Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases

Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible, including biomarkers, genomic profiles, cognitive and behavioral phenotypes, high-frequency assessments, and medical imaging. Although these data are incredibly complex, they can potentially be used to understand multi-determinant causal relationships, elucidate modifiable factors, and ultimately customize treatments based on individual parameters. Especially for neurodegenerative diseases, where an effective therapeutic agent has yet to be discovered, there remains a critical need for an interdisciplinary perspective on data and information management due to the number of unanswered questions. Biomedical informatics is a multidisciplinary field that falls at the intersection of information technology, computer and data science, engineering, and healthcare that will be instrumental for uncovering novel insights into neurodegenerative disease research, including both causal relationships and therapeutic targets and maximizing the utility of both clinical and research data. The present study aims to provide a brief overview of biomedical informatics and how clinical data applications such as clinical decision support tools can be developed to derive new knowledge from the wealth of available data to advance clinical care and scientific research of neurodegenerative diseases in the era of precision medicine

Fog-enabled Edge Learning for Cognitive Content-Centric Networking in 5G

By caching content at network edges close to the users, the content-centric networking (CCN) has been considered to enforce efficient content retrieval and distribution in the fifth generation (5G) networks. Due to the volume, velocity, and variety of data generated by various 5G users, an urgent and strategic issue is how to elevate the cognitive ability of the CCN to realize context-awareness, timely response, and traffic offloading for 5G applications. In this article, we envision that the fundamental work of designing a cognitive CCN (C-CCN) for the upcoming 5G is exploiting the fog computing to associatively learn and control the states of edge devices (such as phones, vehicles, and base stations) and in-network resources (computing, networking, and caching). Moreover, we propose a fog-enabled edge learning (FEL) framework for C-CCN in 5G, which can aggregate the idle computing resources of the neighbouring edge devices into virtual fogs to afford the heavy delay-sensitive learning tasks. By leveraging artificial intelligence (AI) to jointly processing sensed environmental data, dealing with the massive content statistics, and enforcing the mobility control at network edges, the FEL makes it possible for mobile users to cognitively share their data over the C-CCN in 5G. To validate the feasibility of proposed framework, we design two FEL-advanced cognitive services for C-CCN in 5G: 1) personalized network acceleration, 2) enhanced mobility management. Simultaneously, we present the simulations to show the FEL's efficiency on serving for the mobile users' delay-sensitive content retrieval and distribution in 5G.Comment: Submitted to IEEE Communications Magzine, under review, Feb. 09, 201

weSPOT: a cloud-based approach for personal and social inquiry

Scientific inquiry is at the core of the curricula of schools and universities across Europe. weSPOT is a new European initiative proposing a cloud-based approach for personal and social inquiry. weSPOT aims at enabling students to create their mashups out of cloud-based tools in order to perform scientific investigations. Students will also be able to share their inquiry accomplishments in social networks and receive feedback from the learning environment and their peers

Designing a gamified social platform for people living with dementia and their live-in family caregivers

In the current paper, a social gamified platform for people living with dementia and their live-in family caregivers, integrating a broader diagnostic approach and interactive interventions is presented. The CAREGIVERSPRO-MMD (C-MMD) platform constitutes a support tool for the patient and the informal caregiver - also referred to as the dyad - that strengthens self-care, and builds community capacity and engagement at the point of care. The platform is implemented to improve social collaboration, adherence to treatment guidelines through gamification, recognition of progress indicators and measures to guide management of patients with dementia, and strategies and tools to improve treatment interventions and medication adherence. Moreover, particular attention was provided on guidelines, considerations and user requirements for the design of a User-Centered Design (UCD) platform. The design of the platform has been based on a deep understanding of users, tasks and contexts in order to improve platform usability, and provide adaptive and intuitive User Interfaces with high accessibility. In this paper, the architecture and services of the C-MMD platform are presented, and specifically the gamification aspects. © 2018 Association for Computing Machinery.Peer ReviewedPostprint (author's final draft

Skills and Knowledge for Data-Intensive Environmental Research.

The scale and magnitude of complex and pressing environmental issues lend urgency to the need for integrative and reproducible analysis and synthesis, facilitated by data-intensive research approaches. However, the recent pace of technological change has been such that appropriate skills to accomplish data-intensive research are lacking among environmental scientists, who more than ever need greater access to training and mentorship in computational skills. Here, we provide a roadmap for raising data competencies of current and next-generation environmental researchers by describing the concepts and skills needed for effectively engaging with the heterogeneous, distributed, and rapidly growing volumes of available data. We articulate five key skills: (1) data management and processing, (2) analysis, (3) software skills for science, (4) visualization, and (5) communication methods for collaboration and dissemination. We provide an overview of the current suite of training initiatives available to environmental scientists and models for closing the skill-transfer gap