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EEG Resting-State Brain Topological Reorganization as a Function of Age
Resting state connectivity has been increasingly studied to investigate the effects of aging on the brain. A reduced organization
in the communication between brain areas was demonstrated b
y combining a variety of different imaging technologies (fMRI,
EEG, and MEG) and graph theory. In this paper, we propose a methodology to get new insights into resting state connectivity and
its variations with age, by combining advanced techniques of effective connectivity estimation, graph theoretical approach, and
classification by SVM method. We analyzed high density EEG signal
srecordedatrestfrom71healthysubjects(age:20–63years).
Weighted and directed connectivity was computed by means of Partial Directed Coherence based on a General Linear Kalman filter
approach. To keep the information collected by the estimator, weighted and directed graph indices were extracted from the resulting
networks. A relation between brain network properties and age of the subject was found, indicating a tendency of the network to
randomly organize increasing with age. This result is also confirmed dividing the whole population into two subgroups according
to the age (young and middle-aged adults): significant differences exist in terms of network organization measures. Classification
of the subjects by means of such indices returns an accuracy greater than 80
An integrative clustering approach combining particle swarm optimization and formal concept analysis
Semi-supervised model-based clustering with controlled clusters leakage
In this paper, we focus on finding clusters in partially categorized data
sets. We propose a semi-supervised version of Gaussian mixture model, called
C3L, which retrieves natural subgroups of given categories. In contrast to
other semi-supervised models, C3L is parametrized by user-defined leakage
level, which controls maximal inconsistency between initial categorization and
resulting clustering. Our method can be implemented as a module in practical
expert systems to detect clusters, which combine expert knowledge with true
distribution of data. Moreover, it can be used for improving the results of
less flexible clustering techniques, such as projection pursuit clustering. The
paper presents extensive theoretical analysis of the model and fast algorithm
for its efficient optimization. Experimental results show that C3L finds high
quality clustering model, which can be applied in discovering meaningful groups
in partially classified data
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