48,370 research outputs found
Convex Learning of Multiple Tasks and their Structure
Reducing the amount of human supervision is a key problem in machine learning
and a natural approach is that of exploiting the relations (structure) among
different tasks. This is the idea at the core of multi-task learning. In this
context a fundamental question is how to incorporate the tasks structure in the
learning problem.We tackle this question by studying a general computational
framework that allows to encode a-priori knowledge of the tasks structure in
the form of a convex penalty; in this setting a variety of previously proposed
methods can be recovered as special cases, including linear and non-linear
approaches. Within this framework, we show that tasks and their structure can
be efficiently learned considering a convex optimization problem that can be
approached by means of block coordinate methods such as alternating
minimization and for which we prove convergence to the global minimum.Comment: 26 pages, 1 figure, 2 table
The role of binding site on the mechanical unfolding mechanism of ubiquitin.
We apply novel atomistic simulations based on potential energy surface exploration to investigate the constant force-induced unfolding of ubiquitin. At the experimentally-studied force clamping level of 100 pN, we find a new unfolding mechanism starting with the detachment between β5 and β3 involving the binding site of ubiquitin, the Ile44 residue. This new unfolding pathway leads to the discovery of new intermediate configurations, which correspond to the end-to-end extensions previously seen experimentally. More importantly, it demonstrates the novel finding that the binding site of ubiquitin can be responsible not only for its biological functions, but also its unfolding dynamics. We also report in contrast to previous single molecule constant force experiments that when the clamping force becomes smaller than about 300 pN, the number of intermediate configurations increases dramatically, where almost all unfolding events at 100 pN involve an intermediate configuration. By directly calculating the life times of the intermediate configurations from the height of the barriers that were crossed on the potential energy surface, we demonstrate that these intermediate states were likely not observed experimentally due to their lifetimes typically being about two orders of magnitude smaller than the experimental temporal resolution
Adaptive Penalty and Barrier function based on Fuzzy Logic
Optimization methods have been used in many areas of knowledge, such as Engineering, Statistics, Chemistry, among others, to solve optimization problems. In many cases it is not possible to use derivative methods, due to the characteristics of the problem to be solved and/or its constraints, for example if the involved functions are non-smooth and/or their derivatives are not know. To solve this type of problems a Java based API has been implemented, which includes only derivative-free optimization methods, and that can be used to solve both constrained and unconstrained problems. For solving constrained problems, the classic Penalty and Barrier functions were included in the API. In this paper a new approach to Penalty and Barrier functions, based on Fuzzy Logic, is proposed. Two penalty functions, that impose a progressive penalization to solutions that violate the constraints, are discussed. The implemented functions impose a low penalization when the violation of the constraints is low and a heavy penalty when the violation is high. Numerical results, obtained using twenty-eight test problems, comparing the proposed Fuzzy Logic based functions to six of the classic Penalty and Barrier functions are presented. Considering the achieved results, it can be concluded that the proposed penalty functions besides being very robust also have a very good performance
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