Data mining in medical records for the enhancement of strategic decisions: a case study

The impact and popularity of competition concept has been increasing in the last decades and this concept has escalated the importance of giving right decision for organizations. Decision makers have encountered the fact of using proper scientific methods instead of using intuitive and emotional choices in decision making process. In this context, many decision support models and relevant systems are still being developed in order to assist the strategic management mechanisms. There is also a critical need for automated approaches for effective and efficient utilization of massive amount of data to support corporate and individuals in strategic planning and decision-making. Data mining techniques have been used to uncover hidden patterns and relations, to summarize the data in novel ways that are both understandable and useful to the executives and also to predict future trends and behaviors in business. There has been a large body of research and practice focusing on different data mining techniques and methodologies. In this study, a large volume of record set extracted from an outpatient clinic’s medical database is used to apply data mining techniques. In the first phase of the study, the raw data in the record set are collected, preprocessed, cleaned up and eventually transformed into a suitable format for data mining. In the second phase, some of the association rule algorithms are applied to the data set in order to uncover rules for quantifying the relationship between some of the attributes in the medical records. The results are observed and comparative analysis of the observed results among different association algorithms is made. The results showed us that some critical and reasonable relations exist in the outpatient clinic operations of the hospital which could aid the hospital management to change and improve their managerial strategies regarding the quality of services given to outpatients.Decision Making, Medical Records, Data Mining, Association Rules, Outpatient Clinic.

Machine Learning and Rule Mining Techniques in the Study of Gene Inactivation and RNA Interference

RNA interference (RNAi) and gene inactivation are extensively used biological terms in biomedical research. Two categories of small ribonucleic acid (RNA) molecules, viz., microRNA (miRNA) and small interfering RNA (siRNA) are central to the RNAi. There are various kinds of algorithms developed related to RNAi and gene silencing. In this book chapter, we provided a comprehensive review of various machine learning and association rule mining algorithms developed to handle different biological problems such as detection of gene signature, biomarker, gene module, potentially disordered protein, differentially methylated region and many more. We also provided a comparative study of different well-known classifiers along with other used methods. In addition, we demonstrated the brief biological information regarding the immense biological challenges for gene activation as well as their advantages, disadvantages and possible therapeutic strategies. Finally, our study helps the bioinformaticians to understand the overall immense idea in different research dimensions including several learning algorithms for the benevolent of the disease discovery

Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology

Since it is impossible to recognize malignancy at fine needle aspiration (FNA) cytology in indeterminate thyroid nodules, surgery is recommended for all of them. However, cancer rate at final histology is < 30%. Many different test-methods have been proposed to increase diagnostic accuracy in such lesions, including Galectin-3-ICC (GAL-3-ICC), BRAF mutation analysis (BRAF), Gene Expression Classifier (GEC) alone and GEC+BRAF, mutation/fusion (M/F) panel, alone, M/F panel+miRNA GEC, and M/F panel by next generation sequencing (NGS), FDG-PET/CT, MIBI-Scan and TSHR mRNA blood assay. We performed systematic reviews and meta-analyses to compare their features, feasibility, diagnostic performance and cost. GEC, GEC+BRAF, M/F panel+miRNA GEC and M/F panel by NGS were the best in ruling-out malignancy (sensitivity = 90%, 89%, 89% and 90% respectively). BRAF and M/F panel alone and by NGS were the best in ruling-in malignancy (specificity = 100%, 93% and 93%). The M/F by NGS showed the highest accuracy (92%) and BRAF the highest diagnostic odds ratio (DOR) (247). GAL-3-ICC performed well as rule-out (sensitivity = 83%) and rule-in test (specificity = 85%), with good accuracy (84%) and high DOR (27) and is one of the cheapest (113 USD) and easiest one to be performed in different clinical settings. In conclusion, the more accurate molecular-based test-methods are still expensive and restricted to few, highly specialized and centralized laboratories. GAL-3-ICC, although limited by some false negatives, represents the most suitable screening test-method to be applied on a large-scale basis in the diagnostic algorithm of indeterminate thyroid lesions

A Hybrid Web Recommendation System based on the Improved Association Rule Mining Algorithm

As the growing interest of web recommendation systems those are applied to deliver customized data for their users, we started working on this system. Generally the recommendation systems are divided into two major categories such as collaborative recommendation system and content based recommendation system. In case of collaborative recommen-dation systems, these try to seek out users who share same tastes that of given user as well as recommends the websites according to the liking given user. Whereas the content based recommendation systems tries to recommend web sites similar to those web sites the user has liked. In the recent research we found that the efficient technique based on asso-ciation rule mining algorithm is proposed in order to solve the problem of web page recommendation. Major problem of the same is that the web pages are given equal importance. Here the importance of pages changes according to the fre-quency of visiting the web page as well as amount of time user spends on that page. Also recommendation of newly added web pages or the pages those are not yet visited by users are not included in the recommendation set. To over-come this problem, we have used the web usage log in the adaptive association rule based web mining where the asso-ciation rules were applied to personalization. This algorithm was purely based on the Apriori data mining algorithm in order to generate the association rules. However this method also suffers from some unavoidable drawbacks. In this paper we are presenting and investigating the new approach based on weighted Association Rule Mining Algorithm and text mining. This is improved algorithm which adds semantic knowledge to the results, has more efficiency and hence gives better quality and performances as compared to existing approaches.Comment: 9 pages, 7 figures, 2 table