Synthetic biology and microdevices : a powerful combination

Recent developments demonstrate that the combination of microbiology with micro-and nanoelectronics is a successful approach to develop new miniaturized sensing devices and other technologies. In the last decade, there has been a shift from the optimization of the abiotic components, for example, the chip, to the improvement of the processing capabilities of cells through genetic engineering. The synthetic biology approach will not only give rise to systems with new functionalities, but will also improve the robustness and speed of their response towards applied signals. To this end, the development of new genetic circuits has to be guided by computational design methods that enable to tune and optimize the circuit response. As the successful design of genetic circuits is highly dependent on the quality and reliability of its composing elements, intense characterization of standard biological parts will be crucial for an efficient rational design process in the development of new genetic circuits. Microengineered devices can thereby offer a new analytical approach for the study of complex biological parts and systems. By summarizing the recent techniques in creating new synthetic circuits and in integrating biology with microdevices, this review aims at emphasizing the power of combining synthetic biology with microfluidics and microelectronics

A design tool for high-resolution high-frequency cascade continuous- time Σ∆ modulators

Event: Microtechnologies for the New Millennium, 2007, Maspalomas, Gran Canaria, SpainThis paper introduces a CAD methodology to assist the de signer in the implementation of continuous-time (CT) cas- cade Σ∆ modulators. The salient features of this methodology ar e: (a) flexible behavioral modeling for optimum accuracy- efficiency trade-offs at different stages of the top-down synthesis process; (b) direct synthesis in the continuous-time domain for minimum circuit complexity and sensitivity; a nd (c) mixed knowledge-based and optimization-based architec- tural exploration and specification transmission for enhanced circuit performance. The applicability of this methodology will be illustrated via the design of a 12 bit 20 MHz CT Σ∆ modulator in a 1.2V 130nm CMOS technology.Ministerio de Ciencia y Educación TEC2004-01752/MICMinisterio de Industria, Turismo y Comercio FIT-330100-2006-134 SPIRIT Projec

Fully integrated CMOS power amplifier design using the distributed active-transformer architecture

A novel on-chip impedance matching and power-combining method, the distributed active transformer is presented. It combines several low-voltage push-pull amplifiers efficiently with their outputs in series to produce a larger output power while maintaining a 50-Ω match. It also uses virtual ac grounds and magnetic couplings extensively to eliminate the need for any off-chip component, such as tuned bonding wires or external inductors. Furthermore, it desensitizes the operation of the amplifier to the inductance of bonding wires making the design more reproducible. To demonstrate the feasibility of this concept, a 2.4-GHz 2-W 2-V truly fully integrated power amplifier with 50-Ω input and output matching has been fabricated using 0.35-μm CMOS transistors. It achieves a power added efficiency (PAE) of 41 % at this power level. It can also produce 450 mW using a 1-V supply. Harmonic suppression is 64 dBc or better. This new topology makes possible a truly fully integrated watt-level gigahertz range low-voltage CMOS power amplifier for the first time

Global design of analog cells using statistical optimization techniques

We present a methodology for automated sizing of analog cells using statistical optimization in a simulation based approach. This methodology enables us to design complex analog cells from scratch within reasonable CPU time. Three different specification types are covered: strong constraints on the electrical performance of the cells, weak constraints on this performance, and design objectives. A mathematical cost function is proposed and a bunch of heuristics is given to increase accuracy and reduce CPU time to minimize the cost function. A technique is also presented to yield designs with reduced variability in the performance parameters, under random variations of the transistor technological parameters. Several CMOS analog cells with complexity levels up to 48 transistors are designed for illustration. Measurements from fabricated prototypes demonstrate the suitability of the proposed methodology

Voltage Stabilization in Microgrids via Quadratic Droop Control

We consider the problem of voltage stability and reactive power balancing in islanded small-scale electrical networks outfitted with DC/AC inverters ("microgrids"). A droop-like voltage feedback controller is proposed which is quadratic in the local voltage magnitude, allowing for the application of circuit-theoretic analysis techniques to the closed-loop system. The operating points of the closed-loop microgrid are in exact correspondence with the solutions of a reduced power flow equation, and we provide explicit solutions and small-signal stability analyses under several static and dynamic load models. Controller optimality is characterized as follows: we show a one-to-one correspondence between the high-voltage equilibrium of the microgrid under quadratic droop control, and the solution of an optimization problem which minimizes a trade-off between reactive power dissipation and voltage deviations. Power sharing performance of the controller is characterized as a function of the controller gains, network topology, and parameters. Perhaps surprisingly, proportional sharing of the total load between inverters is achieved in the low-gain limit, independent of the circuit topology or reactances. All results hold for arbitrary grid topologies, with arbitrary numbers of inverters and loads. Numerical results confirm the robustness of the controller to unmodeled dynamics.Comment: 14 pages, 8 figure

An optimized tuned mass damper/harvester device

Much work has been conducted on vibration absorbers, such as tuned mass dampers (TMD), where significant energy is extracted from a structure. Traditionally, this energy is dissipated through the devices as heat. In this paper, the concept of recovering some of this energy electrically and reuse it for structural control or health monitoring is investigated. The energy-dissipating damper of a TMD is replaced with an electromagnetic device in order to transform mechanical vibration into electrical energy. That gives the possibility of controlled damping force whilst generating useful electrical energy. Both analytical and experimental results from an adaptive and a semi-active tuned mass damper/harvester are presented. The obtained results suggest that sufficient energy might be harvested for the device to tune itself to optimise vibration suppression

Optimization of net power density in Reverse Electrodialysis

Reverse Electrodialysis (RED) extracts electrical energy from the salinity difference between two solutions using selective ion exchange membranes. In RED, conditions yielding a large net power density (NPD) are generally desired, due to the still large cost of the membranes. NPD depends on a large number of physical and geometric parameters. Some of these, for example the inlet concentrations of concentrate and diluate, can be regarded as “scenario” variables, imposed by external constraints (e.g., availability) or chosen by different criteria than NPD maximization. Others, namely the thicknesses HCONC, HDIL and the velocities UCONC, UDIL in the concentrate and diluate channels, can be regarded as free design parameters and can be chosen so as to maximize NPD. In the present study, a simplified model of a RED stack was coupled with an optimization algorithm in order to determine the conditions of maximum NPD in the space of the variables HCONC, HDIL,UCONC, UDIL for different sets of “scenario” variables. The study shows that an optimal choice of the free design parameters for any given scenario, as opposed to the adoption of standard fixed values for the same parameters, may provide significant improvements in NPD