Combining Bayesian Approaches and Evolutionary Techniques for the Inference of Breast Cancer Networks

Gene and protein networks are very important to model complex large-scale systems in molecular biology. Inferring or reverseengineering such networks can be defined as the process of identifying gene/protein interactions from experimental data through computational analysis. However, this task is typically complicated by the enormously large scale of the unknowns in a rather small sample size. Furthermore, when the goal is to study causal relationships within the network, tools capable of overcoming the limitations of correlation networks are required. In this work, we make use of Bayesian Graphical Models to attach this problem and, specifically, we perform a comparative study of different state-of-the-art heuristics, analyzing their performance in inferring the structure of the Bayesian Network from breast cancer data

A Survey of Adaptive Resonance Theory Neural Network Models for Engineering Applications

This survey samples from the ever-growing family of adaptive resonance theory (ART) neural network models used to perform the three primary machine learning modalities, namely, unsupervised, supervised and reinforcement learning. It comprises a representative list from classic to modern ART models, thereby painting a general picture of the architectures developed by researchers over the past 30 years. The learning dynamics of these ART models are briefly described, and their distinctive characteristics such as code representation, long-term memory and corresponding geometric interpretation are discussed. Useful engineering properties of ART (speed, configurability, explainability, parallelization and hardware implementation) are examined along with current challenges. Finally, a compilation of online software libraries is provided. It is expected that this overview will be helpful to new and seasoned ART researchers

A Bayesian Ensemble Regression Framework on the Angry Birds Game

An ensemble inference mechanism is proposed on the Angry Birds domain. It is based on an efficient tree structure for encoding and representing game screenshots, where it exploits its enhanced modeling capability. This has the advantage to establish an informative feature space and modify the task of game playing to a regression analysis problem. To this direction, we assume that each type of object material and bird pair has its own Bayesian linear regression model. In this way, a multi-model regression framework is designed that simultaneously calculates the conditional expectations of several objects and makes a target decision through an ensemble of regression models. Learning procedure is performed according to an online estimation strategy for the model parameters. We provide comparative experimental results on several game levels that empirically illustrate the efficiency of the proposed methodology.Comment: Angry Birds AI Symposium, ECAI 201

Outlier detection techniques for wireless sensor networks: A survey

In the field of wireless sensor networks, those measurements that significantly deviate from the normal pattern of sensed data are considered as outliers. The potential sources of outliers include noise and errors, events, and malicious attacks on the network. Traditional outlier detection techniques are not directly applicable to wireless sensor networks due to the nature of sensor data and specific requirements and limitations of the wireless sensor networks. This survey provides a comprehensive overview of existing outlier detection techniques specifically developed for the wireless sensor networks. Additionally, it presents a technique-based taxonomy and a comparative table to be used as a guideline to select a technique suitable for the application at hand based on characteristics such as data type, outlier type, outlier identity, and outlier degree

Modeling cumulative biological phenomena with Suppes-Bayes Causal Networks

Several diseases related to cell proliferation are characterized by the accumulation of somatic DNA changes, with respect to wildtype conditions. Cancer and HIV are two common examples of such diseases, where the mutational load in the cancerous/viral population increases over time. In these cases, selective pressures are often observed along with competition, cooperation and parasitism among distinct cellular clones. Recently, we presented a mathematical framework to model these phenomena, based on a combination of Bayesian inference and Suppes' theory of probabilistic causation, depicted in graphical structures dubbed Suppes-Bayes Causal Networks (SBCNs). SBCNs are generative probabilistic graphical models that recapitulate the potential ordering of accumulation of such DNA changes during the progression of the disease. Such models can be inferred from data by exploiting likelihood-based model-selection strategies with regularization. In this paper we discuss the theoretical foundations of our approach and we investigate in depth the influence on the model-selection task of: (i) the poset based on Suppes' theory and (ii) different regularization strategies. Furthermore, we provide an example of application of our framework to HIV genetic data highlighting the valuable insights provided by the inferred

Machine Learning Techniques for Stellar Light Curve Classification

We apply machine learning techniques in an attempt to predict and classify stellar properties from noisy and sparse time series data. We preprocessed over 94 GB of Kepler light curves from MAST to classify according to ten distinct physical properties using both representation learning and feature engineering approaches. Studies using machine learning in the field have been primarily done on simulated data, making our study one of the first to use real light curve data for machine learning approaches. We tuned our data using previous work with simulated data as a template and achieved mixed results between the two approaches. Representation learning using a Long Short-Term Memory (LSTM) Recurrent Neural Network (RNN) produced no successful predictions, but our work with feature engineering was successful for both classification and regression. In particular, we were able to achieve values for stellar density, stellar radius, and effective temperature with low error (~ 2 - 4%) and good accuracy (~ 75%) for classifying the number of transits for a given star. The results show promise for improvement for both approaches upon using larger datasets with a larger minority class. This work has the potential to provide a foundation for future tools and techniques to aid in the analysis of astrophysical data.Comment: Accepted to The Astronomical Journa

Large scale probabilistic available bandwidth estimation

The common utilization-based definition of available bandwidth and many of the existing tools to estimate it suffer from several important weaknesses: i) most tools report a point estimate of average available bandwidth over a measurement interval and do not provide a confidence interval; ii) the commonly adopted models used to relate the available bandwidth metric to the measured data are invalid in almost all practical scenarios; iii) existing tools do not scale well and are not suited to the task of multi-path estimation in large-scale networks; iv) almost all tools use ad-hoc techniques to address measurement noise; and v) tools do not provide enough flexibility in terms of accuracy, overhead, latency and reliability to adapt to the requirements of various applications. In this paper we propose a new definition for available bandwidth and a novel framework that addresses these issues. We define probabilistic available bandwidth (PAB) as the largest input rate at which we can send a traffic flow along a path while achieving, with specified probability, an output rate that is almost as large as the input rate. PAB is expressed directly in terms of the measurable output rate and includes adjustable parameters that allow the user to adapt to different application requirements. Our probabilistic framework to estimate network-wide probabilistic available bandwidth is based on packet trains, Bayesian inference, factor graphs and active sampling. We deploy our tool on the PlanetLab network and our results show that we can obtain accurate estimates with a much smaller measurement overhead compared to existing approaches.Comment: Submitted to Computer Network

Social status in a social structure: noisy signaling in networks

How do incentives to engage in costly signaling depend on social structure? This paper formalises and extends Thorstein Veblen’s theory of how costly signaling by conspicuous consumption depends on social structure. A noisy signaling game is introduced in which spectators observe signals only imperfectly, and use Bayesian updating to interpret the observed signals. It is shown that this noisy signaling game has (under some weak regularity conditions) a unique plausible Perfect Bayesian Nash equilibrium. Then, a social information network is introduced as a second source of information about a player’s type. Equilibrium signaling depends in the resulting game on the relative quality of the substitute sources of information, which depends again on the social network. For some highly stylised networks, the dependence of equilibrium costly signaling on network characteristics (network size, density and connectedness, the centrality of the consumer in the network) is studied, and a simple dominance result for more arbitrary networks is suggested.