate and reliable models of
single-tumour evolution, quantify the extent of intra-tumour heterogeneity and
generate new testable experimental hypotheses
Digital Ecosystems: Ecosystem-Oriented Architectures
We view Digital Ecosystems to be the digital counterparts of biological
ecosystems. Here, we are concerned with the creation of these Digital
Ecosystems, exploiting the self-organising properties of biological ecosystems
to evolve high-level software applications. Therefore, we created the Digital
Ecosystem, a novel optimisation technique inspired by biological ecosystems,
where the optimisation works at two levels: a first optimisation, migration of
agents which are distributed in a decentralised peer-to-peer network, operating
continuously in time; this process feeds a second optimisation based on
evolutionary computing that operates locally on single peers and is aimed at
finding solutions to satisfy locally relevant constraints. The Digital
Ecosystem was then measured experimentally through simulations, with measures
originating from theoretical ecology, evaluating its likeness to biological
ecosystems. This included its responsiveness to requests for applications from
the user base, as a measure of the ecological succession (ecosystem maturity).
Overall, we have advanced the understanding of Digital Ecosystems, creating
Ecosystem-Oriented Architectures where the word ecosystem is more than just a
metaphor.Comment: 39 pages, 26 figures, journa
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